公开(公告)号：US4989277A

公开(公告)日：1991-02-05

申请号：US317929

申请日：1989-03-02

申请人： Osamu Tsutsui ,  Hisato Haraga ,  Atsuo Makita ,  Hirofumi Takeuchi

发明人： Osamu Tsutsui ,  Hisato Haraga ,  Atsuo Makita ,  Hirofumi Takeuchi

IPC分类号： E03D5/10 ,  F16K31/00

CPC分类号： F16K31/007 ,  E03D5/10 ,  Y10S4/03

摘要： A toilet bowl flushing device washes out a toilet bowl while controlling the flow rate of flushing water supplied to the toilet bowl for a maximum flushing effect. The toilet bowl flushing device includes water supply apparatus for supplying flushing water to the toilet bowl, the water supply apparatus including a flow rate control valve for controlling a rate of flow of flushing water to be supplied to the toilet bowl, an actuator for actuating the flow rate control valve, and a control subsystem operable according to a predetermined flow rate pattern program for controlling operation of the actuator to vary the rate of flow of flushing water in one flushing cycle with respect to time from a time to start flushing the toilet bowl to a time to finish flushing the toilet bowl.

公开(公告)号：US4971106A

公开(公告)日：1990-11-20

申请号：US246461

申请日：1988-09-19

申请人： Osamu Tsutsui ,  Hisato Haraga ,  Kinya Arita ,  Atsuo Makita ,  Hirofumi Takeuchi ,  Ryoichi Tsukada

发明人： Osamu Tsutsui ,  Hisato Haraga ,  Kinya Arita ,  Atsuo Makita ,  Hirofumi Takeuchi ,  Ryoichi Tsukada

IPC分类号： G05D11/16 ,  G05D23/13 ,  H01L41/09

CPC分类号： H02N2/023 ,  G05D23/1393 ,  Y10T137/87249 ,  Y10T137/87684 ,  Y10T137/87877

摘要： An automatically operating valve for regulating water flow, especially a mixing valve for automatically mixing hot water and cold water to obtain a mixed water of a desired temperature is characterized by employing piezoelectric actuators for operating valve bodies thereof. Due to such a construction, the valve can not only fully close or open but also carries out the fine flow amount control by regulating the opening rate or angle of the valve body. Especially in case the automatically operating valve is a mixing valve, the mixing ratio of hot water and cold water can be accurately regulated so that the mixed water of a desired temperature can be always automatically obtained.

公开(公告)号：US4761836A

公开(公告)日：1988-08-09

申请号：US947930

申请日：1986-12-30

申请人： Osamu Tsutsui ,  Hirohiko Yasuda ,  Hidehiko Kuwahara ,  Hirofumi Takeuchi ,  Keiji Hayashi ,  Mitsuhiro Higuchi ,  Akio Fujii

发明人： Osamu Tsutsui ,  Hirohiko Yasuda ,  Hidehiko Kuwahara ,  Hirofumi Takeuchi ,  Keiji Hayashi ,  Mitsuhiro Higuchi ,  Akio Fujii

IPC分类号： E03D9/08 ,  F16K11/074 ,  G05D23/13 ,  A47K3/20

CPC分类号： E03D9/08 ,  F16K11/0746 ,  G05D23/1393

摘要： A washing device for parts of human body being such as anus or private part of female is disclosed. Such washing device is substantially characterized in that the heated-water supply source and the cold-water supply source which are connected with a heated-and-cold-water mixing valve respectively are both installed outside of a toilet chamber or a bathroom and a mixed-water ejecting nozzle is connected to a downstream end of a mixed-water supply passage which has an upper end thereof connected to an outlet opening of the heated-and-cold-water mixing valve. Due to such construction, the washing deivce can extremely improve the heating efficiency so as to enable the considerable energy saving and can unnecessitate the installation of the heat exchangers in the washing device so as to make full use of a narrow space of a toilet chamber or a bathroom.

摘要翻译： 公开了一种用于人体部分的洗涤装置，例如肛门或女性的私人部分。 这种洗涤装置的特征在于，分别与加热和冷水混合阀连接的加热水供应源和冷水供应源都安装在厕所室或浴室的外部，并且混合 水喷射喷嘴连接到混合水供应通道的下游端，混合水供应通道的上端连接到加热和冷水混合阀的出口。 由于这样的结构，洗涤活动可以极大地提高加热效率，从而能够节省大量能量，并且不需要在洗涤装置中安装热交换器，以充分利用厕所室的狭窄空间或 一个卫生间。

公开(公告)号：US09750694B2

公开(公告)日：2017-09-05

申请号：US14108826

申请日：2013-12-17

申请人： Hirofumi Takeuchi ,  OTSUKA PHARMACEUTICAL CO., LTD.

