公开(公告)号：US20170087245A1

公开(公告)日：2017-03-30

申请号：US15264498

申请日：2016-09-13

Applicant: Dynavax Technologies Corporation

Inventor： William L. HEYWARD

IPC: A61K39/29 ,  A61K39/39 ,  C12N7/00

CPC classification number: A61K39/292 ,  A61K31/713 ,  A61K39/12 ,  A61K39/39 ,  A61K39/42 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/575 ,  C07K16/08 ,  C07K16/082 ,  C12N7/00 ,  C12N15/113 ,  C12N15/86 ,  C12N2730/10134 ,  C12N2730/10171 ,  C12N2770/20033

Abstract: The present invention relates to immunization of hypo-responsive groups of individuals. In particular, the present invention provides methods and compositions for eliciting a potent immune response to hepatitis B virus in individuals in need thereof.

公开(公告)号：US20170067055A1

公开(公告)日：2017-03-09

申请号：US15232502

申请日：2016-08-09

Applicant: Dynavax Technologies Corporation

Inventor： Dino DINA ,  Karen L. FEARON ,  Jason MARSHALL

IPC: C12N15/117

CPC classification number: C12N15/117 ,  A61K39/0011 ,  A61K45/06 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/333 ,  C12N2310/335 ,  C12N2310/336

Abstract: The invention provides immunomodulatory polynucleotides and methods for immunomodulation of individuals using the immunomodulatory polynucleotides.

Abstract translation: 本发明提供免疫调节多核苷酸和使用免疫调节多核苷酸免疫调节个体的方法。

公开(公告)号：US20160213774A1

公开(公告)日：2016-07-28

申请号：US15004860

申请日：2016-01-22

Applicant: Dynavax Technologies Corporation

Inventor： Gary S. Ott ,  Robert J. Milley ,  Robert L. Coffman ,  Radwan Kiwan ,  Holger Kanzler

IPC: A61K39/39 ,  C07H1/00 ,  A61K39/07 ,  C07H21/04 ,  A61K31/7125

CPC classification number: A61K39/39 ,  A61K31/7125 ,  A61K39/07 ,  A61K39/12 ,  A61K47/60 ,  A61K47/61 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/572 ,  A61K2039/575 ,  C07H21/00 ,  C07H21/04 ,  C12N2730/10134

Abstract: The present disclosure relates to branched and linear chimeric compounds containing both nucleic acid and non-nucleic acid moieties, as well as to polynucleotides. The present disclosure also relates to uses thereof for stimulating an immune response, and to methods for preparation of the branched chimeric compounds.

Abstract translation: 本公开涉及含有核酸和非核酸部分以及多核苷酸的支链和线性嵌合化合物。 本公开还涉及其用于刺激免疫应答的用途，以及制备支链嵌合化合物的方法。

公开(公告)号：US09347064B2

公开(公告)日：2016-05-24

申请号：US14553857

申请日：2014-11-25

Applicant: Dynavax Technologies Corporation

Inventor： Franck Barrat ,  Robert L. Coffman ,  Cristiana Guiducci

IPC: A61K48/00 ,  C12N15/117 ,  A61K31/573 ,  A61K31/7125

CPC classification number: C12N15/117 ,  A61K31/573 ,  A61K31/7125 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/30 ,  C12N2320/31 ,  Y02A50/411 ,  C12N2310/3521

Abstract: The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.

公开(公告)号：US20160003807A1

公开(公告)日：2016-01-07

申请号：US14694919

申请日：2015-04-23

Applicant: Dynavax Technologies Corporation

Inventor： Franck BARRAT ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI

IPC: G01N33/50 ,  C07K14/705 ,  C12N5/0789

CPC classification number: G01N33/5073 ,  A01K67/0271 ,  A01K67/0278 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/0387 ,  C07K14/705 ,  C07K14/70596 ,  C12N5/0647 ,  C12N2510/00 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/5038

Abstract: Provided herein are human Toll-like receptor 8 (TLR8)-expressing transgenic animals and methods of use thereof.

Abstract translation: 本文提供了表达转基因动物的人Toll样受体8（TLR8）及其使用方法。

公开(公告)号：US09028845B2

公开(公告)日：2015-05-12

申请号：US14030975

申请日：2013-09-18

Applicant: Dynavax Technologies Corporation

Inventor： Karen L. Fearon ,  Dino Dina ,  Stephen F. Tuck

IPC: A61K45/00 ,  A61K39/00 ,  A61K47/48 ,  A61K39/29 ,  C07H15/18 ,  C07H21/00 ,  C12N15/117

CPC classification number: A61K47/48023 ,  A61K39/12 ,  A61K39/292 ,  A61K47/54 ,  A61K47/549 ,  A61K2039/55561 ,  C07H15/18 ,  C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/332 ,  C12N2310/351 ,  C12N2310/3519 ,  C12N2310/52 ,  C12N2730/10134

Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.

Abstract translation: 本发明提供免疫调节化合物和使用免疫调节化合物免疫调节个体的方法。

公开(公告)号：US20150024007A1

公开(公告)日：2015-01-22

申请号：US14335790

申请日：2014-07-18

Applicant: Dynavax Technologies Corporation

Inventor： Edith M. HESSEL ,  Robert L. Coffman

IPC: A61K39/39 ,  A61K39/35 ,  A61K39/36

CPC classification number: A61K39/39 ,  A01K67/027 ,  A01K2207/10 ,  A01K2227/105 ,  A01K2267/0387 ,  A61K31/7088 ,  A61K39/35 ,  A61K39/36 ,  A61K2039/545 ,  A61K2039/55561 ,  A61K2039/57

Abstract: The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.

公开(公告)号：US20040136948A1

公开(公告)日：2004-07-15

申请号：US10739518

申请日：2003-12-17

Applicant: Dynavax Technologies Corporation

Inventor： Karen L. Fearon

IPC: A61K048/00

CPC classification number: A61K39/292 ,  A61K39/12 ,  A61K39/36 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/57 ,  C12N2730/10134 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y10S514/885

Abstract: The invention provides immunomodulatory compounds and methods for immunomodulation of cells and individuals using the immunomodulatory compounds.

Abstract translation: 本发明提供免疫调节化合物和使用免疫调节化合物免疫调节细胞和个体的方法。

公开(公告)号：US20250163105A1

公开(公告)日：2025-05-22

申请号：US18723407

申请日：2022-12-22

Applicant: Dynavax Technologies Corporation

Inventor： Robert S. JANSSEN

IPC: C07K14/005 ,  A61K39/00 ,  A61P31/22

Abstract: The present disclosure relates to methods for increasing cell-mediated immunity against varicella zoster virus (VZV) in a human subject in need thereof by administration of an immunogenic composition comprising effective amounts of a VZV glycoprotein E antigen and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for prevention of herpes zoster and/or postherpetic neuralgia.

公开(公告)号：US12296002B2

公开(公告)日：2025-05-13

申请号：US17351363

申请日：2021-06-18

Applicant: Medigen Vaccine Biologics Corporation ,  Dynavax Technologies Corporation

Inventor： Tsun-Yung Kuo ,  Charles Chen ,  Chung-Chin Wu ,  Yi-Jiun Lin ,  Meei-Yun Lin ,  Yu-Chi Wu ,  John Darren Campbell ,  Robert S. Janssen ,  David Novack ,  Robert Coffman ,  Paula Traquina

IPC: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C07K14/165 ,  C07K14/245 ,  A61K39/00

Abstract: The present invention relates to an immunogenic composition against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially to an immunogenic composition having a recombinant SARS-CoV-2 S protein and adjuvant.