公开(公告)号：US20170231561A1

公开(公告)日：2017-08-17

申请号：US15409944

申请日：2017-01-19

Applicant: Hitachi, Ltd. ,  JICHI MEDICAL UNIVERSITY

Inventor： Stephanie SUTOKO ,  Tsukasa FUNANE ,  Hiroki SATO ,  Atsushi MAKI ,  Yukifumi MONDEN ,  Masako NAGASHIMA ,  Ippeita DAN ,  Takanori YAMAGATA

IPC: A61B5/00 ,  A61B5/0476 ,  A61B5/04

CPC classification number: A61B5/4848 ,  A61B5/0059 ,  A61B5/04012 ,  A61B5/0476 ,  A61B5/4064 ,  A61B5/6814 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/742 ,  A61B2560/0475 ,  G16H20/10 ,  G16H50/20 ,  G16H50/30 ,  G16H70/40

Abstract: Provided herein is a technique for effectively and quantitatively evaluating the symptom improving effect of a treatment given to a subject (patient). The invention provides a technique for diagnosing, evaluating, monitoring, and predicting drug efficacy in individuals (patients) with possible mental disorders such as ADHD, autism, and depression. Specifically, patient's data are simultaneously analyzed using several variables, such as biological measurements (e.g., brain activity measurements) and cognitive performance assessments, involving, for example, a patient (dependent variable), a medication type and dose (independent variables), a diagnosis profile score (DSM) and a rating scale (manifest variables), and an efficacy index (a predictor variable of a future treatment).

公开(公告)号：US20160346304A1

公开(公告)日：2016-12-01

申请号：US14370134

申请日：2014-04-17

Applicant: JICHI MEDICAL UNIVERSITY ,  MATSUTANI CHEMICAL INDUSTRY CO., LTD.

Inventor： Toshihiko Yada ,  Yusaku Iwasaki ,  Tomonori Kimura ,  Kazuhiro Ohkuma

IPC: A61K31/7004 ,  A23L33/125 ,  A23L33/00 ,  A61K9/00

CPC classification number: A61K31/7004 ,  A23L33/125 ,  A23L33/30 ,  A23V2002/00 ,  A61K9/0053 ,  A23V2200/332 ,  A23V2250/60

Abstract: Object: To provide an agent for sustaining satiety or a method for sustaining satiety, with which an individual's food intake is reduced by sustaining satiety, and as a result, pathological conditions such as obesity due to overeating can be prevented and improved.Means for Resolution: An agent for sustaining satiety containing D-psicose as an active ingredient and a method for sustaining satiety by the ingestion of D-psicose.Advantageous Effect: Satiety can be sustained although the increase in blood glucose level after eating is suppressed. A means for sustaining satiety which is useful for those who are anxious about their blood glucose level and those who are health conscious can be provided.

Abstract translation: 有益效果：抑制饮食后血糖水平升高，可以持续保持饱和感。 维持饱腹感的手段对于那些对血糖水平焦虑的人和对健康有意识的人来说是有用的。

公开(公告)号：US12186112B2

公开(公告)日：2025-01-07

申请号：US17482297

申请日：2021-09-22

Applicant: OMRON HEALTHCARE CO., LTD. ,  JICHI MEDICAL UNIVERSITY

Inventor： Ayako Kokubo ,  Mitsuo Kuwabara ,  Shingo Yamashita ,  Kazuomi Kario

IPC: A61B5/021 ,  A61B5/00 ,  G06T11/00 ,  G06T11/20

Abstract: According to the present invention, blood pressure surges is detected from time-series data on blood pressure of a subject that varies with pulsation based on predetermined determination criteria. A feature amount indicating a characteristic of each blood pressure surge thus detected is obtained. Statistical processing is performed on an occurrence number of the blood pressure surges thus detected and/or the feature amount to obtain a statistical amount for each of time slots. A required attention degree indicating a level of attention being required to the blood pressure surge is obtained for each of the time slots based on the statistical amount of the occurrence number of the blood pressure surges and/or the feature amount. The required attention degree thus obtained and/or the statistical amount are displayed side by side for each of the time slots on a display screen.

公开(公告)号：US20240344942A1

公开(公告)日：2024-10-17

申请号：US18631687

申请日：2024-04-10

Applicant: JICHI MEDICAL UNIVERSITY ,  EIKEN KAGAKU KABUSHIKI KAISHA

Inventor： Kazutaka FUJITA ,  Koichi HAGIWARA

IPC: G01N1/30 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: G01N1/30 ,  C12N15/1003 ,  C12Q1/6886

Abstract: A method for preparing a sample from a specimen includes treating a biopsy tissue taken from a lung cancer patient with negative pressure in an isotonic solution to release a cell from the biopsy tissue, collecting the isotonic solution containing the released cell, and mixing the collected isotonic solution and a cytologic specimen collected from the lung cancer patient together to obtain a cell suspension, wherein the cytologic specimen is one or more selected from the group consisting of a bronchial lavage fluid, a bronchoalveolar lavage fluid, a bronchial scraping lavage fluid and a puncture needle lavage fluid, and wherein the biopsy tissue and the cytologic specimen contain a tumor cell.

