公开(公告)号：US20070203473A1

公开(公告)日：2007-08-30

申请号：US11675693

申请日：2007-02-16

申请人： Michael Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

发明人： Michael Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

IPC分类号： A61M25/00

CPC分类号： A61M5/14276 ,  A61M5/14244 ,  A61M5/16813 ,  A61M2205/0266 ,  A61N1/0568

摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

摘要翻译： 一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。 待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。 医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

公开(公告)号：US20060235499A1

公开(公告)日：2006-10-19

申请号：US11105791

申请日：2005-04-14

申请人： Ronald Heil ,  Michael Nelson

发明人： Ronald Heil ,  Michael Nelson

IPC分类号： A61N1/05

CPC分类号： A61N1/0575 ,  A61N1/0568

摘要： In one embodiment, the present invention provides a cardiac lead including a fixation member extending from a distal end of the lead. The fixation member includes a coated portion and an uncoated portion. The coating that forms the coated portion includes a biocompatible polymer material and a therapeutic agent. The coating may provide for the delivery of the therapeutic agent directly at the sight of fixation for an extended period of time.

摘要翻译： 在一个实施例中，本发明提供一种心脏引线，其​​包括从引线的远端延伸的固定构件。 固定构件包括涂覆部分和未涂覆部分。 形成涂布部分的涂层包括生物相容的聚合物材料和治疗剂。 涂层可以提供治疗剂直接在固定的时间内延长的时间段。

公开(公告)号：US20060136025A1

公开(公告)日：2006-06-22

申请号：US11237288

申请日：2005-09-27

申请人： William Webler

发明人： William Webler

IPC分类号： A61N1/05

CPC分类号： A61M25/0084 ,  A61N1/0568

摘要： A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration.

公开(公告)号：US20060039949A1

公开(公告)日：2006-02-23

申请号：US10921793

申请日：2004-08-20

申请人： Jeffrey Nycz

发明人： Jeffrey Nycz

IPC分类号： A61F2/28

CPC分类号： A61N1/05 ,  A61F2/30744 ,  A61F2/30771 ,  A61F2/34 ,  A61F2002/2817 ,  A61F2002/2867 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30677 ,  A61F2002/30678 ,  A61F2002/3081 ,  A61F2210/0004 ,  A61F2310/00365 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/622 ,  A61N1/0568

摘要： An acetabular cup having one or more osteoinductive formulations, wherein each osteoinductive formulation comprises one or more osteoinductive agent(s). In one embodiment of the invention, the acetabular cup comprises a porous coating into which the osteoinductive formulation is impregnated. In another embodiment of the invention, the acetabular cup comprises microchambers into which the osteoinductive formulation is sealed with a biodegradable or current responsive polymer. The osteoinductive formulations may be available in immediate or sustained release formulations. The invention further relates to preventing and treating osteolytic lesions formed following implantation of an acetabular cup during hip replacement surgery.

摘要翻译： 一种具有一种或多种成骨诱导剂的髋臼杯，其中每种骨诱导性制剂包含一种或多种骨诱导剂。 在本发明的一个实施方案中，髋臼杯包括多孔涂层，其中浸渍了骨诱导制剂。 在本发明的另一个实施方案中，髋臼杯包括微生物，其中骨诱导制剂用可生物降解或电流响应的聚合物密封在其中。 骨诱导制剂可以立即或持续释放制剂。 本发明还涉及预防和治疗在髋关节置换手术期间植入髋臼杯后形成的溶骨性病变。

公开(公告)号：US06955657B1

公开(公告)日：2005-10-18

申请号：US10038788

申请日：2001-12-31

申请人： William Earl Webler

发明人： William Earl Webler

IPC分类号： A61M25/00 ,  A61M31/00 ,  A61M37/00 ,  A61N1/00 ,  A61N1/04 ,  A61N1/05

CPC分类号： A61M25/0084 ,  A61N1/0568

摘要： A guide catheter and a needle catheter are disclosed. The guide catheter construction provides for maximum articulation of the deflectable tip and maximum torque response during rotation. The needle catheter may include a release mechanism that imparts a sudden force to the needle in order to facilitate tissue penetration.

摘要翻译： 公开了引导导管和针导管。 引导导管结构提供可旋转尖端的最大关节和旋转期间的最大扭矩响应。 针导管可以包括向针施加突然的力以释放组织穿透的释放机构。

公开(公告)号：US20050137671A1

公开(公告)日：2005-06-23

申请号：US10745302

申请日：2003-12-23

申请人： Lili Liu ,  Randy Westlund ,  Steven Girouard

发明人： Lili Liu ,  Randy Westlund ,  Steven Girouard

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

摘要翻译： 心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。 引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。 引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。 管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。 管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。 可导向的管心针允许心内区域的电生理作图。 中空针允许将化学，生物化学和/或生物物质递送至心内区域。

公开(公告)号：US20050131509A1

公开(公告)日：2005-06-16

申请号：US10738647

申请日：2003-12-16

申请人： Liliana Atanassoska ,  Ronald Heil ,  David Flynn

发明人： Liliana Atanassoska ,  Ronald Heil ,  David Flynn

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/0568

摘要： A method includes sandblasting an electrode surface, applying a conductive oxide precursor solution to the electrode surface, and heating the electrode for at least 5 minutes at a temperature between 350 degrees C. and 550 degrees C. to convert the precursor solution into an oxide coating. One method includes applying a composite material including a conductive component and a non-conductive component to an electrode and curing the composite material to form a coating on the electrode. One method includes providing a metallic oxide coating on an electrode surface and applying a galvanostatic treatment to the electrode to increase the effective surface area of the metallic oxide coating.

