公开(公告)号：US11623938B2

公开(公告)日：2023-04-11

申请号：US17790191

申请日：2020-09-02

申请人： KYLONOVA (XIAMEN) BIOPHARMA CO., LTD.

发明人： Kunyuan Cui ,  Shengjun Wang ,  Yanchun Du

IPC分类号： C07H15/18 ,  A61P1/16 ,  C07H1/00

摘要： The present invention belongs to the field of biomedicine, specifically relates to the field of targeting medicine. More specifically, the present invention relates to a liver-targeting compound having thyroid hormone receptor agonist characteristics and a pharmaceutical composition thereof. The compound is a compound represented by formula (1). The compound can be used for treating and/or preventing diseases caused by thyroid hormone dysregulation, and can also effectively reduce lipids in plasma and liver cells.

公开(公告)号：US20230086900A1

公开(公告)日：2023-03-23

申请号：US18051783

申请日：2022-11-01

申请人： Sweet Green Fields International Co., Limited,

发明人： Jingang Shi ,  Hansheng Wang ,  Mingming Deng ,  Jien Ding ,  Yanyan Wu

IPC分类号： A23L27/30 ,  C07H1/00 ,  C07H15/256

摘要： The invention describes compositions that include a stevia sweetener and a salt of a steviol glycoside, wherein the concentration of the components provide an improved taste profile where bitterness, after taste and/or lingering of the stevia sweetener is decreased or eliminated.

公开(公告)号：US20230070069A1

公开(公告)日：2023-03-09

申请号：US17718990

申请日：2022-04-12

申请人： Geron Corporation

发明人： Jale MUSLEHIDDINOGLU ,  Dinesh GALA ,  Jennifer Elizabeth ALBANEZE-WALKER

IPC分类号： C07H1/00

摘要： The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3′-amino group of the support-bound oligonucleotide, coupling with a 5′-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3′-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.

公开(公告)号：US11582994B2

公开(公告)日：2023-02-21

申请号：US16770224

申请日：2018-12-07

申请人： Chr. Hansen HMO GmbH

发明人： Stefan Jennewein

IPC分类号： A23L33/125 ,  A23L33/135 ,  A23L33/00 ,  A23P10/40 ,  A23C9/20 ,  A23L3/46 ,  B01D9/00 ,  B01D61/02 ,  B01D61/14 ,  B01D61/42 ,  C07H1/06 ,  C07H3/06 ,  A23L5/20 ,  A61K35/741 ,  A61K47/26 ,  B01D61/58 ,  A23L33/18 ,  C12N9/12 ,  A23L29/00 ,  C07H1/00 ,  C12P17/18 ,  C12P19/00

摘要： Disclosed is a method for the manufacture of a spray-dried powder consisting essentially of 3-fucosyllactose, the spray-dried powder, its use for the manufacture of nutritional compositions, and nutritional compositions containing the spray-dried powder.

公开(公告)号：US11572380B2

公开(公告)日：2023-02-07

申请号：US16718702

申请日：2019-12-18

申请人： NIHON SHOKUHIN KAKO CO., LTD.

发明人： Norihisa Hamaguchi ,  Hitoshi Takaguchi ,  Yoshinori Fujimoto ,  Yutaka Kimoto ,  Hirokazu Hirai ,  Masayasu Takada

IPC分类号： C07H3/00 ,  A23L2/60 ,  A23L2/52 ,  A23L2/56 ,  C07H1/00 ,  C12C5/02 ,  A23C9/13 ,  A23G3/42 ,  A23G9/34 ,  A23C13/12 ,  A23G4/10 ,  A23C9/154 ,  A21D2/18 ,  A23L33/21 ,  A23L15/00 ,  A23L33/10 ,  A23L33/25 ,  C12C11/00

摘要： An object of the present invention is to provide a method for producing a saccharide polycondensate which is inexpensive and is applicable to a food or beverage product. Disclosed is a method for producing a saccharide polycondensate, which comprises carrying out a saccharide polycondensation reaction in the presence of activated carbon.

