公开(公告)号：US20150184230A1

公开(公告)日：2015-07-02

申请号：US14052434

申请日：2013-10-11

Applicant: Osaka Prefecture University Public Corporation ,  FUSO Pharmaceutical Industries, Ltd.

Inventor： Shinji YAMASAKI ,  Worada SAMOSORUNSUK ,  Masahiro ASAKURA

IPC: C12Q1/68 ,  C07K16/12

CPC classification number: C12Q1/689 ,  C07K16/1203 ,  C07K16/121 ,  C07K2317/76 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/56922 ,  G01N2333/205 ,  Y02A50/451

Abstract: An objective of the present invention is to provide the cytolethal distending toxin (CDT) of C. hyointestinalis and polynucleotides encoding it, and novel methods for detection of C. hyointestinalis using the cdt genes. The present inventors focused on the cytolethal distending toxin (CDT) of Campylobacter bacteria, and detected the cdt genes of a Campylobacter-like bacterium isolated from an enteritis patient in Thailand. The present inventors discovered a bacterial strain whose cdtB gene was amplified by common primers in C. jejuni, C. coli, and C. fetus, but not by multiplex PCR that can specifically detect the cdtA, cdtB, and cdtC genes of the three bacterial species. The bacterial strain was identified as C. hyointestinalis by 16S rRNA gene analysis. Furthermore, the entire nucleotide sequence of the cdt genes was determined by genome walking upstream and downstream of the cdtB gene.

Abstract translation: 本发明的目的是提供嗜肝绞胃细胞的细胞致死性扩张毒素（CDT）和编码它的多核苷酸，以及使用cdt基因检测猪肝炎的新方法。 本发明人专注于弯曲杆菌细菌的细胞致死性扩张毒素（CDT），并检测了从泰国肠炎患者分离的弯曲杆菌样细菌的cdt基因。 本发明人发现了一种细菌菌株，其cdtB基因在空肠弯曲杆菌，大肠杆菌和C.胎儿中被普通引物扩增，但不能通过可以特异性检测三种细菌的cdtA，cdtB和cdtC基因的多重PCR扩增 种类。 通过16S rRNA基因分析将细菌菌株鉴定为嗜肝菌。 此外，cdt基因的全部核苷酸序列通过cdtB基因的上游和下游的基因组走向来测定。

公开(公告)号：US08940921B2

公开(公告)日：2015-01-27

申请号：US13254546

申请日：2010-03-14

Applicant: Yasuaki Maeda ,  Hiroshi Bandow ,  Norimichi Takenaka ,  Yasuhiro Sadanaga ,  Kenji Okitsu

Inventor： Yasuaki Maeda ,  Hiroshi Bandow ,  Norimichi Takenaka ,  Yasuhiro Sadanaga ,  Kenji Okitsu

IPC: C11C3/10 ,  C10L1/02 ,  C10L1/08 ,  C11C3/00 ,  C11B13/00

CPC classification number: C11C3/003 ,  C10G2300/1014 ,  C10G2300/44 ,  C10L1/026 ,  C11B13/00 ,  Y02E50/13 ,  Y02P30/20 ,  Y02W30/74

Abstract: [Problem] There are provided a method for production of a fatty acid alkyl ester and a system therefor, in which a high yield of the fatty acid alkyl ester is achieved even without using any special equipment and separation of a fatty acid alkyl ester phase from a glycerin phase can be carried out within an extremely short period of time.[Means to solve] The method for producing a fatty acid alkyl ester of the present invention comprises subjecting a starting oil to an ester exchange reaction with a lower alkyl alcohol in the presence of a catalyst to generate the fatty acid alkyl ester, wherein the ester exchange reaction step is carried out in a homogeneous phase system by adding an organic solvent selected from acetone, isopropanol and a mixture thereof to a reaction system.

