公开(公告)号：US20110097787A1

公开(公告)日：2011-04-28

申请号：US12737332

申请日：2009-06-30

Applicant: Seishi Yamashita

Inventor： Seishi Yamashita

IPC: C12M1/00

CPC classification number: C12M41/14 ,  B01L1/025 ,  G01N2035/00356 ,  G01N2035/0425

Abstract: Constant-temperature equipment wherein maintenance is facilitated with the least failure, and highly reliable culturing and testing can be carried out. Mechanical and electrical structures are eliminated from the inside of a temperature-controlled chamber (15) by using a non-contact magnetic arrangement as a drive transmission for a sample table (5) and a sample table drive mechanism (6), thus reducing failure and enhancing maintainability. In addition, a conveyance mechanism (11) is provided with a pass box adjacent which sliding shielding plates (9) are stacked vertically, and the shielding plates (9) are linked with the conveyance mechanism (11) by an engaging means provided in the conveyance mechanism (11) to allow the plates to be opened and closed by a travel mechanism (12), thus simplifying the structure and minimizing change in atmosphere during conveying. The sample table drive mechanism (6) and the conveyance mechanism (11) can be attached removably to the temperature-controlled chamber (15) to permit sterilization at high temperature.

Abstract translation: 能够以最小的故障促进维护的恒温设备，并且可以进行高度可靠的培养和测试。 通过使用非接触磁性装置作为样品台（5）和样品台驱动机构（6）的驱动传动装置，从温度控制室（15）的内部消除机械和电气结构，从而减少故障 并提高可维护性。 另外，输送机构11设置有滑动屏蔽板（9）垂直堆叠的通过箱，并且所述遮蔽板（9）通过设置在所述输送机构（11）中的卡合机构与所述输送机构 输送机构（11），通过移动机构（12）使板打开和关闭，从而简化结构并使输送过程中的气氛变化最小化。 样品台驱动机构（6）和输送机构（11）可以可移除地附接到温度控制室（15）以允许在高温下灭菌。

公开(公告)号：US20240216906A1

公开(公告)日：2024-07-04

申请号：US18422738

申请日：2024-01-25

Applicant: Mitegen, LLC

Inventor： Richard Jayne ,  David Closs ,  Benjamin A. Apker ,  Robert E. Thorne

IPC: B01L1/02 ,  B01L3/00 ,  B01L7/00 ,  G02B21/06 ,  G02B27/00

CPC classification number: B01L1/025 ,  B01L3/508 ,  B01L7/00 ,  G02B21/06 ,  G02B27/0006 ,  B01L2300/0663 ,  B01L2300/123 ,  B01L2300/18

Abstract: Humidified sample preparation station for serial crystallography according to one embodiment is a humidified enclosure that delivers relative humidities above 95% and preferably above 97% in standard operation, and that can allow microscope observation of samples within. Humidified sample preparation station for serial crystallography can be used for preparation of protein crystal samples for examination using X-rays and for protein structure determination by X-ray crystallography, involving addition of liquid to the sample and removal of liquid from the sample using vacuum or suction.

公开(公告)号：US11925931B2

公开(公告)日：2024-03-12

申请号：US17397383

申请日：2021-08-09

Applicant: Mitegen, LLC

Inventor： Richard Jayne ,  David Closs ,  Benjamin A. Apker ,  Robert E. Thorne

IPC: B01L1/02 ,  B01L3/00 ,  B01L7/00 ,  G02B21/06 ,  G02B27/00

CPC classification number: B01L1/025 ,  B01L3/508 ,  B01L7/00 ,  G02B21/06 ,  G02B27/0006 ,  B01L2300/0663 ,  B01L2300/123 ,  B01L2300/18

Abstract: Humidified sample preparation station for serial crystallography according to one embodiment is a humidified enclosure that delivers relative humidities above 95% and preferably above 97% in standard operation, and that can allow microscope observation of samples within. Humidified sample preparation station for serial crystallography can be used for preparation of protein crystal samples for examination using X-rays and for protein structure determination by X-ray crystallography, involving addition of liquid to the sample and removal of liquid from the sample using vacuum or suction.

