摘要:
THE INVENTION RELATES TO A PROCESS FOR THE PRODUCTION OF CITRIC ACID WITH COMPRISES SUBJECTING A PARTIALLY DECATIONIZED CARBOHYDRATE-CONTAINING SOLUTION TO A SUBMERGED FERMENTATION WITH A CITRIC ACID PRODUCTION STRAIN OF ASPERGILLUS NIGER IN THE PRESENCE OF K4(FE(CN)6).3H2O AS AN INHIBITOR IN AN AMOUNT OF LESS THAN 500 P.P.M.
摘要:
THIS INVENTION IS ADDRESSED TO AN IMPROVED METHOD FOR THE PREPARATION OF GLUCOSE OXIDASE IN WHICH GLUCOSE OXIDASE-PRODUCING STRAINS OF THE GENERA ASPERGILLUS AND PENICILLIUM ARE CULTIVATED IN MEDIUM HAVING A LOW CARBOHYDRATE CONTENT IN WHICH THE CARBOHYDRATE HAS A DEXTROSE EQUIVALENT OF 60-85, IN THE PRESENCE OF HYDRATED MAGNESIUM SULFATE, MONOPOTASSIUM PHOSPHATE, AND A SOURCE OF ASSIMILABLE NITROGEN IN THE FORM OF A NITRATE SALT OR AN AMMONIUM SALT.
摘要:
MICROBIOLOGIC AL PROCESSES FOR HYDROXYLATING 6-SUBSTITUTED -2- ISOPROPYL-NAPHTHALENE COMPOUNDS TO THE CORRESPONDING 6-SUBSTITUTED-NAPHTHALENE PROPANOLS (E.G. 2-(6''METHOXY -2''-NAPHTYL)-1-PROPANOL; AND 2-(6''-THIOMETHYL2''-NAPHTHYL)-1-PROPANOL). THE PROCESSES ARE CHARACTERIZED BY TREATING THE 6-SUBSTITUTED-2-ISOPROPYL-NAPHTAHALENE COMPOUND WITH THE SPECIES OF THE GENUS OF FUNGI ASPERGILLUS, IDENTIFIED AS ASPERGILLUS NIGER, IN THE PRESENCE OF A NUTRIENT MEDIUM UNDER CONDITIONS CONDUCIVE TO THE MICROBIOLOGICAL AGENT. THE RESULTING PROPANOL COMPOUNDS EXHIBIT ANALGESIC, ANTI-INFLAMMATORY, AND ANTI-PYRETIC ACTIVITIES IN MAMMALS AND ACCORDINGLY HAVE UTILITY WHERE SUCH AGENTS ARE INDICATED. THE PROPANOL COMPOUNDS CAN ALSO BE CONVERTED INTO THE CORRESPONDING PROPIONIC ACID COMPOUNDS WHICH ALSO HAVE UTILITY AS ANTI-UNFLAMMATORY, ANALGESIC AND ANTI-PYRETIC AGENTS IN TREATMENT OF MAMMALS.