公开(公告)号：US20210337752A1

公开(公告)日：2021-11-04

申请号：US17271246

申请日：2019-08-29

Applicant: Clemson University Research Foundation

Inventor： Jeffrey William Adelberg

IPC: A01H4/00 ,  A01G2/10

Abstract: The present disclosure describes a method of culturing and harvesting plant shoot tips. The method includes providing a sterile vessel configured to hold at least one plant with one or more root masses and a first set of shoot tips, cutting across a base of the shoot tips with the one or more root masses held in the vessel to cut a first plurality of cut shoot tips at a first time; then growing a second set of shoot tips from the one or more root masses in the vessel; and then cutting across the one or more root masses held in the vessel to cut a second plurality of cut shoot tips. Plant tissue culture devices are also described.

公开(公告)号：US11150251B2

公开(公告)日：2021-10-19

申请号：US15726766

申请日：2017-10-06

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development

Inventor： Ying Mei ,  Jia Jia ,  Chung-Jen James Chou

IPC: G01N33/68 ,  C07K7/06 ,  C07K7/08 ,  A61P9/10 ,  G01N33/74 ,  C07K14/78 ,  C07K17/02 ,  C07K14/71 ,  C07K14/755 ,  C07K14/52 ,  C07K14/75 ,  C07K14/705 ,  A61K38/00

Abstract: The present invention provides an in vitro method for identifying a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation for the manufacture of a diagnostic or therapeutic agent. The present invention further provides the identified compounds and pharmaceutical compositions, and assays and kits for identifying a compound or using a compound that promotes endothelial cell adhesion, endothelial cell spreading, endothelial cell migration and/or endothelial cell proliferation and is useful for bioprinting.

公开(公告)号：US20210246411A1

公开(公告)日：2021-08-12

申请号：US17244447

申请日：2021-04-29

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： LESLIE SIERAD ,  CHRISTOPHER DELANEY ,  RICHARD PASCAL, III ,  DAN SIMIONESCU ,  AGNETA SIMIONESCU

IPC: C12M1/34 ,  C12M1/00 ,  C12M1/42 ,  C12M3/00

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).

公开(公告)号：US10987449B2

公开(公告)日：2021-04-27

申请号：US16379121

申请日：2019-04-09

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Leslie Sierad ,  Eliza Laine Shaw ,  George Fercana ,  Dan Simionescu

IPC: A61L27/36 ,  A61F2/24

Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.

公开(公告)号：US10899667B2

公开(公告)日：2021-01-26

申请号：US15990188

申请日：2018-05-25

Applicant: Clemson University Research Foundation

Inventor： Rhett C. Smith ,  Andrew G. Tennyson

IPC: C04B26/00 ,  C04B26/28 ,  C04B28/02 ,  C04B18/02 ,  C04B14/06 ,  C04B111/00 ,  C04B103/00

Abstract: In one aspect, composite polymeric composition and related materials are described herein employing waste products from the agricultural and energy industries. Such composite polymeric compositions and materials can repurpose agricultural and petroleum waste products for various applications including, but not limited to, building and/or infrastructure materials. In some embodiments, a composite polymeric composition described herein comprises polysaccharides, lignin or combinations thereof covalently cross-linked via linkages comprising sulfur.

公开(公告)号：US20200276131A1

公开(公告)日：2020-09-03

申请号：US16876812

申请日：2020-05-18

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Naren Vyavahare ,  Aditi Sinha

IPC: A61K9/51 ,  A61K39/44 ,  C07K16/18 ,  C07K16/28 ,  A61K47/69 ,  A61K47/68 ,  A61K47/02

Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers, and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and to prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.

公开(公告)号：US10519324B2

公开(公告)日：2019-12-31

申请号：US15576522

申请日：2016-05-19

Applicant: Clemson University Research Foundation

Inventor： Andrew S. Mount ,  Bin San Chan ,  Mary Beth Johnstone

IPC: C09D5/16 ,  C07K7/08 ,  C07K14/435

Abstract: Materials and methods for prevention of biofouling are described that incorporate the presence of a conotoxin peptide on a surface. The conotoxin peptide is either directly or indirectly adhered to the surface and interferes with the ability of biofouling organisms to settle on the surface.