摘要翻译： 一种方法包括喷镀电极表面，将导电氧化物前体溶液施加到电极表面，并在350摄氏度至550摄氏度之间的温度下将电极加热至少5分钟，以将前体溶液转化为氧化物涂层 。 一种方法包括将包含导电组分和非导电组分的复合材料施加到电极上并固化复合材料以在电极上形成涂层。 一种方法包括在电极表面上提供金属氧化物涂层并对电极施加恒电流处理以增加金属氧化物涂层的有效表面积。

公开(公告)号：US06889092B2

公开(公告)日：2005-05-03

申请号：US10034503

申请日：2001-12-28

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr.

IPC分类号： A61N1/05

CPC分类号： A61N1/0568 ,  A61N1/056

摘要： A lead having an electrode assembly has a high impedance electrode. The high impedance electrode includes a partially insulated sleeve electrode or a wire filament. The high impedance electrode includes an exposed surface of less than 1.2 mm2. One or more eluting drugs are disposed adjacent to the high impedance electrode.

摘要翻译： 具有电极组件的引线具有高阻抗电极。 高阻抗电极包括部分绝缘的套管电极或电线丝。 高阻抗电极包括小于1.2mm 2的暴露表面。 一个或多个洗脱药物设置在高阻抗电极附近。

公开(公告)号：US06889091B2

公开(公告)日：2005-05-03

申请号：US10094437

申请日：2002-03-06

申请人： Douglas S. Hine ,  Vicki L. Bjorklund ,  John L. Sommer

发明人： Douglas S. Hine ,  Vicki L. Bjorklund ,  John L. Sommer

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0568 ,  A61N2001/0585

摘要： A medical electrical lead, which may be useful in coupling an implantable medical device, is comprised of an elongate body having first and second spaced apart lumens. A conductor and an electrode are associated with the first lumen, and the second lumen is multi-purpose. The second lumen may be used to guide the lead and to introduce various fluids into the venous system. The second lumen may at various times be used to introduce vasodilation solutions, contrast fluids and adhesives into the venous system.

摘要翻译： 可用于联接可植入医疗装置的医用电气引线包括具有第一和第二间隔开的腔的细长体。 导体和电极与第一管腔相关联，第二管腔是多用途的。 第二管腔可用于引导引流并将各种流体引入静脉系统。 第二管腔可以在不同时间用于将血管舒张溶液，造影液和粘合剂引入静脉系统。

公开(公告)号：US20050059999A1

公开(公告)日：2005-03-17

申请号：US10663570

申请日：2003-09-15

申请人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

发明人： Luc Mongeon ,  Jesus Casas-Bejar ,  H. Markowitz ,  Daisy Cross ,  Janelle Blum ,  Michael Ebert ,  Timothy Laske

IPC分类号： A61K48/00 ,  A61N1/05 ,  A61N1/362

CPC分类号： A61N1/0568 ,  A61K48/0008 ,  A61K48/0041 ,  A61K48/0083

摘要： Delivery of genetic material to a stimulation site causes transgene expression by tissue at the stimulation site. In some embodiments, the delivered genetic material causes increased expression of proteins, such as connexins, gap junctions, and ion channels, to increase the conductivity of the tissue at the stimulation site. In some embodiments, the delivered genetic material causes expression of a metalloproteinase, an anti-inflammatory agent, or an immunosuppressant agent. Genetic material is delivered to the stimulation site via a stimulation lead. A stimulation lead for delivering genetic material to a stimulation site includes a chamber that contains a polymeric matrix. The matrix absorbs the genetic material and elutes the genetic material to the stimulation site.

摘要翻译： 将遗传物质递送至刺激部位会在刺激部位引起组织的转基因表达。 在一些实施方案中，递送的遗传物质导致蛋白质（例如连接蛋白，间隙连接和离子通道）的表达增加，以增加刺激部位组织的电导率。 在一些实施方案中，递送的遗传物质导致金属蛋白酶，抗炎剂或免疫抑制剂的表达。 遗传物质通过刺激引线输送到刺激部位。 用于将遗传物质递送至刺激部位的刺激引线包括含有聚合物基质的腔室。 基质吸收遗传物质并将遗传物质洗脱到刺激部位。