公开(公告)号：US07776592B2

公开(公告)日：2010-08-17

申请号：US11469265

申请日：2006-08-31

Applicant: Angela Wandinger-Ness ,  Tamara Roitbak ,  Elsa G Romero

Inventor： Angela Wandinger-Ness ,  Tamara Roitbak ,  Elsa G Romero

IPC: C12N5/071 ,  C12N5/07 ,  A61K48/00

CPC classification number: C12N5/0687 ,  C12N2502/02 ,  C12N2502/256

Abstract: The present disclosure provides human renal stem cells. Also described are human renal stem cells isolated from the papillary region of the human kidney and methods of isolating the same. Also described are methods for culturing, characterizing, and differentiating the same, including methods for identifying human renal stem cells that are positive for Nestin and CD133, and methods for allowing the cells to differentiate into neurons.

Abstract translation: 本公开提供人肾细胞。 还描述了从人肾脏的乳头区域分离的人肾干细胞及其分离方法。 还描述了用于培养，表征和分化其的方法，包括用于鉴定对巢蛋白和CD133呈阳性的人肾干细胞的方法，以及允许细胞分化为神经元的方法。

公开(公告)号：US07717857B2

公开(公告)日：2010-05-18

申请号：US12150199

申请日：2008-04-25

Applicant: Graham Timmins ,  Vojo P. Deretic

Inventor： Graham Timmins ,  Vojo P. Deretic

IPC: A61B5/08

CPC classification number: C12Q1/04 ,  A61K51/04 ,  A61K51/0406 ,  A61K51/1206 ,  G01N33/497 ,  G01N2333/21

Abstract: The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.

Abstract translation: 本发明涉及用于检测铜绿假单胞菌感染风险的患者肺部铜绿假单胞菌感染和细菌负担的方法，特别是包括囊性纤维化（CF）患者。 本方法提供了许多试验（呼吸，血液，尿液），其易于对患者施用，其将敏感且特异性地检测肺部感染铜绿假单胞菌（粘液样和非粘液样）的存在和程度，并允许监测细菌 负载作为监测治疗的参数。

公开(公告)号：US07696696B2

公开(公告)日：2010-04-13

申请号：US11462561

申请日：2006-08-04

Applicant: Mikhail Fuks ,  Edl Schamiloglu

Inventor： Mikhail Fuks ,  Edl Schamiloglu

IPC: H01J25/50

CPC classification number: H01J25/50

Abstract: A cathode for use in a magnetron may include a plurality of longitudinally oriented emitter regions disposed around a longitudinal axis of the cathode. Each emitter region may be configured to emit electrons and adjacent emitter regions may be separated from one another by openings.

Abstract translation: 用于磁控管的阴极可以包括围绕阴极的纵向轴线设置的多个纵向取向的发射极区域。 每个发射极区域可以被配置为发射电子，并且相邻的发射极区域可以通过开口彼此分离。

公开(公告)号：US20100003167A1

公开(公告)日：2010-01-07

申请号：US12447060

申请日：2007-10-30

Applicant: Bentley Paul ,  Davenport Michael

Inventor： Bentley Paul ,  Davenport Michael

IPC: B01J19/08 ,  H01F1/42 ,  G01G9/00

CPC classification number: G01N33/54326 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22

Abstract: The present invention includes a magnetically susceptible polymer component, a method of making the same, and apparatuses and systems for mixing, separating or localizing a magnetically susceptible polymer compound in a reaction. The magnetically susceptible polymer component includes a polymer and a magnetically susceptible particle of a predetermined size, which yields a component having a much-improved magnetic reactivity due to the increase in magnetic material by mass percentage. The apparatuses and systems of the present invention employ controllable magnetic fields distributable in perpendicular directions in order to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel.