发明人： Hirofumi Takeuchi ,  Koji Nakano ,  Hidekazu Toyobuku

IPC分类号： A61K47/32 ,  A61K47/36 ,  A61K9/127 ,  A61K9/00 ,  A61K45/06 ,  C12N15/88 ,  A61K48/00

CPC分类号： A61K9/1277 ,  A61K9/007 ,  A61K9/0078 ,  A61K9/1271 ,  A61K45/06 ,  A61K47/32 ,  A61K47/36 ,  A61K48/00 ,  A61K48/0075 ,  C12N15/88 ,  C12N2810/10

摘要： An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration.By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.

公开(公告)号：US09114070B2

公开(公告)日：2015-08-25

申请号：US12919807

申请日：2009-02-26

申请人： Hideaki Hara ,  Hirofumi Takeuchi

发明人： Hideaki Hara ,  Hirofumi Takeuchi

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K31/00

CPC分类号： A61K9/0048 ,  A61K9/1272 ,  A61K31/00

摘要： The invention provides a liposome for delivery to the posterior segment of the eye, comprising (A) a phospholipid, (B) a charged substance, and/or (C) a membrane-reinforcing substance; the liposome having a rigidity that provides the liposome with cell membrane permeability, and having a mean particle diameter of 1 μm or less; and a pharmaceutical composition for a disease in the posterior segment of an eye, comprising a drug encapsulated in the liposome. The liposome is delivered to the posterior segment of the eye by instillation, and is non-cytotoxic; and the pharmaceutical composition for a disease in the posterior segment of the eye comprises the liposome.

摘要翻译： 本发明提供一种用于输送到眼后段的脂质体，包括（A）磷脂，（B）带电物质和/或（C）膜增强物质; 所述脂质体具有赋予所述脂质体细胞膜通透性并且平均粒径为1μm以下的刚性; 和用于眼后段疾病的药物组合物，其包含包封在脂质体中的药物。 通过滴注将脂质体递送至眼后段，是非细胞毒性的; 并且眼睛后段中疾病的药物组合物包含脂质体。

公开(公告)号：US09020774B2

公开(公告)日：2015-04-28

申请号：US13033924

申请日：2011-02-24

申请人： Hiroyuki Kishida ,  Toru Morita ,  Yoshiji Takahashi ,  Kou Ohno ,  Takashi Nagase ,  Kenji Omata ,  Hirofumi Takeuchi

发明人： Hiroyuki Kishida ,  Toru Morita ,  Yoshiji Takahashi ,  Kou Ohno ,  Takashi Nagase ,  Kenji Omata ,  Hirofumi Takeuchi

IPC分类号： G01B7/30 ,  G01D5/244 ,  G01B21/22 ,  G01D5/347 ,  G01D5/58 ,  G01D5/56 ,  G01D5/14

CPC分类号： G01D5/14 ,  G01B7/30 ,  G01B21/22 ,  G01D5/145 ,  G01D5/2449 ,  G01D5/3473 ,  G01D5/56 ,  G01D5/58 ,  G05B15/02 ,  G05D3/00

摘要： An encoder system includes: a first single-rotation absolute encoder that outputs a first signal corresponding to an angular position of a first rotatable shaft; a power transmission device that transmits the power of the first shaft to a second rotatable shaft with a predetermined transmission ratio; a second single-rotation absolute encoder that outputs a second signal corresponding to an angular position of the second shaft; and a signal processing section that generates data related to the rotation count of the first shaft based on at least the first signal and the second signal.

摘要翻译： 编码器系统包括：第一单旋转绝对编码器，其输出对应于第一可旋转轴的角位置的第一信号; 动力传递装置，其以预定的传动比将第一轴的动力传递到第二可旋转轴; 输出对应于所述第二轴的角位置的第二信号的第二单旋转绝对编码器; 以及信号处理部，至少基于第一信号和第二信号生成与第一轴的旋转数相关的数据。

公开(公告)号：US08977516B2

公开(公告)日：2015-03-10

申请号：US13033924

申请日：2011-02-24

申请人： Hiroyuki Kishida ,  Toru Morita ,  Yoshiji Takahashi ,  Kou Ohno ,  Takashi Nagase ,  Kenji Omata ,  Hirofumi Takeuchi

发明人： Hiroyuki Kishida ,  Toru Morita ,  Yoshiji Takahashi ,  Kou Ohno ,  Takashi Nagase ,  Kenji Omata ,  Hirofumi Takeuchi

IPC分类号： G01B7/30 ,  G01D5/244 ,  G01B21/22 ,  G01D5/347 ,  G01D5/58 ,  G01D5/56 ,  G01D5/14

摘要： An encoder system includes: a first single-rotation absolute encoder that outputs a first signal corresponding to an angular position of a first rotatable shaft; a power transmission device that transmits the power of the first shaft to a second rotatable shaft with a predetermined transmission ratio; a second single-rotation absolute encoder that outputs a second signal corresponding to an angular position of the second shaft; and a signal processing section that generates data related to the rotation count of the first shaft based on at least the first signal and the second signal.

