公开(公告)号：US5256771A

公开(公告)日：1993-10-26

申请号：US504161

申请日：1990-04-03

申请人： Grace C. Tsay ,  Gary Jesmok

发明人： Grace C. Tsay ,  Gary Jesmok

IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K16/00 ,  C07K3/12 ,  C07K15/06

CPC分类号： C07K16/00 ,  A61K38/00 ,  Y10S424/806 ,  Y10S530/863

摘要： Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM immunoglobulin concentrates retain specific antigen binding properties and activate complement specific antigen binding properties and activate complement when bound to antigen. Preferred product includes at least 20% by weight IgM in an IgM/IgG antibody mixture. Heating is done at a temperature within the range of about 40.degree. C. to 62 .degree. C., preferably about 45.degree. to 55.degree. C., in a solution having an acid pH (preferably 4.0 to 5.0) for at least about 10 minutes.

公开(公告)号：US5250663A

公开(公告)日：1993-10-05

申请号：US848439

申请日：1992-03-09

申请人： Robert A. Tenold

发明人： Robert A. Tenold

IPC分类号： A61K38/00 ,  C07K14/765 ,  C07K3/24 ,  C07K15/06

CPC分类号： C07K14/765 ,  A61K38/00

摘要： A composition is disclosed which comprises a solution of human serum albumin essentially free of chemicals used in processing. The preparation is also essentially free of metals such as aluminum. The composition is 100% pure by cellulose acetate electrophoresis and is essentially monomeric when tested by high pressure liquid chromatography. The turbidity is less than 5 N.T.U. (National Turbidity Units). This preparation has a substantially longer shelf life and remains biologically active longer than products currently available. The novelty of this product is also such that it does not leach metallic substances such as aluminum from its closure. Novel applications of process methodology are taught in the preparation of this composition and a novel preparation results from essentially non hemoglobin containing albumin sources such as Source Plasma (Human).

摘要翻译： 公开了一种组合物，其包含基本上不含用于加工的化学品的人血清白蛋白溶液。 该制剂也基本上不含金属如铝。 通过醋酸纤维素电泳，组合物为100％纯，当通过高压液相色谱测试时，其组成基本上是单体的。 浊度小于5 N.T.U. （国家浊度单位）。 该制剂具有显着更长的保存期限，并且比目前可获得的产品具有更长的生物活性。 该产品的新颖性也使得它不会从其封闭物中浸出金属物质如铝。 在制备该组合物时教导了方法的新颖应用，并且从基本上不含血红蛋白的白蛋白来源（如源等离子体（Human））得到新的制备。

公开(公告)号：US5248596A

公开(公告)日：1993-09-28

申请号：US844354

申请日：1992-03-02

申请人： Pamela C. Esmon ,  Emma Yee ,  Robert E. Jordan ,  Richard M. Nelson

发明人： Pamela C. Esmon ,  Emma Yee ,  Robert E. Jordan ,  Richard M. Nelson

IPC分类号： C07K16/38

CPC分类号： C07K16/38 ,  Y10S435/962 ,  Y10S435/967

摘要： Indirect method of detecting elastase-modified or cleaved, antithrombin (ATx) in the presence of intact antithrombin (AT-III). The inventive method includes a modified ELISA using a detergent to alter the intact AT-III. Cleaved AT-III is generated in human plasma, then an ELISA is performed in the presence of a detergent.

摘要翻译： 在完整抗凝血酶（AT-III）存在下检测弹性蛋白酶修饰或切割的抗凝血酶（ATx）的间接方法。 本发明的方法包括使用洗涤剂改变完整AT-III的修饰ELISA。 在人血浆中产生切割的AT-III，然后在洗涤剂存在下进行ELISA。

