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公开(公告)号：US11957102B2
公开(公告)日：2024-04-16
申请号：US17859053
申请日：2022-07-07
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Asaph Aharoni , Prashant Sonawane , Maxim Itkin
CPC classification number: A01H6/82 , C12N9/1059 , C12N15/8218 , C12N15/8243 , C12N15/8247
Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.
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公开(公告)号：US11932871B2
公开(公告)日：2024-03-19
申请号：US16490568
申请日：2018-03-02
Applicant: Yeda Research and Development Co. Ltd. , The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center
Inventor： Benjamin Geiger , Nir Friedman , Shimrit Lieber , Zelig Eshhar , Tova Waks , Anat Globerson Levin
IPC: C12N5/0783 , A61K35/17
CPC classification number: C12N5/0636 , A61K35/17 , C12N2501/21 , C12N2501/2306 , C12N2501/515 , C12N2501/58 , C12N2502/1121 , C12N2510/00
Abstract: Methods of culturing T cells are provided. Accordingly there is provided a method of culturing T cells comprising culturing T cells in the presence of a T cell stimulator, an exogenous CCL21 and an exogenous ICAM1, thereby culturing the T cells. Also provided are cell cultures, isolated T cells and uses of same.
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公开(公告)号：US20240083843A1
公开(公告)日：2024-03-14
申请号：US18272278
申请日：2021-01-14
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Einat SEGEV , Or ELIASON
IPC: C07C401/00 , C12N1/12 , C12N13/00
CPC classification number: C07C401/00 , C12N1/12 , C12N13/00
Abstract: A method of producing vitamin D is provided. The method comprising:
(a) growing E. huxleyi under controlled UV-B radiation; and (b) dehydrating the E. huxleyi.-
公开(公告)号：US20240081329A1
公开(公告)日：2024-03-14
申请号：US18224345
申请日：2023-07-20
Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Mark SAFRO , Liron KLIPCAN , Oren OSTERSETZER-BIRAN , Hagit ZER
Abstract: Provided are methods of treating water and inhibiting growth of a photosynthetic bacterium, such as cyanobacterium as well as composition-of-matters and devices for treating water. Also provided are methods of using phenylalanine structural analogues as herbicides and/or combining same with a glyphosate.
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公开(公告)号：US11907835B2
公开(公告)日：2024-02-20
申请号：US16765886
申请日：2018-11-26
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Michal Irani , Assaf Shocher
CPC classification number: G06N3/08 , G06T3/4053 , G06T5/001 , G06T2207/20016 , G06T2207/20081 , G06T2207/20084 , G06T2207/20132
Abstract: Given an input image, an image enhancement task, and no external examples available to train on, an Image-Specific Deep Network is constructed tailored to solve the task for this specific image. Since there are no external examples available to train on, the network is trained on examples extracted directly from the input image itself. The current solution solves the problem of Super-Resolution (SR), whereas the framework is more general and is not restricted to SR.
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Patent Agency Ranking
公开(公告)号：US20240042104A1
公开(公告)日：2024-02-08
申请号：US18368332
申请日：2023-09-14
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Eldad TZAHOR , Elad BASSAT
CPC classification number: A61L27/54 , C12N5/0657 , A61K38/1709 , A61P9/10 , C07K14/4725 , A61L2300/252 , C12N2501/998
Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
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公开(公告)号：US11847535B2
公开(公告)日：2023-12-19
申请号：US18300584
申请日：2023-04-14
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
IPC: G06N10/40
CPC classification number: G06N10/40
Abstract: A quantum computing system includes a first silicon nitride resonator couplable to a first alkali atom, a second silicon resonator couplable to a second alkali atom, and a plurality of lasers for trapping, cooling, and manipulating the first alkali atom and the second alkali atom. Detectors detect a presence of the trapped first alkali atom and the trapped second alkali atom, and a processor is configured to receive at least one input signal from at least one of the detectors, the input signal indicating a presence of the trapped first alkali atom and the trapped second alkali atom, and, based on the received input, control at least some of the plurality of lasers to manipulate at least one of the trapped first alkali atom and the trapped second alkali atom to thereby generate photonic qubits using the trapped first alkali atom or generate entanglement between photonic qubits transmitted to the trapped second alkali atom.
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公开(公告)号：US11846636B2
公开(公告)日：2023-12-19
申请号：US16751831
申请日：2020-01-24
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Irun R. Cohen , Eytan Domany , Noam Shental , Ittai Fattal
IPC: G01N33/53 , G01N33/564 , C12Q1/6883 , A61K31/711
CPC classification number: G01N33/564 , A61K31/711 , C12Q1/6883 , C12Q2600/158 , C12Q2600/16 , G01N33/5308 , G01N2800/104
Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.
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419.发明授权公开(公告)号：US11844827B2
公开(公告)日：2023-12-19
申请号：US17531897
申请日：2021-11-22
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yair Reisner , Noga Or-Geva , Eran Ophir , Yaki Eidelstein , Rotem Gidron Budovsky
IPC: A61K39/00 , A61K35/17 , C12N5/078 , C12N5/0783 , A61P31/00 , A61P35/04 , A61K39/395 , C07K16/28 , A61K35/12
CPC classification number: A61K39/001 , A61K35/17 , A61K39/39566 , A61P31/00 , A61P35/04 , C07K16/2896 , C12N5/0636 , C12N5/0637 , C12N5/0648 , A61K2035/122 , A61K2039/5158 , C12N2501/2307 , C12N2501/2315 , C12N2501/2321 , Y02A50/30
Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.
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公开(公告)号：US20230383254A1
公开(公告)日：2023-11-30
申请号：US18232437
申请日：2023-08-10
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yair REISNER , Noga OR-GEVA , Rotem GIDRON BUDOVSKY , Esther BACHAR-LUSTIG , Assaf LASK , Sivan KAGAN
IPC: C12N5/0783 , A61K35/17 , A61K39/00 , C12N5/00
CPC classification number: C12N5/0637 , A61K35/17 , A61K39/001 , C12N5/0087 , A61K2035/122
Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.
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