公开(公告)号：US20230235464A1

公开(公告)日：2023-07-27

申请号：US18002661

申请日：2021-06-17

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny NEUMANN ,  Yehonatan KAUFMAN

IPC: C25B3/07 ,  C25B3/23 ,  C25B15/027 ,  C25B11/065 ,  C25B11/061 ,  C25B11/077 ,  C25B11/081

CPC classification number: C25B3/07 ,  C25B3/23 ,  C25B15/027 ,  C25B11/065 ,  C25B11/061 ,  C25B11/077 ,  C25B11/081

Abstract: This invention is directed to a method of oxygenating hydrocarbons with molecular oxygen, O2, as oxidant under electrochemical reducing conditions, using polyoxometalate compounds containing copper such as Q10[Cu4(H2O)2(B-α-PW9O34)2] or Q13{[Cu(H2O)]3[(A-α-PW9O34)2(NO3)−]} or solvates thereof as catalysts, wherein Q are each independently selected from alkali metal cations, alkaline earth metal cations, transition metal cations, NH4+, H+ or any combination thereof.

公开(公告)号：US11680263B2

公开(公告)日：2023-06-20

申请号：US17227483

申请日：2021-04-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon Chen ,  Orna Issler

IPC: C12N15/113 ,  C12Q1/6883 ,  C12N15/11 ,  C07H21/02

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12Q1/6883 ,  C12N2310/141 ,  C12N2320/30 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US11643464B2

公开(公告)日：2023-05-09

申请号：US16728587

申请日：2019-12-27

Applicant: Yeda Research and Development Co. Ltd

Inventor： Michal Eisenbach-Schwartz ,  Kuti Baruch ,  Neta Rosenzweig

IPC: C07K16/28 ,  A61K39/395 ,  A61P27/02 ,  A61K45/06 ,  A61K31/404 ,  A61K31/7068 ,  A61K31/4155 ,  A61K33/36 ,  A61K39/00

CPC classification number: C07K16/2818 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/7068 ,  A61K33/36 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  C07K16/2803 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  A61K2039/572 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  A61K33/36 ,  A61K2300/00 ,  A61K31/404 ,  A61K2300/00 ,  A61K31/4155 ,  A61K2300/00 ,  A61K31/7068 ,  A61K2300/00

Abstract: The present specification discloses a pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS. The pharmaceutical composition is administered by a dosage regimen comprising at least one course of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

公开(公告)号：US20230132385A9

公开(公告)日：2023-04-27

申请号：US17278261

申请日：2019-09-20

Applicant: Tikcro Technologies Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Ami Navon ,  Aviv Boim ,  Ariel Stanhill ,  Leehee Weinberger ,  Yuval Avnir

IPC: C07K16/28

Abstract: Disclosed herein are anti-CTLA-4 antibodies possessing superior binding and biological activities relative to ipibmumab and tremelimumab, pharmaceutical compositions comprising such. Also provided herein are therapeutic and diagnostic applications of such anti-CTLA-4 antibodies.

公开(公告)号：US20230076246A1

公开(公告)日：2023-03-09

申请号：US17800245

申请日：2020-02-17

Applicant: Yeda Research and Development Co. Ltd. ,  Mor Research Applications Ltd.

Inventor： Eran SEGAL ,  Smadar SHILO ,  Yotam AMAR

IPC: A61B5/00 ,  G06N3/08 ,  A61B5/145

Abstract: A method of predicting an analyte level comprises receiving a time-ordered series of levels of the analyte, monitored over a time-period; feeding a trained neural network procedure with the monitored levels; and displaying, based on an output received from the procedure, a predicted level of the analyte in a future time. The procedure can comprise a plurality of layers, wherein for at least one pair of layers, a number of inter-layer connections within the pair is higher for later monitored levels than for earlier monitored levels.

公开(公告)号：US20230072222A1

公开(公告)日：2023-03-09

申请号：US17583378

申请日：2022-01-25

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Helena SHOMAR MONGES ,  Rotem SOREK ,  Lianet NODA GARCIA ,  Arthur MACHLENKIN ,  David SPERANDIO

IPC: C07H19/20 ,  C07H19/10 ,  A61P31/14

Abstract: Disclosed herein are 3, 4-didehydro- and 3′-deoxy-3, 4-didehydro-compounds and pharmaceutical compositions thereof. Methods of use of these pharmaceutical compositions include those for treating diseases including virus-induced diseases, cancer, autoimmune diseases, immune disorders, and bacterial-associated diseases or infections, or combinations thereof. Examples of viral-induced diseases include viral infections by RNA or DNA viruses, for example SAR-CoV-2, EBV, BKV, JCV and HCMV.

公开(公告)号：US11600264B2

公开(公告)日：2023-03-07

申请号：US16767110

申请日：2018-11-26

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Elisha Moses ,  Tirza Biron ,  Dominik Freche ,  Daniel Baum ,  Nadav Matalon ,  Netanel Ehrmann ,  Eyal Weinreb

IPC: G10L15/22 ,  G10L15/18 ,  G10L15/02 ,  G10L15/05

Abstract: A prosodic speech recognition engine configured to identify prosodic features and patterns in a speech continuum for the extraction of linguistic content including para-syntactic content, discourse function, information structure, meaning, and speaker sentiment.

公开(公告)号：US11593638B2

公开(公告)日：2023-02-28

申请号：US16412675

申请日：2019-05-15

Applicant: New York University ,  Yeda Research And Development Co. Ltd.

Inventor： Itay Kezurer ,  Yoram Eshel ,  Achiau Ludomirsky ,  Yaron Lipman

IPC: G06N3/08 ,  G06T7/00 ,  A61B8/00 ,  G06T3/20 ,  G06T11/00 ,  G16H30/40 ,  A61B5/00 ,  A61B8/13 ,  G09B23/28 ,  G06T3/60

Abstract: A downloadable navigator for a mobile ultrasound unit having an ultrasound probe, implemented on a portable computing device. The navigator includes a trained orientation neural network to receive a non-canonical image of a body part from the mobile ultrasound unit and to generate a transformation associated with the non-canonical image, the transformation transforming from a position and rotation associated with a canonical image to a position and rotation associated with the non-canonical image; and a result converter to convert the transformation into orientation instructions for a user of the probe and to provide and display the orientation instructions to the user to change the position and rotation of the probe.

公开(公告)号：US20220392571A1

公开(公告)日：2022-12-08

申请号：US17884594

申请日：2022-08-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Amos TANAY ,  Amir GILADI ,  Merav COHEN

IPC: G16B25/10

Abstract: A method of determining cell members of a cell cluster in a tissue of interest is disclosed. The cell members physically interact with one another in the cell cluster. Computer software products capable of carrying out the method are also disclosed.

公开(公告)号：US11491301B2

公开(公告)日：2022-11-08

申请号：US16545007

申请日：2019-08-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anat Arzi ,  Lee Sela ,  Anton Plotkin ,  Aharon Weissbrod ,  Noam Sobel

IPC: A61M16/00 ,  A61M21/02 ,  A61M16/10 ,  A61M15/08 ,  A61M21/00

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.