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180 条记录 (耗时 0.053 秒)

    IMINOXYTRIAZINES AS RADICAL GENERATORS
    36.
    发明申请
    IMINOXYTRIAZINES AS RADICAL GENERATORS 有权
    作为辐射发生器的IMINOXYTRIAZINES

    公开(公告)号：US20150284604A1

    公开(公告)日：2015-10-08

    申请号：US14437246

    申请日：2013-10-22

    申请人： BASF SE

    发明人： Peter Nesvadba ,  Lucienne Bugnon Folger ,  Antoine Carroy ,  Marc Faller

    IPC分类号： C09J133/14 ,  C09D11/107

    CPC分类号： C09J133/14 ,  C07D251/30 ,  C07D251/42 ,  C07D403/14 ,  C09D11/107

    摘要： Iminoxytriazine compounds of the formula I wherein n is 1 or 2; R1 and R2 independently of each other are hydrogen, NH2, NHR5, NR5R6, COR5, COOR5, CONH2, CONHR5, CONR5R6, CN, SR5, OR5, C1-C18alkyl, C3-C12cycloalkyl, C6-C14aryl or C2-C14heteroaryl, wherein said C3-C12cycloalkyl, C6-C14aryl or C2-C14heteroaryl is unsubstituted or substituted by one or more radicals selected from the group consisting of C1-C12alkyl, C3-C12-cycloalkyl, phenyl, halogen and C1-C12 alkoxy, or R1 and R2 together with the C atom to which they are linked form a 4 to 12 membered carbocyclic or heterocyclic saturated or unsaturated ring which is unsubstituted or substituted by one or more radicals selected from the group consisting of C1-C12alkyl, C3-C12-cycloalkyl, phenyl, halogen and C1-C12 alkoxy; R3 is F, Cl, OH, OR5, SH, SR5, NH2, NHR5, NR5R6 or R1R2C═N—O—; wherein R1 and R2 in all groups R1R2C═N—O— in the compound of the formula I are identical or different; if n is 1, R4 is F, Cl, OH, OR5, SH, SR5, NH2, NHR5, NR5R6 or R1R2C═N—O—; wherein R1 and R2 in all groups R1R2C═N—O— in the compound of the formula I are identical or different; if n is 2, R4 is a difunctional group derived from a diol, diamine, aminoalcohol or mercaptoalcohol; R5 and R6 independently of each other are C1-C18alkyl, C3-C12cycloalkyl, C6-C14aryl or C2-C14heteroaryl; are suitable as radical generating agents.

    摘要翻译： 式I的亚氨基三嗪化合物，其中n为1或2; R 1和R 2彼此独立地是氢，NH 2，NHR 5，NR 5 R 6，COR 5，COOR 5，CONH 2，CONHR 5，CONR 5 R 6，CN，SR 5，OR 5，C 1 -C 18烷基，C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基， C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基是未取代的或被一个或多个选自C 1 -C 12烷基，C 3 -C 12环烷基，苯基，卤素和C 1 -C 12烷氧基的基团取代或R 1和R 2一起 与其连接的C原子形成4-12元碳环或杂环饱和或不饱和环，其未被取代或被一个或多个选自以下的基团取代：C 1 -C 12烷基，C 3 -C 12环烷基，苯基， 卤素和C 1 -C 12烷氧基; R3是F，Cl，OH，OR5，SH，SR5，NH2，NHR5，NR5R6或R1R2C = N-O-; 其中式I化合物中所有基团R1R2C = N-O-中的R1和R2相同或不同; 如果n为1，则R4为F，Cl，OH，OR5，SH，SR5，NH2，NHR5，NR5R6或R1R2C = N-O-; 其中式I化合物中所有基团R1R2C = N-O-中的R1和R2相同或不同; 如果n为2，则R4为衍生自二醇，二胺，氨基醇或巯基醇的双官能团; R 5和R 6彼此独立地是C 1 -C 18烷基，C 3 -C 12环烷基，C 6 -C 14芳基或C 2 -C 14杂芳基; 适合作为自由基产生剂。

    1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof
    37.
    发明授权
    1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof 有权
    1,3,5-三嗪-2-胺衍生物，其制备及其诊断和治疗用途

    公开(公告)号：US09115121B2

    公开(公告)日：2015-08-25

    申请号：US14364418

    申请日：2012-12-11

    申请人： SANOFI

    发明人： Joelle Arnaud ,  Martine Artiaga ,  Francis Barth ,  Laurent Hortala ,  Serge Martinez ,  Pascale Roux

    IPC分类号： C07D251/16 ,  A61K31/53 ,  C07D413/04 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D251/42

    CPC分类号： C07D413/04 ,  C07B2200/05 ,  C07D251/16 ,  C07D251/42 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

    摘要： The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.

    摘要翻译： 本发明涉及对应于式（I）的化合物，其中：-R 1表示取代的苯基; -R2表示：-a取代的苯基; - 杂芳基，所述基团是未取代的或取代的一次或多次; -R3表示基团Alk; -R4表示氢原子或（C1-C4）烷基; -R 5表示氢原子，（C 3 -C 6）环烷基或（C 1 -C 4）烷基-O-Alk; 或者R4和R5与它们所连接的氮原子一起构成选自以下的杂环基：氮杂环丁烷-1-基，吡咯烷-1-基，哌啶-1-基，吗啉-4-基; -R6表示基团-COOAlk，基团-CONH2或基团-NHSO2Alk; -Alk表示未被取代或被卤素原子取代一次或多次的（C 1 -C 4）烷基; 为碱或酸加成盐的形式。 制备过程及诊断和治疗用途。