Abstract translation: [问题]提供了一种生产脂肪酸烷基酯及其制备方法，其中即使不使用任何特殊设备也可获得高产率的脂肪酸烷基酯，并且将脂肪酸烷基酯相从 甘油相可以在极短的时间内进行。 [解决方案]本发明的脂肪酸烷基酯的制造方法包括在催化剂存在下使起始油与低级烷基醇进行酯交换反应，生成脂肪酸烷基酯，其中酯 通过将选自丙酮，异丙醇及其混合物的有机溶剂加入到反应体系中，在均相系统中进行交换反应步骤。

公开(公告)号：US08815244B2

公开(公告)日：2014-08-26

申请号：US13210512

申请日：2011-08-16

Applicant: Yasuhiro Tsukamoto

Inventor： Yasuhiro Tsukamoto

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/10 ,  A61K39/00

CPC classification number: C07K16/00 ,  A61K2039/505 ,  C07K16/10 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2851 ,  C07K2317/23 ,  C07K2317/76

Abstract: Disclosed is an antibody produced using an ostrich. Also disclosed is a method for producing the antibody. By using an ostrich, it becomes possible to produce antibodies (particularly antibodies for medical use), which have been hardly produced by using the mammals such as the mouse and the rat, homogeneously in a single body, in large quantities and in a simple manner. The method can overcome a disadvantage of lot-to-lot variation which may occur in the production of polyclonal antibodies using other animals.

Abstract translation: 公开了使用鸵鸟产生的抗体。 还公开了制备抗体的方法。 通过使用鸵鸟，可以大量生产抗体（特别是医疗用抗体），这些抗体几乎不能通过在单体中同时使用小鼠和大鼠等哺乳动物而均匀地产生 。 该方法可以克服在使用其他动物的多克隆抗体的产生中可能发生的批次间变异的缺点。

公开(公告)号：US20140154585A1

公开(公告)日：2014-06-05

申请号：US14234118

申请日：2012-07-25

Applicant: Akitoshi Hayashi ,  Masahiro Tatsumisago

Inventor： Akitoshi Hayashi ,  Masahiro Tatsumisago

IPC: H01M10/39

CPC classification number: H01M10/0562 ,  H01M4/5815 ,  H01M10/054 ,  H01M10/3918 ,  H01M2220/20 ,  H01M2220/30 ,  H01M2300/0068

Abstract: An all-solid-state secondary cell comprising at least a positive electrode, a negative electrode and a solid electrolyte layer which is positioned between the positive electrode and the negative electrode, wherein: the positive electrode contains an positive electrode active material consisting of a Na2Sx (x=1 to 8) and the solid electrolyte layer contains an ion conductive glass ceramics represented by a formula (I): Na2S-MxSy wherein M is selected from P, Si, Ge, B and Al; x and y each is an integer giving a stoichiometric ratio depending upon the type of M; and Na2S is contained in an amount of more than 67 mole % and less than 80 mole %.

Abstract translation: 一种全固态二次电池，其至少包含位于所述正极和负极之间的正极，负极和固体电解质层，其中：所述正极含有由Na 2 S x （x = 1〜8），固体电解质层含有由式（I）表示的离子导电性玻璃陶瓷：其中M选自P，Si，Ge，B和Al的Na 2 S-M x S y; x和y各自是根据M的类型给出化学计量比的整数; 并且Na 2 S的含量大于67摩尔％且小于80摩尔％。

公开(公告)号：US08696833B2

公开(公告)日：2014-04-15

申请号：US11886183

申请日：2006-03-24

Applicant: Takayuki Takasugi ,  Yasuyuki Kaneno

Inventor： Takayuki Takasugi ,  Yasuyuki Kaneno

IPC: C22C19/03 ,  C22F1/10

CPC classification number: C22F1/00 ,  C22C19/03 ,  C22F1/10 ,  C30B11/00 ,  C30B29/52

Abstract: An intermetallic compound having excellent mechanical properties at high temperatures is provided. An intermetallic compound of the present invention contains greater than 5 at % and not greater than 13 at % of Al, not less than 9.5 at % and less than 17.5 at % of V, not less than 0 at % and not greater than 3.5 at % of Ti, not less than 0 weight ppm and not greater than 1000 weight ppm of B, and the remaining portion consisting of Ni and inevitable impurities, and having a dual multi-phase microstructure comprising a primary L12 phase and an (L12+D022) eutectoid microstructure.

