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    3,4-BICYCLIC PYRROLIDINE ANTIVIRALS
    31.
    发明申请
    3,4-BICYCLIC PYRROLIDINE ANTIVIRALS 审中-公开
    3,4-双环吡啶类抗生素

    公开(公告)号：US20090326019A1

    公开(公告)日：2009-12-31

    申请号：US12482804

    申请日：2009-06-11

    申请人： Yat Sun Or ,  Jiang Long ,  Ce Wang ,  Lu Ying ,  Yao-Ling Qiu

    发明人： Yat Sun Or ,  Jiang Long ,  Ce Wang ,  Lu Ying ,  Yao-Ling Qiu

    IPC分类号： A61K31/427 ,  C07D417/04 ,  C12N7/06 ,  A61P31/12

    CPC分类号： C07D417/04 ,  A61K31/427 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral (particularly HCV) infection in a subject in need of such therapy with said compounds.

    摘要翻译： 本发明公开了式（I）化合物或其药学上可接受的盐，酯或前药：其抑制含RNA病毒，特别是丙型肝炎病毒（HCV）。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。 本发明涉及上文所示的新的抗病毒化合物，包含这些化合物的药物组合物，以及用于治疗或预防需要用所述化合物治疗的受试者中的病毒（特别是HCV）感染的方法。

    IMMUNOCONJUGATES COMPRISING CD4 AND IMMUNOGLOBIN MOLECULES FOR THE TREATMENT OF HIV INFECTION
    32.
    发明申请
    IMMUNOCONJUGATES COMPRISING CD4 AND IMMUNOGLOBIN MOLECULES FOR THE TREATMENT OF HIV INFECTION 审中-公开
    包含用于治疗HIV感染的CD4和免疫球蛋白分子的免疫球蛋白

    公开(公告)号：US20090285815A1

    公开(公告)日：2009-11-19

    申请号：US12053506

    申请日：2008-03-21

    申请人： James Arthos ,  Claudia Cicala ,  Anthony S. Fauci

    发明人： James Arthos ,  Claudia Cicala ,  Anthony S. Fauci

    IPC分类号： A61K39/395 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  C12N5/08 ,  C12N7/06 ,  A61P37/04

    CPC分类号： C07K14/70514 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

    摘要： Nucleic acids encoding recombinant CD4-fusion proteins are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion of the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C terminus of the heavy chain of an IgA antibody or a tailpiece from a C terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4-fusion proteins.

    摘要翻译： 编码重组CD4融合蛋白的核酸在本文中公开，其包括在其C-末端与包含铰链区和哺乳动物免疫球蛋白重链的恒定结构域的免疫球蛋白的一部分连接的CD4多肽。 IgG的部分在其C末端与包含来自IgA抗体的重链的C末端的尾部的多肽或来自IgM抗体的重链的C末端的尾端融合。 本文还公开了使用这些CD4融合蛋白的方法。

    NOVEL ATTENUATED POLIOVIRUS
    34.
    发明申请
    NOVEL ATTENUATED POLIOVIRUS 有权
    高血压病毒

    公开(公告)号：US20090246216A1

    公开(公告)日：2009-10-01

    申请号：US12405068

    申请日：2009-03-16

    申请人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

    发明人： Eckard Wimmer ,  Jeronimo Cello ,  Aniko Paul ,  Hidemi Toyoda ,  Jiang Yin

    IPC分类号： A61K39/13 ,  C12N7/01 ,  A61P35/00 ,  C12N7/06

    CPC分类号： C12N7/00 ,  A61K35/768 ,  C12N2770/32332 ,  C12N2770/32361 ,  C12N2800/30 ,  C12N2840/203

    摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.

    摘要翻译： 在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。 稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

    FLUORINATED MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS
    35.
    发明申请
    FLUORINATED MACROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS 有权
    氟化大环化合物作为丙型肝炎病毒抑制剂

    公开(公告)号：US20090238794A1

    公开(公告)日：2009-09-24

    申请号：US12407461

    申请日：2009-03-19

    申请人： Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    发明人： Yonghua Gai ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/21 ,  C07K5/12 ,  A61K38/12 ,  A61P31/12 ,  C12N7/06

    CPC分类号： C07K5/0827 ,  A61K38/00

    摘要： The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

    Method of producing baculovirus
    37.
    发明授权
    Method of producing baculovirus 失效
    产生杆状病毒的方法

    公开(公告)号：US07521219B2

    公开(公告)日：2009-04-21

    申请号：US10578197

    申请日：2004-11-10

    申请人： Steven Reid ,  Linda Lua

    发明人： Steven Reid ,  Linda Lua

    IPC分类号： C12N7/00 ,  C12N7/02 ,  C12N7/06 ,  A01N63/00

    CPC分类号： C12N7/00 ,  C12N2710/14151

    摘要： The present invention is directed to a method for producing commercial quantities of baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in caterpillar larvae and large numbers of viral particles with serial passages in cell culture. A two step method was developed by initially producing infectious virus in caterpillar larvae and then using the resultant infectious virus as an inoculum for a limited number of serial passages in cell culture so to produce large amounts of infectious baculovirus.

    摘要翻译： 本发明涉及一种生产商业数量的杆状病毒的方法，该方法涉及在毛虫幼虫中产生具有感染性杆状病毒的闭塞体和在细胞培养物中连续传代的大量病毒颗粒的方法的组合。 通过最初在毛虫幼虫中产生感染性病毒，然后将所得的感染性病毒作为细胞培养物中有限数量的连续传代的接种物，开发出两步法，从而产生大量的感染性杆状病毒。

    Anti-Viral Compositions
    40.
    发明申请
    Anti-Viral Compositions 审中-公开
    抗病毒组合物

    公开(公告)号：US20080299131A1

    公开(公告)日：2008-12-04

    申请号：US11631088

    申请日：2005-06-28

    申请人： Geoffrey Lilley Smith ,  Gemma Chevonne Carter ,  Mansun Law ,  Michael Stanley Hollinshead

    发明人： Geoffrey Lilley Smith ,  Gemma Chevonne Carter ,  Mansun Law ,  Michael Stanley Hollinshead

    IPC分类号： A61K39/395 ,  C12N7/06 ,  A61P31/12

    CPC分类号： A61K31/726 ,  A61K39/395 ,  A61K2300/00

    摘要： The invention provides a composition comprising for simultaneous, sequential or separate administration a) a polyanion; and b) an antibody reactive against an antigen on the surface of an intracellular form of a virus, which virus has an extracellular form that is surrounded by one lipid membrane more than the intracellular form. The present inventors have found that the compositions according to the invention comprising an antibody and a polyanion can neutralize virus infectivity more efficiently than other compositions reported hitherto.

    摘要翻译： 本发明提供一种组合物，其包含用于同时，顺序或分别给药a）聚阴离子; 和b）对细胞内形式的病毒表面上的抗原具有反应性的抗体，该病毒具有比一种脂质膜多于细胞内形式包围的细胞外形式。 本发明人已经发现，包含抗体和聚阴离子的根据本发明的组合物可以比迄今报道的其它组合物更有效地中和病毒感染性。