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421.发明公开公开(公告)号：US20230366885A1
公开(公告)日：2023-11-16
申请号：US18350066
申请日：2023-07-11
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David MARGULIES , Leila Motiei , Naama Lahav , Pragati Prasad
IPC: G01N33/58 , G01N33/574
CPC classification number: G01N33/582 , G01N33/574
Abstract: The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.
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公开(公告)号：US11786640B2
公开(公告)日：2023-10-17
申请号：US16746878
申请日：2020-01-19
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Eldad Tzahor , Elad Bassat
CPC classification number: A61L27/54 , A61K38/1709 , A61P9/10 , C07K14/4725 , C12N5/0657 , A61L2300/252 , C12N2501/998
Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.
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公开(公告)号：US20230321235A1
公开(公告)日：2023-10-12
申请号：US18020441
申请日：2021-08-11
Applicant: Yeda Research and Development Co. Ltd. , Ichilov Tech Ltd.
Inventor： Yair REISNER , Anat GLOBERSON LEVIN , Esther BACHAR-LUSTIG , Assaf LASK , Bar NATHANSOHN-LEVI , Tova WAKS , Galit HORN , Zelig ESHHAR
IPC: A61P35/00 , C12N5/0783 , A61K39/00
CPC classification number: A61K39/4611 , A61K39/4631 , A61P35/00 , C12N5/0636 , A61K2239/22 , C12N2510/00
Abstract: A method of generating a population of genetically modified veto cells is disclosed. The method comprising: (a) providing a population of cells comprising T cells, the T cells comprising at least 40% memory CD8+ T cells; (b) culturing the population of cells comprising T cells with an antigen or antigens under conditions which allow enrichment of tolerance-inducing antigen-specific cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being depleted of graft versus host (GVH) reactivity; and (c) transducing the cells with a polynucleotide encoding a heterologous cell surface receptor comprising a T cell receptor signaling module, thereby generating the population of genetically modified veto cells.
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公开(公告)号：US20230316120A1
公开(公告)日：2023-10-05
申请号：US17999934
申请日：2021-06-03
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： Roee OZERI , Tom MANOVITZ , Yotam SHAPIRA , Nitzan AKERMAN , Adiel STERN
Abstract: Method and apparatus for quantum simulation, based on a linear chain of ions. A gradient field is imposed to break the symmetry of the ion chain, and bichromatic driving fields are applied to bridge the energy gaps induced by the gradient field and thereby establish resonance couplings among the ions according to their relative positions in the gradient field. The combination of the gradient field and the bichromatic driving fields implement excitation hopping to simulate a variety of topologies according to higher¬dimensional Hamiltonians and boundary conditions, including ring, torus, Mobius strip configurations, as well as topologies with periodic boundary conditions. In particular synthetic gauge fields allow simulation of magnetic flux.
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公开(公告)号：US20230313173A1
公开(公告)日：2023-10-05
申请号：US17787977
申请日：2020-12-22
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yosef SHAUL , Nina REUVEN
IPC: C12N15/10 , C12N9/22 , C12N15/11 , C12N5/071 , C12N15/113
CPC classification number: C12N15/102 , C12N9/22 , C12N15/11 , C12N5/0686 , C12N15/113 , C12N2310/20 , C12N2510/00 , C12N2310/14
Abstract: Kits and methods for selecting a cell harboring a genome-editing event at a target sequence of interest are disclosed. One such kit comprises:
(i) a first DNA editing agent for specifically introducing a mutation into a first gene so as to generate a first selection marker which imparts resistance to a selection agent, wherein the target sequence of interest the said first gene are distinct; and
(ii) the selection agent; and/or
(iii) a second DNA editing agent for specifically introducing a mutation into the first gene, wherein the mutation disrupts selection marker activity of the first selection marker.-
Patent Agency Ranking
公开(公告)号：US20230301915A1
公开(公告)日：2023-09-28
申请号：US18202981
申请日：2023-05-29
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Jacob KLEIN , Ronit GOLDBERG , Weifeng LIN
CPC classification number: A61K9/1273 , A61P19/02 , A61K9/0019
Abstract: A liposome for use in delivering a therapeutically active agent to a subject in need thereof is disclosed herein. The liposome comprises:
a) at least one bilayer-forming lipid;
b) a polymeric compound having the general formula I:
wherein m, n, L, X, Y, and Z are as defined herein; and
c) a therapeutically active agent, incorporated in the liposome and/or on a surface of the liposome.-
公开(公告)号：US11764003B2
公开(公告)日：2023-09-19
申请号：US16896266
申请日：2020-06-09
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Milko E. Van Der Boom , Michal Lahav , Neta Elool Dov , Ofir Eisenberg , Yadid Algavi
CPC classification number: H01G11/24 , H01G11/04 , H01G11/36 , H01G11/46 , H01G11/48 , H01G11/54 , C08G61/126 , H02J2207/50
Abstract: A hybrid supercapacitor where the charging state is indicated by color is demonstrated. The device comprises a molecular network that functions as both the battery-type electrode and the charge indicator. Related batteries, electrodes and devices, their processes of preparation and methods of use are provided as well.
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428.发明授权公开(公告)号：US11746006B2
公开(公告)日：2023-09-05
申请号：US17416772
申请日：2019-12-30
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： David Milstein , You-Quan Zou , Aviel Anaby
CPC classification number: C01B3/0015 , B01J31/189 , B01J31/20 , B01J31/2404 , B01J2231/763 , B01J2531/821
Abstract: This invention provides a reversible hydrogen loading and discharging system and a reversible method for loading and discharging hydrogen. The system and the methods of this invention comprise ethylene glycol as a liquid organic hydrogen carrier and at least one transition metal. By reacting ethylene glycol with at least one transition metal; at least one hydrogen molecule and at least one oligoester of ethylene glycol are formed (hydrogen releasing)⋅, and by reacting at least one oligoester of ethylene glycol with at least one transition metal and at least one hydrogen molecule, at least one ethylene glycol is formed (hydrogen loading).
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公开(公告)号：US20230263884A1
公开(公告)日：2023-08-24
申请号：US18122169
申请日：2023-03-16
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Gideon SCHREIBER , Jiri ZAHRADNIK , Yinon RUDICH
IPC: A61K39/215 , C07K14/005
CPC classification number: A61K39/215 , C07K14/005 , A61K38/00
Abstract: A polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD) is disclosed, wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501, wherein the polypeptide binds soluble, monomeric angiotensin-converting enzyme 2 (ACE2) receptor. Uses thereof are further disclosed.
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公开(公告)号：US20230248779A1
公开(公告)日：2023-08-10
申请号：US18137455
申请日：2023-04-21
Applicant: Kadimastem Ltd. , Yeda Research and Development Co. Ltd.
Inventor： Kfir MOLAKANDOV , Neta LAVON , Avital BECK , Michel REVEL , Ofer ELHANANI , Yoav SOEN , Michael WALKER , Arye HASSON
CPC classification number: A61K35/39 , C12N5/0676 , A61P5/50 , A61P3/10 , C12N2506/45 , C12N2500/38 , C12N2500/34 , C12N2506/02 , C12N2501/599 , C12N2500/25
Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.
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