公开(公告)号：US5243012A

公开(公告)日：1993-09-07

申请号：US896702

申请日：1992-06-10

申请人： Douglas A. Wicks ,  Philip E. Yeske

发明人： Douglas A. Wicks ,  Philip E. Yeske

IPC分类号： C09D175/02 ,  C08G18/38 ,  C09D175/00

CPC分类号： C08G18/3821

摘要： The present invention relates to a coating composition for the preparation of a polyurea coating which containsa) a polyisocyanate component,b) at least one compound corresponding to the formula ##STR1## wherein X represents an organic group which has a valency of n and is inert towards isocyanate groups at a temperature of 100.degree. C. or less,R.sup.1 and R.sup.2 may be identical or different and represent organic groups which are inert towards isocyanate groups at a temperature of 100.degree. C. or less,R.sup.3 and R.sup.4 may be identical or different and represent hydrogen or organic groups which are inert towards isocyanate groups at a temperature of 100.degree. C. or less andn represents an integer with a value of at least 2, andc) 0.001 to 5 weight percent, based on the weight of components a) and b), of a tin(IV) compound which is a catalyst for the reaction between isocyanate groups and hydroxyl groups.

公开(公告)号：US5236994A

公开(公告)日：1993-08-17

申请号：US676678

申请日：1991-03-28

申请人： Peter H. Markusch ,  William Cibulas ,  Robin E. Tirpak

发明人： Peter H. Markusch ,  William Cibulas ,  Robin E. Tirpak

IPC分类号： C04B41/48 ,  C04B41/63 ,  C08G18/28 ,  C08G18/70 ,  C08G18/80

CPC分类号： C04B41/009 ,  C04B41/4884 ,  C04B41/63 ,  C08G18/283 ,  C08G18/706 ,  C08G18/8038 ,  C08G18/8041 ,  Y10T428/31551 ,  Y10T428/31598

摘要： The present invention is directed to a process for sealing and/or priming concrete by applying to concrete an aqueous polyisocyanate dispersion which has an isocyanate content of at least 0.5% by weight, based on the weight of the polyisocyanate, and is prepared bya) dispersing in water a polyisocyanate which has an isocyanate content of at least 12% by weight andb) optionally reacting the dispersed polyisocyanate withi) a primary or secondary monoamine containing at least one hydroxyl group in an amount sufficient to provide an equivalent ratio of amino groups to isocyanate groups of 0:1.0 to 0.7:1.0 and/orii) a polyamine having primary and/or secondary amino groups and a molecular weight of 400 or less in an amount sufficient to provide an equivalent ratio of amino groups to isocyanate groups of 0:1.0 to 0.4:1.0,provided that when components i) and ii) are both reacted with the dispersed polyisocyanate, component i) is mixed with the dispersed polyisocyanate either before or during the mixing of component ii) and the equivalent ratio of amino groups from both components i) and ii) does not exceed 0.95:1.0.The present invention is also directed to the primed and sealed concrete obtained in accordance with this process.

公开(公告)号：US5236498A

公开(公告)日：1993-08-17

申请号：US799453

申请日：1991-11-26

申请人： Charles G. Zaloum ,  Michael J. Greene

发明人： Charles G. Zaloum ,  Michael J. Greene

IPC分类号： C08K5/3447 ,  C08K5/3442 ,  C09B67/22 ,  C09B67/52 ,  C09D5/38 ,  C09D11/02

CPC分类号： C09B67/0027 ,  C09B67/0036

摘要： This invention relates to quinacridone solid solutions containing(a) 95% to 5% by weight of 2,9-dimethoxyquinacridone, and (b) 5% to 95% by weight of 2,9-dichloroquinacridone, characterized by X-ray diffraction patterns that are different from the sum of the X-ray diffraction patterns of the individual quinacridone components. The invention further relates to the use of such solid solutions for pigmentation of fibers, plastics, coatings, printing inks, and the like.

