公开(公告)号：US09779769B2

公开(公告)日：2017-10-03

申请号：US14952852

申请日：2015-11-25

申请人： Infinitum Solutions, Inc.

发明人： Juergen Heidmann

IPC分类号： G01R33/26 ,  G11B5/455 ,  G01N21/64 ,  G11B5/012 ,  G01N24/10 ,  G01R33/32 ,  G11B5/00

CPC分类号： G11B5/455 ,  G01N21/64 ,  G01N21/6489 ,  G01N24/10 ,  G01N2201/0612 ,  G01R33/323 ,  G11B5/012 ,  G11B2005/0021

摘要： A diamond probe is suitable to be attached to an Atomic Force Microscope and is created with a tip that incorporates a one or more Nitrogen Vacancy (NV) centers located near the end of the tip. The probe arm acts as an optical waveguide to propagate the emission from the NV center with high efficiency and a beveled end directs excitation light to the NV center and directs photoluminescence light emanating from the NV center into the probe arm. The light source (or a portion of the light source), a detector, as well as an RF antenna, if used, may be mounted to the probe arm. The probe with integrated components enable excitation of photoluminescence in the NV center as well as optically detected Electron Spin Resonance (ODMR) and temperature measurements, and may further serve as a light probe utilizing the physical effect of Stimulated Emission Depletion (STED).

公开(公告)号：US20160370308A1

公开(公告)日：2016-12-22

申请号：US15105956

申请日：2014-12-18

申请人： Institut de Radioprotection et de Surete Nucleaire

发明人： François Trompier

IPC分类号： G01N24/10 ,  A61N5/10 ,  G01N33/483

CPC分类号： G01N24/10 ,  A61N5/1071 ,  G01N33/4833 ,  G01N33/6893

摘要： The invention relates to a radiation-induced radical species characterized in that it has, when measuring a biological nail, hair, or stratum corneum tissue sample by continuous wave EPR spectroscopy at ambient temperature: a Lande factor of 2.004; during Q band measurements at ambient temperature, a minimum signal intensity and a maximum signal intensity, said intensities being reached for magnetic field values separated by 1.8 mT; during X band measurements, a signal forming a singlet; and at the highest frequency, a signal having Lande factor anisotropy. The invention also relates to methods suitable for the identified radical species and intended for preparing a sample, analyzing the measured signal, and estimating a received dose.

摘要翻译： 本发明涉及辐射诱导的自由基物质，其特征在于当在环境温度下通过连续波EPR光谱测量生物指甲，毛发或角质层组织样品时，其具有2.004的兰德因子; 在环境温度的Q波段测量期间，最小信号强度和最大信号强度，对于分离为1.8mT的磁场值达到所述强度; 在X波段测量期间，形成单峰的信号; 并且在最高频率处，具有Lande因子各向异性的信号。 本发明还涉及适合于鉴定的自由基物种并用于制备样品，分析测量的信号和估计接收的剂量的方法。

公开(公告)号：US09255901B2

公开(公告)日：2016-02-09

申请号：US13061423

申请日：2009-08-28

申请人： Harold M. Swartz ,  Jiang Gui ,  Xiaoming He ,  Piotr Leniewski ,  Roberto J. Nicolalde Flores ,  Benjamin B. Williams ,  Dean E. Wilcox

发明人： Harold M. Swartz ,  Jiang Gui ,  Xiaoming He ,  Piotr Leniewski ,  Roberto J. Nicolalde Flores ,  Benjamin B. Williams ,  Dean E. Wilcox

IPC分类号： A61B1/24 ,  G01R33/30 ,  A61B10/00 ,  A61B5/055 ,  A61B6/00 ,  G01N24/10 ,  G01R33/60

CPC分类号： G01N24/10 ,  G01R33/60

摘要： An apparatus and method for triaging patients according to radiation exposure measures electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. In vivo, radiation induced spectra are obtained from intact fingernails, toenails, or teeth placed within a magnet and with pickup coils over nails between the cut edge at the end of the fingernail and proximal skin or placed adjacent to at least one tooth. The system may also operate in vitro with fingernail clippings. At least three spectra are obtained with one after a delay at above twenty degrees Celsius, and at least one at power levels different from the others. The spectra are used to determine and remove a mechanically induced signal from EPR spectra to determine radiation-induced spectra. The radiation induced spectra are used to determine radiation dose, the dose is compared to triage limits, and a radiological triage tag is printed for the patients.