公开(公告)号：US20240066164A1

公开(公告)日：2024-02-29

申请号：US18261142

申请日：2021-12-15

Applicant: Syntegon Technology GmbH

Inventor： Benjamin Hoffmann ,  Albrecht Kühnle ,  Thomas Kosian

IPC: A61L2/20 ,  A61L2/26 ,  B01L1/02 ,  F24F3/167

CPC classification number: A61L2/208 ,  A61L2/26 ,  B01L1/025 ,  F24F3/167 ,  A61L2202/11 ,  A61L2202/122 ,  A61L2202/123 ,  A61L2202/14

Abstract: The invention relates to an isolator (10) for processing medical substances and a method for decontamination of an isolator (10).

公开(公告)号：US20190204250A1

公开(公告)日：2019-07-04

申请号：US16063070

申请日：2016-12-18

Applicant: VRIJE UNIVERSITEIT BRUSSEL ,  KATHOLIEKE UNIVERSITEIT LEUVEN

Inventor： Yves VAN INGELGEM ,  Bart LANDUYT ,  Sven VERGUTS

IPC: G01N27/02 ,  G01N33/483 ,  B01L3/00

CPC classification number: G01N27/026 ,  B01L1/025 ,  B01L3/5085 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  G01N33/4836

Abstract: A system for measuring electrical characteristics of bioparticles is described. The system comprises an incubator for performing electrochemical measurements in a defined environment and a substrate holder positioned in said incubator for holding a substrate comprising a plurality of wells. The system is furthermore configured for continuously or regularly measuring electrochemical data. The system also comprises a processing means for comparing the continuously or regularly measured electrochemical data with reference data and for determining a moment for adding an active compound based on said comparison.

公开(公告)号：US20180171280A1

公开(公告)日：2018-06-21

申请号：US15821096

申请日：2017-11-22

Applicant: GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE ADMINISTRATOR OF THE U.S. ENVIRONMENTAL PROTEC

Inventor： Mark HIGUCHI ,  Jose ZAVALA-MENDEZ ,  Earl Puckett

IPC: C12M1/00 ,  C12N5/00 ,  C12M1/12 ,  C12N5/071 ,  G01N33/483 ,  B01L1/02

CPC classification number: C12M41/14 ,  B01L1/025 ,  B01L7/54 ,  B01L2300/047 ,  B01L2300/048 ,  B01L2300/0829 ,  C12M25/02 ,  C12N5/0068 ,  C12N5/0688 ,  C12N2533/54 ,  G01N33/4833 ,  G01N33/5014

Abstract: An vitro air-liquid interface (ALI) exposure of cultured cells makes it possible to examine the toxicological properties of the tested air. A method for evaluating effect of a polluting air stream comprises the steps of exposing cells to a membrane until adhesion of the cells has occurred, feeding cells periodically until there is a confluent monolayer of cells on said membranes, aspirating off non-adherent cells, applying fresh media, exposing the cells to over-head stream containing pollutants, removing the cells from the membranes that have been exposed to the over-head stream, then measuring the cells' response to toxins in the over-head stream.

公开(公告)号：US09993815B2

公开(公告)日：2018-06-12

申请号：US14890223

申请日：2012-07-20

Applicant: Jeroen Immerzeel ,  Christopher Procyshyn ,  Steve Sang Joon Park ,  Ross M. Gold

Inventor： Jeroen Immerzeel ,  Christopher Procyshyn ,  Steve Sang Joon Park ,  Ross M. Gold

IPC: B01L1/02 ,  B25J21/00 ,  C12M1/00 ,  C12M1/12 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  G01N35/00

CPC classification number: B01L1/025 ,  A61L2/07 ,  A61L2/16 ,  A61L2/24 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/0832 ,  B25J21/00 ,  C12M29/00 ,  C12M37/02 ,  C12M41/14 ,  G01N35/0099 ,  G01N2035/00277

Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated.

公开(公告)号：US20170232434A1

公开(公告)日：2017-08-17

申请号：US15501049

申请日：2015-04-07

Applicant: AIRTECK JAPAN, LTD. ,  JAPAN TISSUE ENGINEERING CO., LTD.

