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    Silicon-containing biodegradable material for anti-inflammatory therapy
    43.
    发明授权
    Silicon-containing biodegradable material for anti-inflammatory therapy 有权

    公开(公告)号：US10258644B2

    公开(公告)日：2019-04-16

    申请号：US15150919

    申请日：2016-05-10

    申请人： JIANGSU SYNECOUN MEDICAL TECHNOLOGY CO., LTD.

    发明人： Iwer Baecker ,  Christoph Suscheck

    IPC分类号： A61K31/765 ,  A61K31/80 ,  C04B35/622 ,  C04B35/624 ,  C04B35/626 ,  A61K33/00

    摘要： A method for preventing and/or treating a disease associated with increased interleukin-1β and/or interleukin-6 and/or interleukin-8 activity and/or disease, in which a reduction in the activity of interleukin-1β and/or interleukin-6 and/or interleukin-8 is beneficial for healing includes utilizing a silicon-containing, biodegradable material containing a polyhydroxysilicic acid ethyl ester compound, with the proviso that wound defects including chronic diabetic-neuropathic ulcer, chronic leg ulcer, bedsores, secondary-healing infected wounds, non-irritating, primary-healing wounds, ablative lacerations and/or abrasions, are excluded from said disease that is prevented and/or treated with the silicon-containing, biodegradable material.

    Chymosine enzyme variants
    45.
    发明授权
    Chymosine enzyme variants 有权

    公开(公告)号：US10253305B2

    公开(公告)日：2019-04-09

    申请号：US15782528

    申请日：2017-10-12

    申请人： DSM IP ASSETS B.V.

    发明人： Petrus Jacobus Theodorus Dekker ,  Rene Marcel De Jong ,  Cornelis Marinus Muijlwijk

    IPC分类号： C12N9/64 ,  A23C19/032 ,  A23C19/068 ,  A23C19/072

    摘要： A variant polypeptide having chymosin activity, wherein the variant has an amino acid sequence which, when aligned with the chymosin comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue corresponding to any of amino acids 2, 22, 40, 48, 50, 51, 53, 61, 62, 76, 88, 98, 99, 109, 112, 117, 125, 126, 135, 144, 160, 161, 163, 187, 189, 194, 200, 201, 202, 203, 221, 223, 240, 242, 244, 254, 267, 271, 273, 278, 280, 284, 289, 292, 294 or 295 said positions being defined with reference to SEQ ID NO: 2 and wherein the variant has one or more altered properties as compared with a reference polypeptide having chymosin activity. Such a variant polypeptide may be used in the preparation of a cheese.

    Retail point seed treatment systems and methods
    48.
    发明授权
    Retail point seed treatment systems and methods 有权

    公开(公告)号：US10235644B2

    公开(公告)日：2019-03-19

    申请号：US15431147

    申请日：2017-02-13

    申请人： BAYER CROPSCIENCE LP

    发明人： Greg A. Reineccius ,  Jaco Ernest Van Der Westhuizen ,  Alan W. Geiss ,  Bradley W. May ,  Tharacad S. Ramanarayanan ,  Marc Jean-Marie Andrieux

    IPC分类号： G06Q10/06 ,  G06Q10/08 ,  G05B19/18

    摘要： An automated seed treatment system is adapted for on-site operation at a retail seed distributor. A sealed seed-treater vessel is configured to apply a plurality of chemical treatments to a batch of seed based on a seed treatment recipe. A programmable system controller is electrically coupled to a pump controller of each of a plurality of pump-stations. The programmable system controller is configured to receive a material transfer indication from each of the plurality of pump-stations and issue commands to the pump controller of each pump-station in response to the seed treatment recipe. The programmable system controller is configured to collect operational data representing at least consumption of chemical from the chemical container at each of the pump-stations based on the corresponding material transfer indication during seed treatment and to provide the operational data to a remotely hosted information system located remotely from the site of the retail seed distributor and accessible to at least one third party that is distinct from the retail seed distributor.