Abstract translation: 提供了在高温下具有优异的机械性能的金属间化合物。 本发明的金属间化合物含有大于5at％且不大于13at％的Al，不小于9.5at％且小于17.5at％V，不小于0at％且不大于3.5 at ％的Ti，不小于0重量ppm和不大于1000重量ppm的B，其余部分由Ni和不可避免的杂质组成，并且具有包括主L12相和（L12 + D022）的双重多相微结构 ）共析显微结构。

公开(公告)号：US20140086492A1

公开(公告)日：2014-03-27

申请号：US14119775

申请日：2012-05-15

Applicant: Masakazu Iwamura ,  Koichi Kise

Inventor： Masakazu Iwamura ,  Koichi Kise

IPC: G06K9/62 ,  G06F17/30

CPC classification number: G06K9/62 ,  G06F16/50 ,  G06F16/56

Abstract: The present application relates to a method whereby a plurality of characteristic vectors which are extracted from image data are logged in a database together with the image data for approximate nearest neighbor searching, and has as an objective reducing computation time and memory use. L groups of K hash tables are generated, and each characteristic vector is respectively logged with each hash table. With one group as a copy destination, another group as a copy source, and each respective division by combination of logging bin of the K hash tables of each group as a bucket: 1) a given characteristic vector is focused on; 2) another characteristic vector which is logged in the same bucket in the copy source as the characteristic vector is identified; 3) a characteristic vector is selected in which a number of groups in which the other characteristic vector is logged in the same bucket as the characteristic vector which is focused on is greater than or equal to a prescribed threshold; and 4) when the characteristic vector which is selected in 3) is not logged in each bin of the copy destination in which the characteristic vector being focused on is logged, the characteristic vector is logged in each bin. After focusing on a prescribed number of characteristic vectors and executing 1)-4) foregoing for each characteristic vector, the copy source hash tables are deleted.

Abstract translation: 本申请涉及一种方法，其中从图像数据中提取的多个特征向量与用于近似最近邻搜索的图像数据一起记录在数据库中，并且具有减少计算时间和存储器使用的目的。 生成L组K个哈希表，并且每个特征向量分别与每个散列表一起记录。 将一组作为复制目的地，另一组作为复制源，并将每个组的K个哈希表的日志文件夹的组合分别作为一个桶：1）给定的特征向量集中在; 2）识别特征向量时在复制源中记录在同一桶中的另一个特征向量; 3）选择特征向量，其中与聚焦的特征向量相同的桶中记录另一特征向量的组数大于或等于规定阈值; 和4）当记录在3）中选择的特征向量未记录在其中聚焦的特征向量的复制目的地的每个仓时，在每个仓中记录特征向量。 在专注于规定数量的特征向量并且对每个特征向量执行1）-4）之后，删除复制源哈希表。

公开(公告)号：US20140027498A1

公开(公告)日：2014-01-30

申请号：US14006194

申请日：2012-03-27

Applicant: Takayuki Takasugi ,  Yasuyuki Kaneno ,  Sachio Oki ,  Tomotake Hirata ,  Noboru Mochizuki

Inventor： Takayuki Takasugi ,  Yasuyuki Kaneno ,  Sachio Oki ,  Tomotake Hirata ,  Noboru Mochizuki

IPC: B23K20/12 ,  C22F1/10 ,  C22C19/03

CPC classification number: B23K20/125 ,  B23K20/1255 ,  C22C19/007 ,  C22C19/03 ,  C22F1/10

Abstract: A friction stir processing tool is formed from a Ni-based dual multi-phase intermetallic compound alloy containing rhenium(Re). The Ni-based dual multi-phase intermetallic compound alloy is preferably formed by casting, while gradually cooling, a melt containing all the components of the composition and is preferably heat treated after casting. Moreover, in a method for friction stir processing, a work is softened by friction heat generated when the friction stir processing tool, while rotating, is pressed against the work to be processed. The friction stir processing tool includes the Ni-based dual multi-phase intermetallic compound alloy, and therefore further high hardness is exhibited to improve abrasion resistance, so that even a long period of friction stir processing can be endured.