摘要翻译： 根据放射线照射患者的装置和方法测量指甲，脚趾甲和/或牙齿的电子顺磁共振谱。 在体内，辐射诱导的光谱是从完整的指甲，脚趾甲或放置在磁体内的牙齿获得的，并且在指甲末端处的切割边缘和近端皮肤之间的钉子上具有拾取线圈，或者放置在与至少一个牙齿相邻的位置。 该系统还可以在体外用指甲剪来操作。 在二十摄氏度以上的延迟之后至少有三个光谱获得，至少有一个在功率水平不同于其他光谱。 光谱用于确定和去除EPR光谱中的机械感应信号，以确定辐射诱导光谱。 辐射诱导光谱用于确定辐射剂量，将剂量与分类限值进行比较，并为患者印刷放射性分类标签。

公开(公告)号：US20120219499A1

公开(公告)日：2012-08-30

申请号：US13508120

申请日：2010-11-05

申请人： Kimberly A. Kelly

发明人： Kimberly A. Kelly

IPC分类号： A61K51/08 ,  G01N21/64 ,  A61K49/00 ,  G01N24/10 ,  G01N29/00 ,  C07K19/00 ,  G01N33/574 ,  G01N21/76

CPC分类号： A61K51/088 ,  A61K47/64 ,  A61K49/0002 ,  A61K51/0482 ,  A61K51/065 ,  C07K7/06 ,  C07K14/00 ,  G01N33/531 ,  G01N33/574 ,  G01N2333/4724

摘要： The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric peptide ligand complexes for targeting Plectin-1, such as the multimeric peptide ligand complex having the formula (βAKTLLPTPGGS(PEG5000))4 KKKKDOTAβA-NH2, to which imaging agents and/or therapeutic agents can be conjugated.

摘要翻译： 本发明提供了用于检测和定位生物标志物Plectin-1的诊断和成像技术的组合物和方法。 本发明提供用于靶向Plectin-1的多聚体肽配体复合物，例如具有式（＆bgr; AKTLLPTPGGS（PEG5000））4 KKKKDOTA＆bgr; A-NH 2的多聚体肽配体复合物，成像剂和/或治疗剂可以 共轭。

公开(公告)号：US6031008A

公开(公告)日：2000-02-29

申请号：US894620

申请日：1997-08-22

申请人： Ann-Margret Lindqvist ,  Knut Pettersson ,  Roland Stocker ,  Christer Westerlund ,  Paul Witting

发明人： Ann-Margret Lindqvist ,  Knut Pettersson ,  Roland Stocker ,  Christer Westerlund ,  Paul Witting

IPC分类号： G01N24/10 ,  A61K31/05 ,  A01N31/08

CPC分类号： A61K31/05

摘要： Disclosed is a method for screening and/or testing in vitro of synthetic or natural compounds for antioxidant potency. Further disclosed is the use of 3,3',5,5'-tetra-tert-butyl-4,4'-bisphenol and pharmaceutical preparations thereof in restoring endothelial function.

摘要翻译： PCT No.PCT / SE97 / 00575 Sec。 371日期1997年8月22日 102（e）日期1997年8月22日PCT 1996年4月12日PCT PCT。 公开号WO97 / 38681 日期1997年10月23日公开是用于在体外筛选和/或测试合成或天然化合物的抗氧化效能的方法。 还公开了3,3'，5,5'-四叔丁基-4,4'-双酚及其药物制剂在恢复内皮功能中的用途。

公开(公告)号：US5706805A

公开(公告)日：1998-01-13

申请号：US476566

申请日：1995-06-07

申请人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu ,  Karsten Mader

发明人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu ,  Karsten Mader

IPC分类号： G01R33/28 ,  A61B5/00 ,  A61B5/055 ,  G01N24/10 ,  G01R33/465 ,  G01R33/60 ,  A61B5/14

CPC分类号： A61B5/145 ,  A61B5/055 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/465 ,  G01R33/60 ,  G01R33/281

摘要： The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively. The paramagnetic material can be used non-invasively or invasively depending on the goals of the pO2 measurement. A detecting inductive element, as part of the EPR spectrometer resonator, is adapted relative to the measurement particularities.