公开(公告)号：US11674156B2

公开(公告)日：2023-06-13

申请号：US16916313

申请日：2020-06-30

Applicant: Jichi Medical University

Inventor： Shinichi Muramatsu

IPC: C12N15/86 ,  C12N15/861 ,  A61K48/00 ,  C12N15/113 ,  A61K38/18 ,  A61K38/44 ,  A61K38/48

CPC classification number: C12N15/861 ,  A61K48/005 ,  C12N15/86 ,  A61K38/185 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/44 ,  A61K38/48 ,  C12N15/1137 ,  C12N2310/141 ,  C12N2320/32 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: The present invention provides a means for transferring a therapeutic gene of interest into a nervous system cell by a highly-efficient and simpler means. More specifically, the present invention provides a recombinant vector that uses an adeno-associated virus (AAV), a method for manufacturing the recombinant vector, and a method for using the recombinant vector. More specifically, recombinant adeno-associated virus virions, which are capable of passing through the brain-brain barrier, for transferring a therapeutic genes of interest into a nervous system cell in a highly-efficient manner, a drug composition containing the recombinant adeno-associated virus virions, a method for manufacturing the recombinant adeno-associated virus virions, and a kit or the like are provided.

公开(公告)号：US20230129423A1

公开(公告)日：2023-04-27

申请号：US17914504

申请日：2021-03-19

Applicant: JICHI MEDICAL UNIVERSITY ,  TEIJIN MEDICAL TECHNOLOGIES CO., LTD.

Inventor： Yuji Kaneda ,  Yasuhiro Kawabe ,  Katsuhiro Mikami ,  Masumi Hirata

IPC: A61B17/122

Abstract: A medical instrument, comprising a flexible band body having a distal end and a proximal end; a flexible first rod-shaped body having a distal end and a proximal end; and a flexible second rod-shaped body having a distal end and a proximal end, wherein the distal end of the band body and the proximal end of the first rod-shaped body are connected, the distal end of the first rod-shaped body and the proximal end of the second rod-shaped body are connected via a connecting portion, the band body is more flexible than the first rod-shaped body and the second rod-shaped body, the second rod-shaped body has a locking part, the band body has a locking corresponding part, when tightened the locking part and the locking corresponding part, the proximal end of the first rod-shaped body and the distal end of the second rod-shaped body are connected via a part of the band body, the connecting portion is inflected, and a loop having a desired size can be formed by the first rod-shaped body, the second rod-shaped body and the part of the band body, and the second rod-shaped body further has a feature for placing the rest of the band body along an outer surface of the second rod-shaped body in the direction from the distal end to the proximal end of the second rod-shaped body when had been tightened the locking part and the locking corresponding part.

公开(公告)号：US11337704B2

公开(公告)日：2022-05-24

申请号：US16641623

申请日：2018-08-24

Applicant: JICHI MEDICAL UNIVERSITY

Inventor： Yuji Kaneda

IPC: A61B17/12

Abstract: This tool is for treating an excised end of a body organ and is provided with: a long and thin, flexible first band section having a distal end and a proximal end that are made of a biodegradable-absorptive polymer; a long and thin, flexible second band section having a distal end and a proximal end that are made of a biodegradable-absorptive polymer; and a first locking section having a first ratchet claw made of a biodegradable-absorptive polymer, wherein the first locking section is formed at the distal end of the second band section, the distal end of the first band section and the proximal end of the second band section are joined together, at least one ratchet tooth that is capable of meshing with the first ratchet claw is formed on the external surface of the first band section, and the engagement of the ratchet tooth with the first ratchet claw forms a flattened ring which is used to bind a body organ so as to ligate a tube or cavity that opens at an excised end of the body organ.

公开(公告)号：US20210369922A1

公开(公告)日：2021-12-02

申请号：US17403232

申请日：2021-08-16

Applicant: Jichi Medical University ,  Otsuka Pharmaceutical Factory, Inc.

Inventor： Tomonori Yano ,  Atsushi Ohhata ,  Toshihiro Goto ,  Yuji Hiraki

IPC: A61L31/04 ,  A61L31/14 ,  A61B1/015 ,  A61L31/02

Abstract: The purpose of the present invention is to provide a viscoelastic composition having excellent operability, which is suitable for use in securing the field of view of an endoscope when opaque dark-colored liquid accumulates inside a canal and obstructs the field of view of the endoscope, the viscoelastic composition securing the field of view by pushing the liquid aside, and to provide a method for securing the field of view of an endoscope using the viscoelastic composition. The viscoelastic composition for securing the field of view of an endoscope comprises a substance having viscoelastic properties and water, preferably has a hardness of 550 N/m2 or less, a viscosity (25° C.) of 200 to 2,000 mPa·s, and a loss tangent of 0.6 or less, and more preferably has an electrical conductivity of 250 μS/cm or less. The method for securing the field of view of an endoscope comprises feeding the viscoelastic composition from a proximal part of the endoscope, through a channel, into a distal part of the endoscope.

公开(公告)号：US20210071202A1

公开(公告)日：2021-03-11

申请号：US17042819

申请日：2019-03-28

Applicant: Jichi Medical University

Inventor： Yutaka Hanazono ,  Hiromasa Hara ,  Hideki Uosaki

IPC: C12N15/90 ,  C12N5/10 ,  C12N5/0789 ,  C07K14/715 ,  A61P37/04

Abstract: A genome editing method for an isolated cell, the method comprising introducing foreign DNA into a targeted genome with homologous recombination of at least one of a 5′-end or a 3′-end of the foreign DNA, where the foreign DNA has homology arms, each with a length of less than 500 bp.

公开(公告)号：US20210030823A1

公开(公告)日：2021-02-04

申请号：US16964142

申请日：2019-01-25

Applicant: TOKUSHIMA UNIVERSITY ,  JICHI MEDICAL UNIVERSITY ,  GENE THERAPY RESEARCH INSTITUTION CO., LTD.

Inventor： Kohji ITOH ,  Daisuke TSUJI ,  Shinichi MURAMATSU ,  Katsuhito ASAI

IPC: A61K35/76 ,  C12N7/00 ,  A61P25/28

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.