Abstract translation: 本发明包括磁敏感聚合物组分，其制备方法以及用于在反应中混合，分离或定位磁敏感性聚合物化合物的装置和系统。 磁敏感聚合物组分包括预定尺寸的聚合物和磁敏感颗粒，其由于磁性材料以质量百分比的增加而产生具有大大提高的磁反应性的组分。 本发明的装置和系统采用可分散在垂直方向上的可控磁场，以便精确地控制反应容器内的任何磁敏组件的取向，位置和相对运动。

公开(公告)号：US07633083B2

公开(公告)日：2009-12-15

申请号：US11078642

申请日：2005-03-10

Applicant: Luke F. Lester ,  Larry R. Dawson ,  Edwin A. Pease

Inventor： Luke F. Lester ,  Larry R. Dawson ,  Edwin A. Pease

IPC: H01L29/06

CPC classification number: H01L29/201 ,  H01L21/02381 ,  H01L21/02392 ,  H01L21/02395 ,  H01L21/02466 ,  H01L21/02507 ,  H01L21/0251 ,  H01L21/02546 ,  H01L21/02549 ,  H01L29/205 ,  H01L31/03046 ,  H01L31/035236

Abstract: A semiconductor device is supported by a substrate with a smaller lattice constant. A metamorphic buffer provides a transition from the smaller lattice constant of the substrate to the larger lattice constant of the semiconductor device. In one application, the semiconductor device has a lattice constant of between approximately 6.1 and 6.35 angstroms, metamorphic buffer layers include Sb (e.g., AlInSb buffer layers), and the substrate has a smaller lattice constant (e.g., Si, InP or GaAs substrates).

Abstract translation: 半导体器件由具有较小晶格常数的衬底支撑。 变质缓冲液提供从衬底的较小晶格常数到半导体器件的较大晶格常数的转变。 在一个应用中，半导体器件具有约6.1和6.35埃之间的晶格常数，变质缓冲层包括Sb（例如，AlInSb缓冲层），并且衬底具有较小的晶格常数（例如，Si，InP或GaAs衬底） 。

公开(公告)号：US20090298759A1

公开(公告)日：2009-12-03

申请号：US12083055

申请日：2006-10-26

Applicant: Terry W. Du Clos ,  Carolyn Mold

Inventor： Terry W. Du Clos ,  Carolyn Mold

IPC: A61K38/16 ,  A61K38/03 ,  A61P17/00 ,  A61P25/00 ,  C07K14/00

CPC classification number: A61K38/1709

Abstract: The present invention relates to the use of C-reactive protein, its mutants, metabolites and polypeptides and related compounds thereof for the treatment of various disease states and conditions associated with systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein, in another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition with systemic lupus erythematosus will have an outbreak is an additional aspect of the present invention.

Abstract translation: 本发明涉及C-反应蛋白，其突变体，代谢物和多肽及其相关化合物用于治疗与系统性红斑狼疮（SLE）相关的各种疾病状态和病症（包括皮肤的狼疮）（discoid））的用途， 在本发明的另一方面，诸如本文另有公开的许多其它的关节，肺和肾的系统性红斑狼疮，血液病症包括溶血性贫血和低淋巴细胞计数，淋巴结病和CNS作用，包括记忆丧失，癫痫发作和精神病， 患有疾病状态或患有系统性红斑狼疮的疾病的风险的患者可能发生爆发是本发明的另外一个方面。

公开(公告)号：US07622976B2

公开(公告)日：2009-11-24

申请号：US11774380

申请日：2007-07-06

Applicant: Lawrence T. Clark ,  John K. McIver, III

Inventor： Lawrence T. Clark ,  John K. McIver, III

IPC: H03K3/289 ,  H03K3/356

CPC classification number: H03K3/0375 ,  H03K3/3562

Abstract: The present invention includes a radiation hardened sequential circuit, such as a bistable circuit, flip-flop or other suitable design that presents substantial immunity to ionizing radiation while simultaneously maintaining a low operating voltage. In one embodiment, the circuit includes a plurality of logic elements that operate on relatively low voltage, and a master and slave latches each having storage elements that operate on a relatively high voltage.