摘要翻译： 本发明提供了使用生理上可接受的顺磁性材料（例如印度墨水或炭黑）和电子顺磁共振（EPR）血氧测定法来测量生物系统中的氧张力的装置和方法。 印度墨水被引入生物系统并暴露于1-2GHz范围内的磁场和电磁场。 然后在生物系统中测量EPR光谱以测定氧浓度。 EPR光谱由EPR光谱仪测定，EPR光谱仪将谐振器调节到单个谐振器频率，以补偿生物系统（例如人或动物）的运动。 生物系统还可以包括其他体内组织，细胞和细胞培养物，以便非破坏性地直接测量pO2。 取决于pO2测量的目标，顺磁材料可以非侵入性或侵入性地使用。 作为EPR光谱仪谐振器的一部分的检测电感元件相对于测量特性被适配。

公开(公告)号：US5596276A

公开(公告)日：1997-01-21

申请号：US447928

申请日：1995-05-23

申请人： Kazuo Nakagawa ,  Makoto Tsuneda ,  Atsushi Nukanobu ,  Akio Nakanishi ,  Akira Furuse

发明人： Kazuo Nakagawa ,  Makoto Tsuneda ,  Atsushi Nukanobu ,  Akio Nakanishi ,  Akira Furuse

IPC分类号： G01N24/10 ,  G01R33/345 ,  G01R33/20

CPC分类号： G01R33/345

摘要： The invention provides a cavity resonator for an electron spin resonance device in which modulation coils for generating a modulation magnetic field to be applied to a sample in the cavity resonator are arranged at an exterior of the cavity resonator. The cavity resonator comprises a body being rectangular-defined by predetermined length, width and height. The body has a pair of side walls being vertical to the modulation magnetic field. The side wall respectively have at least thin portions of a thickness being nearly equal to or less than a skin depth of a skin effect appearing at the side walls. The modulation coils are arranged on the thin portions so as to have the modulation magnetic field be transmitted through the thin portions into the interior of the cavity resonator. Alternatively, it is possible that inner walls of the body are overlaid with metallic foils having at least sufficiently smaller thickness than a skin depth of a skin effect appearing at the walls.

摘要翻译： 本发明提供一种用于电子自旋共振装置的空腔谐振器，其中用于产生要施加到空腔谐振器中的样品的调制磁场的调制线圈被布置在空腔谐振器的外部。 空腔谐振器包括被预定长度，宽度和高度限定为矩形的本体。 主体具有垂直于调制磁场的一对侧壁。 侧壁分别具有至少薄的部分，其厚度几乎等于或小于出现在侧壁处的皮肤效应的皮肤深度。 调制线圈布置在薄部分上，以使调制磁场通过薄部分传输到空腔谐振器的内部。 或者，可能的是，身体的内壁被覆有金属箔，金属箔的厚度至少比出现在墙壁上的皮肤效应的皮肤深度更小。

公开(公告)号：US5387867A

公开(公告)日：1995-02-07

申请号：US97811

申请日：1993-07-26

申请人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky

发明人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky

IPC分类号： G01R33/20 ,  A61B5/055 ,  G01N24/10 ,  G01R33/60

CPC分类号： G01R33/60

摘要： An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.