公开(公告)号：US20230024003A1

公开(公告)日：2023-01-26

申请号：US17770520

申请日：2020-08-28

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Ikuya OSHIRO ,  Tatsuya SAITO ,  Hideki IHARA

IPC分类号： C07H1/00 ,  C07H19/06 ,  C07H21/00 ,  C07C317/18 ,  C07C315/04

摘要： The present invention provides an amidite compound capable of improving a yield and a purity of a polyoligonucleotide, a glycoside compound as an intermediate thereof, and a production method for a polynucleotide using the amidite compound. The present invention also provides an amidite compound of formula (1) capable of improving a yield and a purity of a polyoligonucleotide, a glycoside compound of formula (10) (in formulae (10) and (1), Ba, Ra, Rb, Rc, G1, G2, and G3 are as defined in the description, and R is represented by the following formulae), and a production method for a polynucleotide using the amidite compound.

公开(公告)号：US20230014428A1

公开(公告)日：2023-01-19

申请号：US17574610

申请日：2022-01-13

申请人： Miltenyi Biotec B.V. & Co. KG

发明人： Mong Sano MARMA ,  Sameh Soliman ,  Michel PERBOST ,  Xiao-Pei GUAN

IPC分类号： C07H1/00 ,  C07H19/20 ,  C07H19/10

摘要： The invention is directed to a method for production of a deoxynucleotide triphosphate according to general formula (7) wherein B is a nucleobase and R is an alkyl group having 1 to 4 carbon atoms and n is an integer from 1 to 10 by reaction of reaction precursor of compound 6 wherein R1, R2 and R3 are independently H, O-Alkyl with alkyl residues having 1 to 4 carbon atoms or halogen and n is an integer from 1 to 10 with dialkyl(alkylthio)sulfonium salt (8B) wherein R4, R5 R6 are independently alkyl residues having 1 to 4 carbon atoms and X is selected from the group consisting of BF4−, F−, Cl−, Br−, I−, SO42−, SO32− in aqueous solution having a pH between 3 and 7.

公开(公告)号：US11548910B2

公开(公告)日：2023-01-10

申请号：US15776709

申请日：2016-11-17

申请人： NISSAN CHEMICAL CORPORATION

发明人： Yudai Sugawara

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07H19/10 ,  C07H19/20 ,  C07H1/00 ,  C07D405/06

摘要： The invention provides a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. The oligonucleotide production method includes a step of subjecting a nucleoside or oligonucleotide having a pseudo solid phase-protecting group in at least one location selected from the group consisting of 2′-position, 3′-position, 5′-position and a nucleobase moiety and having a 5′-hydroxyl group or a 3′-hydroxyl group, to H-phosphonation to convert the 5′-hydroxyl group or the 3′-hydroxyl group into an H-phosphonated form.

公开(公告)号：US20230002435A1

公开(公告)日：2023-01-05

申请号：US17820921

申请日：2022-08-19

申请人： Conagen Inc.

发明人： Guohong Mao ,  Xiaodan Yu

IPC分类号： C07H15/24 ,  C07H1/00 ,  C12N9/10 ,  A23L2/60 ,  C07H15/256 ,  C12P19/56 ,  A23L27/30 ,  A23L33/10 ,  C12P19/18

摘要： Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside G (Reb G), rebaudioside KA (Reb KA), rebaudioside V (Reb V) and rebaudioside (Reb W).

公开(公告)号：US11542294B2

公开(公告)日：2023-01-03

申请号：US16483148

申请日：2018-03-22

申请人： Roche Innovation Center Copenhagen A/S

发明人： Michael Meldgaard ,  Marianne B. Mogensen ,  Dennis Jul Hansen

IPC分类号： C07H21/00 ,  C07H1/00 ,  C07H1/06

摘要： Methods for cleaving oligonucleotides from a solid support are described as are methods for synthesizing an oligonucleotide on a solid support and subsequently cleaving the oligonucleotide from the solid support. In the methods, the 3′ nucleoside of the oligonucleotide attached to the solid support is a LNA nucleoside. The method entail treating the bound oligonucleotide with a concentrated ammonium hydroxide solution for about 30 minutes to about 6 hours.