公开(公告)号：US10132965B2

公开(公告)日：2018-11-20

申请号：US15135813

申请日：2016-04-22

Applicant: LOCKHEED MARTIN CORPORATION ,  THE PENN STATE RESEARCH FOUNDATION ,  CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Clara Rivero Baleine ,  Theresa S. Mayer ,  Jonathan David Musgraves ,  Kathleen Richardson ,  Peter Wachtel

IPC: G02B3/00 ,  C03C4/00 ,  C03C23/00 ,  C03B32/02 ,  G02B1/02 ,  C03B25/00 ,  C03C3/32 ,  C03C10/00 ,  G02B6/12 ,  G02B6/10

Abstract: A refractive index device and method of making it include obtaining a glass structure comprising a plurality of nucleation sites. The glass structure is formed from a glass composition that comprises a first chemical component and a second chemical component. A crystal of the second chemical component has a different second refractive index from a first refractive index of the first chemical component. Each nucleation site defines where a crystal of the second chemical component can be grown. The method includes causing crystals of the second chemical component to grow in situ at a set of the plurality of nucleation sites in order to produce a spatial gradient of a refractive index in the glass structure.

公开(公告)号：US20180154779A1

公开(公告)日：2018-06-07

申请号：US15571739

申请日：2016-05-06

Applicant: The Regents of the University of Michigan ,  Clemson University Research Foundation

Inventor： Saemin Chol ,  Jason Benjamin Siegel ,  Seyed Yasha Parvini Oskoui ,  Ernesto G. Urdaneta

IPC: B60L11/00 ,  B60L11/18 ,  H02J7/14 ,  H02J7/34

CPC classification number: B60L11/005 ,  B60L1/00 ,  B60L50/40 ,  B60L58/20 ,  B60L58/22 ,  B60L2240/547 ,  H02J7/1423 ,  H02J7/345 ,  Y02T10/7005 ,  Y02T10/7022 ,  Y02T10/7061 ,  Y02T10/7066

Abstract: A system includes a first energy storage device, a second energy storage device coupled to the first energy storage device and charged via a charging current from the first energy storage device, a power controller having a processor, a memory coupled to the processor and on which charging current instructions are stored, and a converter coupled to the processor and directed via switch control signals from the processor, and an output terminal via which power is provided to a load of the system. The converter is disposed between the first energy storage device and the output terminal. The converter is disposed between the first and second energy storage devices and configured to control a level of the charging current in accordance with the switch control signals. The charging current instructions are executed by the processor to cause the processor to generate the switch control signals such that the level of the charging current is regulated.

公开(公告)号：US20180117819A1

公开(公告)日：2018-05-03

申请号：US15795660

申请日：2017-10-27

Applicant: Clemson University Research Foundation ,  The United States Department of Defense Department of the Army

Inventor： Philip Brown ,  Quoc Tien Truong ,  Nicole Hoffman

IPC: B29C47/00 ,  D01D4/02 ,  D03D15/00

CPC classification number: B29C48/05 ,  B29C48/0018 ,  B29C48/30 ,  B29C48/345 ,  B29C48/875 ,  B29K2995/0093 ,  D01D4/02 ,  D01D5/253 ,  D01F6/06 ,  D01F6/60 ,  D01F8/06 ,  D01F8/12 ,  D03D15/00 ,  D06M11/78 ,  D06M23/08 ,  D06M2200/05 ,  D06M2200/10

Abstract: Invention is directed to a method of extruding an omni-phobic filament comprising: extruding a co-polymer filament having a first polymer at a core having generally a circular cross-section, and a second polymer disposed at a perimeter of the core wherein the second polymer is dissolvable; creating channels disposed at the perimeter of the core by dissolving the second polymer; creating trapezoidal cross-section features having a distal angle less than 70°, a top edge greater than a side length and a bottom length less than the side length; and adding nano-sized particles to at least one of the top edge and one or more sides or any combination thereof.