公开(公告)号：US20110008421A1

公开(公告)日：2011-01-13

申请号：US12919807

申请日：2009-02-26

申请人： Hideaki Hara ,  Hirofumi Takeuchi

发明人： Hideaki Hara ,  Hirofumi Takeuchi

IPC分类号： A61K9/127 ,  A61P27/02

CPC分类号： A61K9/0048 ,  A61K9/1272 ,  A61K31/00

摘要： The invention provides a liposome for delivery to the posterior segment of the eye, comprising (A) a phospholipid, (B) a charged substance, and/or (C) a membrane-reinforcing substance; the liposome having a rigidity that provides the liposome with cell membrane permeability, and having a mean particle diameter of 1 μm or less; and a pharmaceutical composition for a disease in the posterior segment of an eye, comprising a drug encapsulated in the liposome. The liposome is delivered to the posterior segment of the eye by instillation, and is non-cytotoxic; and the pharmaceutical composition for a disease in the posterior segment of the eye comprises the liposome.

摘要翻译： 本发明提供一种用于输送到眼后段的脂质体，包括（A）磷脂，（B）带电物质和/或（C）膜增强物质; 所述脂质体具有赋予所述脂质体细胞膜通透性并且平均粒径为1μm以下的刚性; 和用于眼后段疾病的药物组合物，其包含包封在脂质体中的药物。 通过滴注将脂质体递送至眼后段，是非细胞毒性的; 并且眼睛后段中疾病的药物组合物包含脂质体。

公开(公告)号：US20070128273A1

公开(公告)日：2007-06-07

申请号：US10551901

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

IPC分类号： A61K9/20

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2095

摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.

摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，并且当进行X射线衍射测定时，该材料在对应于d为1nm以上的衍射角（2θ）处表现出一个或多个峰）; 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。

公开(公告)号：US5806761A

公开(公告)日：1998-09-15

申请号：US746644

申请日：1996-11-12

申请人： Masatoshi Enoki ,  Osamu Tokunaga ,  Setsuo Ito ,  Masaaki Itoh ,  Hirofumi Takeuchi

发明人： Masatoshi Enoki ,  Osamu Tokunaga ,  Setsuo Ito ,  Masaaki Itoh ,  Hirofumi Takeuchi

IPC分类号： F16K31/00 ,  F16K31/70 ,  G05D23/02 ,  G05D23/13

CPC分类号： G05D23/025 ,  F16K31/002 ,  G05D23/1346 ,  G05D23/1353

摘要： In a combination faucet device (10) according to the invention, a movable valve member (160) slidingly moves relative to a main casing (30) to change a mixing ratio of high-temperature water supplied from a hot water port (116) to low-temperature water supplied from a cold water port (106). The movable valve member (160) is pressed by a temperature sensitive spring (130) in a first direction while being pressed by a bias spring (150) in a second direction opposite to the first direction. The temperature sensitive spring (130) is exposed to a water mixture and varies its spring constant according to the temperature of the water mixture. The temperature sensitive spring (130) accordingly moves the movable valve member (160) in a direction for decreasing the ratio of the high-temperature water to a certain position where the spring force of the temperature sensitive spring (130) balances with the spring force of the bias spring (150), thus allowing a water mixture adjusted to a target temperature.

摘要翻译： 在根据本发明的组合龙头装置（10）中，可移动阀构件（160）相对于主壳体（30）滑动移动，以将从热水口（116）供应的高温水的混合比改变为 从冷水口（106）供应的低温水。 可移动阀构件（160）在温度敏感弹簧（130）的第一方向上被按压在与第一方向相反的第二方向的偏置弹簧（150）上。 温度敏感弹簧（130）暴露于水混合物，并根据水混合物的温度改变其弹簧常数。 因此，温度敏感弹簧130相应地使可移动阀构件160沿着使温度高的水比与温度敏感弹簧130的弹簧力与弹簧力平衡的特定位置的方向移动 的偏压弹簧（150），从而允许将水混合物调节到目标温度。