Inventor： Hiroshi GOTO ,  Yosuke OTSUKA ,  Shinya HIRASAWA ,  Ken-ichiro HATA ,  Yukio MORI ,  Makoto SUGIURA

IPC: B01L1/02

CPC classification number: B01L1/025 ,  B01L1/04 ,  B01L2300/0681 ,  B01L2300/10 ,  B08B15/023 ,  B25H1/20 ,  F24F7/06

Abstract: A safety cabinet has a second operation chamber in a first operation chamber and into which clean air is supplied, a second suction opening for sucking in air in the second operation chamber and a portion of the air in the first operation chamber, and a second operation opening part that is provided facing a first operation opening part and communicates the second operation chamber with the first operation chamber. Airflow containment (air barrier) is doubled with respect to the outside of a safety cabinet. In cases where decontamination and disinfection operations are carried out according to the changeover procedures, intensive decontamination and disinfection of the second operation chamber is sufficient, and decontamination and disinfection of the first operation chamber is hardly required. Decontamination and disinfection operations in the changeover procedures and the like can be carried out in a greatly reduced time.

公开(公告)号：US20160160167A1

公开(公告)日：2016-06-09

申请号：US15046061

申请日：2016-02-17

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Koichi KOBAYASHI ,  Yasuhiko YOKOI ,  Hironobu SEKINE

IPC: C12M1/12 ,  C12M1/00

CPC classification number: C12M37/02 ,  B01L1/025 ,  B01L1/04 ,  B25J21/02 ,  C12M29/04 ,  C12M29/06 ,  C12M31/00 ,  C12M31/02 ,  C12M37/00 ,  C12M41/14

Abstract: A working chamber including: a body case including a work space in an interior thereof; a supply unit configured to supply gas through a supply filter provided at the upper front of the work space; a louver that guides gas to a back surface side of the work space after the gas passes through the supply filter; and an illuminating means positioned lower than the louver and in front of the louver, at least one surface of the louver, which faces the illuminating means, being a reflection surface.

Abstract translation: 一种工作室，包括：主体壳体，其内部具有工作空间; 供给单元，被配置为通过设置在所述工作空间的上前部的供给过滤器供给气体; 在气体通过供给过滤器之后将气体引导到工作空间的背面侧的百叶窗; 以及位于百叶窗下方并且在百叶窗前方的照明装置，面对照明装置的百叶窗的至少一个表面是反射面。

公开(公告)号：US09333498B2

公开(公告)日：2016-05-10

申请号：US14964112

申请日：2015-12-09

Applicant: PANASONIC HEALTHCARE HOLDINGS CO., LTD.

Inventor： Ayako Michida

IPC: B01L1/02 ,  C12M1/12 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36

CPC classification number: B01L1/025 ,  B01L1/02 ,  B01L2300/023 ,  B01L2300/027 ,  C12M37/00 ,  C12M41/14 ,  C12M41/30 ,  C12M41/34 ,  C12M41/48

Abstract: An isolator system including: a body case; a sterilizing unit; an air conditioning unit; a display unit; a control unit; and a storage unit, the control unit being configured to, after startup, confirm whether a concentration of a sterilizing substance in a work area is equal to or less than a predetermined concentration, or not, and when the concentration of the sterilizing substance exceeds the predetermined concentration, store a high concentration flag in the storage unit, and thereafter, check an operation of the air conditioning unit, if there is no problem with the operation of the air conditioning unit, confirm whether the flag is stored, and when the flag is stored, operate the air conditioning unit for a predetermined time period, to lower the concentration of the sterilizing substance, and when the flag is not stored, end check of the operation of the air conditioning unit.

Abstract translation: 一种隔离器系统，包括：主体箱; 灭菌单位 空调机组; 显示单元; 一个控制单元; 以及存储单元，所述控制单元被配置为在启动之后确认工作区域中的灭菌物质的浓度是否等于或小于预定浓度，并且当所述灭菌物质的浓度超过 预定浓度，将高浓度标志存储在存储单元中，然后检查空调单元的操作，如果空调单元的操作没有问题，确认标志是否被存储，以及当标志 存储空调单元一定时间，降低灭菌物质的浓度，当不存储标志时，结束对空调单元的动作的检查。