公开(公告)号：US5232988A

公开(公告)日：1993-08-03

申请号：US841130

申请日：1992-02-25

申请人： Lanny D. Venham ,  Marianne M. Salek ,  Terry A. Potter

发明人： Lanny D. Venham ,  Marianne M. Salek ,  Terry A. Potter

IPC分类号： C08G18/42 ,  C08G18/62 ,  C08G18/79 ,  C08G18/80 ,  C09D175/00 ,  C09D175/04

CPC分类号： C08G18/42 ,  C08G18/6229 ,  C08G18/6254 ,  C08G18/792 ,  C08G18/8061 ,  C08G18/8077 ,  Y10T428/31547

摘要： The present invention relates to a blocked polyisocyanate which is based on the reaction product of a polyisocyanate with a reversible, monofunctional blocking agent for isocyanate groups, wherein the polyisocyanate is prepared by trimerizing 5 to 85% of the isocyanate groups of a cyclic organic diisocyanate having (cyclo)aliphatically bound isocyanate groups and containsi) an isocyanurate group-containing polyisocyanate andii) at least 5% by weight, based on the weight of the polyisocyanate, of unreacted diisocyanate.The present invention also relates to a one-component coating composition containing this blocked polyisocyanate and a polyhydroxyl polyacrylate and/or a polyhydroxyl polyester.Finally, the present invention relates to substrates coated with this coating composition.

公开(公告)号：US5229296A

公开(公告)日：1993-07-20

申请号：US816339

申请日：1991-12-30

申请人： Elva Kurchacova ,  Meitak T. Yip

发明人： Elva Kurchacova ,  Meitak T. Yip

IPC分类号： C08L101/08 ,  C08L101/00 ,  C12Q1/26 ,  G01N33/52 ,  G01N33/72

CPC分类号： G01N33/728 ,  C12Q1/26 ,  G01N33/721 ,  Y10T436/146666 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： Disclosed is a method for separating biological substances, particularly hemoglobin or bilirubin, from blood plasma or serum which involves contacting the plasma or serum with a water insoluble complex of a polymer containing multiple pendant carboxyl groups and copper.

公开(公告)号：US5220035A

公开(公告)日：1993-06-15

申请号：US687061

申请日：1991-04-18

申请人： James P. Albarella

发明人： James P. Albarella

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/52

CPC分类号： C12Q1/26 ,  C12Q1/00 ,  C12Q1/54 ,  G01N33/526

摘要： Test compositions, indicators, and test device are provided which are capable of generating different hues at different analyte concentrations. The compositions are capable of generating a yellow hue in situ. Visual tests for clinically important analytes, such as glucose, are determined by use of two independent catalytic systems which are reactive with reduced nicotinamide adenin dinucleotide to produce a range of hues; the particular hue produced depending on the concentration of the analyte. The invention provides a test device for the determination of analyte, e.g. glucose, in body fluid which exhibits a RAINBOW of hues, the particular final hue produced depending on the analyte concentration.

摘要翻译： 提供了能够在不同分析物浓度下产生不同色调的测试组合物，指示剂和测试装置。 组合物能够原位产生黄色色调。 通过使用与还原型烟酰胺腺嘌呤二核苷酸反应产生一系列色调的两个独立的催化系统来确定临床上重要的分析物（例如葡萄糖）的目测。 根据分析物的浓度产生特定色调。 本发明提供了一种用于测定分析物的测试装置， 葡萄糖在体液中呈现出色调的RAINBOW，根据分析物浓度产生特定的最终色调。

公开(公告)号：US5214078A

公开(公告)日：1993-05-25

申请号：US891875

申请日：1992-06-03

申请人： Douglas G. Powell ,  Charles E. Lundy

发明人： Douglas G. Powell ,  Charles E. Lundy

IPC分类号： C08K5/1545 ,  C08K5/372 ,  C08L69/00

CPC分类号： C08K5/1545 ,  C08K5/372 ,  C08L69/00

摘要： A thermoplastic polycarbonate molding composition comprising a polycarbonate resin and a stabilizing agent is disclosed. Containing (i) a polyether polyol and (ii) an aromatic disulfide, the agent imparts to the composition improved resistance to gamma-radiation-induced color change. Articles molded from the composition of the invention are suitable for the preparation of gamma-radiation sterilizable medical equipment.

摘要翻译： 公开了一种包含聚碳酸酯树脂和稳定剂的热塑性聚碳酸酯模塑组合物。 包含（i）聚醚多元醇和（ii）芳族二硫化物，该试剂赋予组合物提高的对γ-辐射引起的颜色变化的耐性。 由本发明组合物成型的制品适用于γ-辐射灭菌医疗设备的制备。