Abstract translation: 本发明包括辐射硬化的顺序电路，例如双稳态电路，触发器或其他合适的设计，其在同时保持低工作电压的同时对电离辐射具有实质性的抗扰性。 在一个实施例中，电路包括在相对较低的电压下操作的多个逻辑元件，以及每个具有在较高电压下工作的存储元件的主锁存器和从锁存器。

公开(公告)号：US20090203588A1

公开(公告)日：2009-08-13

申请号：US11811436

申请日：2007-06-08

Applicant: Cheryl L. Willman ,  Paul Helman ,  Robert Veroff ,  Monica Mosquera-Caro ,  George S. Davidson ,  Shawn B. Martin ,  Susan R. Atlas ,  Erik Andries ,  Huining Kang ,  Jonathan J. Shuster ,  Xuefei Wang ,  Richard C. Harvey ,  David M. Haaland ,  Jeffrey W. Potter

Inventor： Cheryl L. Willman ,  Paul Helman ,  Robert Veroff ,  Monica Mosquera-Caro ,  George S. Davidson ,  Shawn B. Martin ,  Susan R. Atlas ,  Erik Andries ,  Huining Kang ,  Jonathan J. Shuster ,  Xuefei Wang ,  Richard C. Harvey ,  David M. Haaland ,  Jeffrey W. Potter

IPC: A61K38/17 ,  C12N15/12 ,  C07H21/04 ,  C07K14/47 ,  A61K31/711 ,  A61P35/02 ,  C12N5/10 ,  C12N15/85 ,  C12Q1/68 ,  G01N33/566

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136

Abstract: Genes and gene expression profiles useful for predicting outcome, risk classification, cytogenetics and/or etiology in pediatric acute lymphoblastic leukemia (ALL). OPAL1 is a novel gene associated with outcome and, along with other newly identified genes, represent a novel therapeutic targets.

Abstract translation: 基因和基因表达谱可用于预测儿科急性淋巴细胞白血病（ALL）的结局，风险分类，细胞遗传学和/或病因。 OPAL1是与结果相关的新基因，并与其他新鉴定的基因一起代表了一种新的治疗靶点。

公开(公告)号：US07541449B2

公开(公告)日：2009-06-02

申请号：US11619699

申请日：2007-01-04

Applicant: Cindy A. Sprecher ,  Walt Kisiel ,  Donald C. Foster

Inventor： Cindy A. Sprecher ,  Walt Kisiel ,  Donald C. Foster

IPC: C07H17/00

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract translation: 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段可操作地连接到第一DNA区段的表达所需的另外的DNA区段，以及含有这种DNA构建体的宿主细胞， 从宿主细胞产生蛋白质的方法。

公开(公告)号：US20080317633A1

公开(公告)日：2008-12-25

申请号：US12150607

申请日：2008-04-29

Applicant: Scott S. Sibbett ,  Gabriel P. Lopez

Inventor： Scott S. Sibbett ,  Gabriel P. Lopez

IPC: B01J19/00 ,  B32B38/10 ,  B32B38/00 ,  B32B38/18

CPC classification number: G01N33/558 ,  B01L3/5023 ,  B01L3/5027 ,  B01L2300/025 ,  B01L2300/0816 ,  B01L2300/0864 ,  B32B37/203 ,  G01N30/92 ,  Y10T156/1052

Abstract: A lateral flow device includes a porous medium layer having a two-dimensional shape in plan view defined by one or more peripheral edges wherein the two dimensional shape includes a plurality of testing regions separated from one another by spaces between portions of the one or more peripheral edges. The porous medium layer further includes a fluid-receiving region in capillary flow communication through the porous medium layer to the testing regions.

Abstract translation: 侧流装置包括具有由一个或多个外围边缘限定的平面图中的二维形状的多孔介质层，其中所述二维形状包括通过所述一个或多个周边部分之间的间隔彼此分开的多个测试区域 边缘。 多孔介质层还包括通过多孔介质层与测试区域进行毛细管流连通的流体接收区域。