摘要翻译： EPR成像器和光谱仪包括用于产生具有不被生物样品高度吸收的RF载波频率的宽带脉冲的脉冲发生系统。 脉冲发生系统包括用于频率调制载波频率脉冲的上和下啁啾转换器，并压缩频率调制脉冲以形成高能量的宽带激励脉冲。 这种机器可以形成能够对人类患者中的自由基物质具有高度敏感性的临床成像装置的基础。

公开(公告)号：US5343150A

公开(公告)日：1994-08-30

申请号：US98116

申请日：1993-07-26

申请人： Seiji Nakahata ,  Kouichi Sogabe ,  Akira Yamakawa

发明人： Seiji Nakahata ,  Kouichi Sogabe ,  Akira Yamakawa

IPC分类号： C04B35/581 ,  G01N24/10 ,  G01R33/60 ,  G01V3/00 ,  G01N25/18 ,  G01R33/20

CPC分类号： G01R33/60 ,  G01N24/10

摘要： Disclosed herein is a measuring apparatus and a measuring method which can measure a physical property value such as an oxygen content or thermal conductivity of a sample material such as an aluminum nitride sintered body with high accuracy, over the entire material in a short time. A microwave oscillation source generates microwaves. A sample material to be evaluated, such as an aluminum nitride sintered body, is placed in a cavity resonator, irradiated with microwaves (M), and subjected to a magnetic field (H) applied by electromagnets. An amount of microwaves absorbed by the object is measured by a microwave absorption measuring unit. This amount of microwave absorption is obtained from an electron spin resonance spectrum. The concentration of unpaired electrons in the object is obtained from the measured amount of microwave absorption on the basis of a known relation between an amount of microwave absorption and concentration of unpaired electrons. The concentration of unpaired electrons is converted into a physical property value such as an oxygen content or a thermal conductivity value. Such conversion processing is carried out by a computer.

摘要翻译： 本发明公开了一种能够在短时间内在整个材料上高精度地测量诸如氮化铝烧结体的样品材料的氧含量或热导率的物理性质值的测量装置和测量方法。 微波振荡源产生微波。 将待评价的样品例如氮化铝烧结体放置在空腔谐振器中，用微波（M）照射，并施加由电磁体施加的磁场（H）。 通过微波吸收测量单元测量被物体吸收的微波量。 从电子自旋共振谱获得微波吸收量。 基于微波吸收量与不成对电子浓度之间的已知关系，从测量的微波吸收量获得物体中不成对电子的浓度。 不成对电子的浓度被转换成诸如氧含量或热导率值的物理性质值。 这样的转换处理由计算机执行。

公开(公告)号：US4837163A

公开(公告)日：1989-06-06

申请号：US104463

申请日：1987-10-02

申请人： Tsuyoshi Ohnishi

发明人： Tsuyoshi Ohnishi

IPC分类号： A61B10/00 ,  A61B5/05 ,  A61D13/00 ,  G01N21/31 ,  G01N24/10 ,  G01N33/50 ,  G01N33/58 ,  G01N33/72

CPC分类号： G01N33/72 ,  G01N21/314 ,  Y10S436/805 ,  Y10S436/811

摘要： The invention provides a simple, non-invasive method of screening malignant hyperthermia using a few milliliters of blood drawn from an individual into an acid-citrate anti-coagulant. When blood preservation is not needed, the blood specimen is stored for several hours at room temperature, after which a small amount of blood is taken into a cuvette with the optical path of 0.1 mm. Then, by measuring optical densities at wavelengths of 542 and 578 nm, the susceptibility for malignant hyperthermia can be determined. When a blood specimen has to be shipped to a distant screening center, the specimen can be stored in a styroform container at 0.degree.-4.degree. C. with either wet ice or artificial coolant and delivered by an express carrier service. Upon arrival, optical measurement is done in a similar fashion.

摘要翻译： 本发明提供了一种简单的，非侵入性的方法，使用从个体将几毫升的血液吸入酸 - 柠檬酸盐抗凝血剂来筛选恶性高热。 当不需要血液保存时，将血液样本在室温下储存数小时，然后将少量血液带入具有0.1mm光程的比色杯中。 然后，通过测量波长为542和578nm的光密度，可以确定恶性高热的敏感性。 当血液样本必须运送到远处的筛选中心时，样品可以在0°-4°C的冰箱或人造冷冻液中储存，并通过快递服务进行运送。 到达时，以相似的方式进行光学测量。