Abstract translation: 摩擦搅拌处理工具由含有铼（Re）的Ni基双相金属间化合物合金形成。 Ni基双相金属间化合物合金优选通过在逐渐冷却的同时浇铸含有组合物的全部组分的熔体，并且优选在铸造后进行热处理而形成。 此外，在摩擦搅拌处理方法中，当摩擦搅拌处理工具旋转时产生的摩擦热被压在待加工的工件上，使工件软化。 摩擦搅拌处理工具包括Ni基双相金属间化合物合金，因此显示出更高的硬度以改善耐磨性，从而可以承受长时间的摩擦搅拌处理。

公开(公告)号：US08603901B2

公开(公告)日：2013-12-10

申请号：US12742413

申请日：2008-10-29

Applicant: Katsutoshi Izumi ,  Takashi Yokoyama

Inventor： Katsutoshi Izumi ,  Takashi Yokoyama

IPC: H01L29/24 ,  H01L21/22 ,  H01L21/04

CPC classification number: H01L21/265 ,  C30B1/10 ,  C30B29/36 ,  H01L21/02381 ,  H01L21/02488 ,  H01L21/02529 ,  H01L21/02614 ,  H01L21/76251

Abstract: A method including a phosphorous ion introduction step for implanting phosphorous ions from a side of a surface Si layer into an SOI substrate in which the surface Si layer and an embedded oxide layer having a predetermined thickness are formed on an Si base material layer to convert the embedded oxide layer into a PSG layer to lower a softening point. An SiC forming step is performed by heating the SOI substrate having the PSG layer formed therein in an atmosphere of hydrocarbon-based gas to convert the surface Si layer into SiC. Thereafter, the resulting substrate is cooled to form a single crystal SiC layer on a surface thereof.

Abstract translation: 一种包括磷离子引入步骤的方法，用于将磷离子从表面Si层的一侧注入到其中表面Si层和具有预定厚度的嵌入氧化物层的SOI衬底形成在Si基材层上，以将 将氧化物嵌入PSG层以降低软化点。 通过在烃类气体的气氛中加热其中形成有PSG层的SOI衬底以将表面Si层转化为SiC来进行SiC形成步骤。 此后，将所得衬底冷却以在其表面上形成单晶SiC层。

公开(公告)号：US08540987B2

公开(公告)日：2013-09-24

申请号：US12864018

申请日：2009-01-23

Applicant: Masachika Azuma ,  Motohide Takahashi ,  Shunji Kozaki ,  Masafumi Mukamoto ,  Tomoko Kohda ,  Gene Kurosawa ,  Yoshikazu Kurosawa

Inventor： Masachika Azuma ,  Motohide Takahashi ,  Shunji Kozaki ,  Masafumi Mukamoto ,  Tomoko Kohda ,  Gene Kurosawa ,  Yoshikazu Kurosawa

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/00 ,  C12P21/08

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.

Abstract translation: 本文提供了对肉毒中毒疾病和预防肉毒杆菌病有效的手段。 具体提供的是具有彼此具有不同表位的多种人类抗 - 肉毒毒素A型抗体。 还具体提供了用于中和A型肉毒杆菌毒素的组合物，其包含两种或更多种抗体的组合并且具有高中和活性。

公开(公告)号：US20130189149A1

公开(公告)日：2013-07-25

申请号：US13823849

申请日：2011-07-20

Applicant: Takayuki Takasugi ,  Yasuyuki Kaneno

Inventor： Takayuki Takasugi ,  Yasuyuki Kaneno

IPC: C22C19/03 ,  B22D25/06 ,  C22F1/10

CPC classification number: C22C19/03 ,  B22D25/06 ,  C22F1/10

Abstract: The present invention provides an Ni-based intermetallic compound alloy having excellent hardness. The present invention provides an Ni-based dual multi-phase intermetallic compound alloy comprising Ni as a main component, and 5 to 12 atomic % of Al, 11 to 17 atomic % of V and 1 to 5 atomic % of Re, and having a dual multi-phase microstructure including a primary precipitate L12 phase and a (L12+D022) eutectoid microstructure.

Abstract translation: 本发明提供具有优异硬度的Ni基金属间化合物合金。 本发明提供一种以Ni为主成分的Ni系双相金属间化合物合金，5〜12原子％的Al，11〜17原子％的V，1〜5原子％的Re， 双相显微结构包括初级沉淀L12相和（L12 + D022）共析显微组织。