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73 条记录 (耗时 0.037 秒)

    Guidewire and method for surgical procedures
    41.
    再颁专利
    Guidewire and method for surgical procedures 有权

    公开(公告)号：USRE47682E1

    公开(公告)日：2019-11-05

    申请号：US15938638

    申请日：2018-03-28

    申请人： Orthovita, Inc.

    发明人： Wyatt Drake Geist ,  Arden Allen Geist, Sr.

    IPC分类号： A61M29/00 ,  A61B17/17 ,  A61B17/88

    摘要： A surgical guide wire or K-wire and method of use are provided. The K-wire, or guide wire, has opposite end portions and a shank portion in between. One end portion has a deformable end portion that, once outside of a confining guide passage, can be deformed to present a projected forward facing area that is larger than the transverse cross section of the K-wire, or guide wire, while in the passage. The increased area will provide increased resistance to additional forward axial movement into the surgical site.

    Stable compositions containing thrombin and methods for preparation and use thereof
    45.
    发明授权
    Stable compositions containing thrombin and methods for preparation and use thereof 有权

    公开(公告)号：US10124063B2

    公开(公告)日：2018-11-13

    申请号：US14833597

    申请日：2015-08-24

    申请人： Orthovita, Inc.

    发明人： Venkat R. Garigapati

    IPC分类号： A61K38/48 ,  A61K38/39 ,  A61K47/12 ,  A61K9/00 ,  A61K9/08 ,  A61K47/42

    摘要： Compositions comprising thrombin and collagen and methods of preparation thereof are disclosed herein. In one embodiment, a composition comprises thrombin and collagen in an aqueous buffer solution, wherein the buffer solution includes at least one of a first compound represented by Formula I: R1—C(O)—O−M+, wherein R1 is —CH3, —CH2CH2C(O)OH, or —CH2CH2C(O)O−M+, and wherein M+ is a monovalent ion; or a second compound represented by Formula II: R2—C(O)—O−M2+−O—C(O)—R2, wherein R2 is —CH3 or —CH2CH3, and wherein M2+ is a divalent ion. In one embodiment, the buffer solution includes sodium acetate, calcium propionate, and sorbitol.

    Materials and methods for repair of cartilage defects
    46.
    发明授权
    Materials and methods for repair of cartilage defects 有权

    公开(公告)号：US10016527B2

    公开(公告)日：2018-07-10

    申请号：US13793142

    申请日：2013-03-11

    申请人： Orthovita, Inc.

    发明人： Marc Long

    IPC分类号： A61B17/20 ,  A61L27/24 ,  A61B17/16

    CPC分类号： A61L27/24 ,  A61B17/16 ,  A61B17/1604 ,  A61B17/1631 ,  A61L2430/06

    摘要： In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid; allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect; and applying a biomaterial into the defect to produce a clot for cartilage regeneration.

    Stable compositions containing thrombin and methods for preparation and use thereof
    49.
    发明授权
    Stable compositions containing thrombin and methods for preparation and use thereof 有权
    含有凝血酶的稳定组合物及其制备及使用方法

    公开(公告)号：US09149529B2

    公开(公告)日：2015-10-06

    申请号：US13794421

    申请日：2013-03-11

    申请人： Orthovita, Inc.

    发明人： Venkat R. Garigapati

    IPC分类号： A61K38/48 ,  A61K47/12 ,  A61K38/39 ,  A61K9/00 ,  A61K9/08 ,  A61K47/42

    CPC分类号： A61K47/12 ,  A61K9/0019 ,  A61K9/08 ,  A61K38/39 ,  A61K38/4833 ,  A61K47/42 ,  A61K2300/00

    摘要： Compositions comprising thrombin and collagen and methods of preparation thereof are disclosed herein. In one embodiment, a composition comprises thrombin and collagen in an aqueous buffer solution, wherein the buffer solution includes at least one of a first compound represented by Formula I: R1—C(O)—O−M+, wherein R1 is —CH3, —CH2CH2C(O)OH, or —CH2CH2C(O)O−M+, and wherein M+ is a monovalent ion; or a second compound represented by Formula II: R2—C(O)—O−M2+−O—C(O)—R2, wherein R2 is —CH3 or —CH2CH3, and wherein M2+ is a divalent ion. In one embodiment, the buffer solution includes sodium acetate, calcium propionate, and sorbitol.

    摘要翻译： 本文公开了包含凝血酶和胶原的组合物及其制备方法。 在一个实施方案中，组合物包含缓冲溶液中的凝血酶和胶原蛋白，其中所述缓冲溶液包含由式I表示的第一化合物中的至少一种：R1-C（O）-O-M +，其中R1是-CH3， -CH 2 CH 2 C（O）OH或-CH 2 CH 2 C（O）O-M +，其中M +是一价离子; 或由式II表示的第二化合物：R2-C（O）-O-M2 + -O-C（O）-R2，其中R2是-CH3或-CH2CH3，其中M2 +是二价离子。 在一个实施方案中，缓冲溶液包括乙酸钠，丙酸钙和山梨糖醇。

    MIXING SYSTEM AND VALVE ASSEMBLY
    50.
    发明申请
    MIXING SYSTEM AND VALVE ASSEMBLY 有权
    混合系统和阀组件

    公开(公告)号：US20140251438A1

    公开(公告)日：2014-09-11

    申请号：US14190484

    申请日：2014-02-26

    申请人： Orthovita, Inc.

    发明人： John A. Gettings ,  Matthew B. Havener ,  Stephen E. McIlhenny

    IPC分类号： B01F5/00

    CPC分类号： B01F13/0023 ,  A61L27/10 ,  A61L27/12 ,  A61L27/222 ,  A61L27/24 ,  A61L27/3821 ,  A61L27/54 ,  A61L2300/112 ,  A61L2430/02 ,  B01F5/0685 ,  B01F15/0258 ,  B01F2215/0029 ,  B01F2215/0032 ,  Y10T137/0318 ,  Y10T137/8766

    摘要： A mixing system is disclosed in which the system comprises a source of bone-graft or bone-graft-substitute material, a liquid source, and a vacuum source, at least one of the source of bone-graft or bone-graft-substitute material and the liquid source being in communication with the vacuum source. A valve assembly also forms part of the system, the valve assembly having a valve movable between a first position in which a first fluid passageway is created between the source of bone-graft or bone-graft-substitute material and the vacuum, and a second position in which a second fluid passageway is created between the source of bone-graft or bone-graft-substitute material and the liquid source, wherein, in the second position, the valve seals off the first fluid passageway, the vacuum source being adapted to generate a negative-pressure environment, relative to atmospheric pressure, within the valve assembly while the valve is in the first position. Methods of utilizing the aforementioned system are also disclosed.

    摘要翻译： 公开了一种混合系统，其中系统包括骨移植物或骨移植物替代材料源，液体源和真空源，骨移植物源或骨移植物替代材料中的至少一种 液体源与真空源连通。 阀组件还构成系统的一部分，阀组件具有阀，其可在第一位置和第二位置之间移动，第一位置在第一位置和第二位置之间产生第一流体通道，该第一流体通道在骨移植物源或骨移植物替代材料之间产生， 其中在骨移植物源或骨移植物替代材料源和液体源之间产生第二流体通道的位置，其中在第二位置，阀密封第一流体通道，真空源适于 当阀处于第一位置时，在阀组件内产生相对于大气压力的负压环境。 还公开了利用上述系统的方法。