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    METHOD AND APPARATUS FOR TREATMENT ENHANCEMENT IN ACOUSTIC PROCESSING OF SAMPLES
    44.
    发明申请
    METHOD AND APPARATUS FOR TREATMENT ENHANCEMENT IN ACOUSTIC PROCESSING OF SAMPLES 有权
    用于处理加压样品的方法和装置

    公开(公告)号：US20090317884A1

    公开(公告)日：2009-12-24

    申请号：US12489693

    申请日：2009-06-23

    Applicant: James A. Laugharn, JR.

    Inventor： James A. Laugharn, JR.

    IPC: C12N13/00 ,  C12M1/33

    CPC classification number: G01N1/286 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N2035/00554

    Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using an energy director positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

    Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件以减少和/或消除样品/气体界面处的顶部空间来控制其中声学处理样品的处理体积。 可以例如通过使用至少部分地定位在样品中的能量导向器来控制声能和样品之间的相互作用，这有助于减少否则将发生的飞溅或其它样品喷射。

    Apparatus and methods for sample preparation
    47.
    发明授权
    Apparatus and methods for sample preparation 有权
    用于样品制备的装置和方法

    公开(公告)号：US07328628B2

    公开(公告)日：2008-02-12

    申请号：US11001988

    申请日：2004-12-02

    Applicant: James A. Laugharn, Jr. ,  Brevard S. Garrison

    Inventor： James A. Laugharn, Jr. ,  Brevard S. Garrison

    IPC: G01N1/38 ,  C12M1/33 ,  B01L3/00 ,  B02C19/18

    CPC classification number: C12M45/02 ,  B01L3/505 ,  B01L3/5082 ,  B01L3/50825 ,  B01L2300/123 ,  B01L2400/0481 ,  G01N1/286 ,  G01N2001/2866

    Abstract: The invention, in various embodiments, provides systems, methods and devices relating to processing a sample. A vessel is described for containing a sample. The vessel includes a reversibly sealable chamber for containing the sample which has a flexible portion to allow the vessel to deform nondestructively in response to a mechanical impact to fragment the sample. In certain embodiments the vessel may include a port for reversibly engaging with a second vessel to enable transfer of material between the two vessels while maintaining a barrier between the sample and an external environment. The vessel may be exposed to mechanical impacts of various energies and at various temperatures, and the internal surface of the structural barrier of the vessel may be treated with various chemical agents to maintain integrity of the sample.

    Abstract translation: 在各种实施例中，本发明提供了与处理样本有关的系统，方法和装置。 描述了一种用于容纳样品的容器。 容器包括可逆地密封的室，用于容纳具有柔性部分的样品，以允许容器响应于机械冲击而非破坏性地变形以将样品分段。 在某些实施例中，容器可以包括用于与第二容器可逆地接合的端口，以使得能够在两个容器之间转移材料，同时保持样品和外部环境之间的屏障。 容器可能暴露于各种能量和各种温度的机械冲击，容器的结构屏障的内表面可以用各种化学试剂处理以保持样品的完整性。

    Rapid cryobaric sterilization and vaccine preparation
    49.
    发明授权
    Rapid cryobaric sterilization and vaccine preparation 有权
    快速冷冻灭菌和疫苗制备

    公开(公告)号：US06696019B2

    公开(公告)日：2004-02-24

    申请号：US09924266

    申请日：2001-08-07

    Applicant: James A. Laugharn, Jr. ,  David W. Bradley ,  Robert A. Hess

    Inventor： James A. Laugharn, Jr. ,  David W. Bradley ,  Robert A. Hess

    IPC: A61L202

    CPC classification number: A61L2/02 ,  A23L3/0155 ,  A61L2/0011

    Abstract: The invention is based on the discovery that biological and non-biological materials can be sterilized, decontaminated, or disinfected by repeatedly cycling between relatively high and low pressures. Pressure cycling can be carried out at low, ambient, or elevated temperatures (e.g., from about −40° C. to about 95° C., or intermediate ranges). New methods based on this discovery can have applications in, for example, the preparation of vaccines, the sterilization of blood plasma or serum, plant, animal, and human tissue, sputum, urine, feces, water, and ascites, the decontamination of military devices, food and beverage production, and the disinfection of medical equipment. The new methods can also be incorporated into production processes or research procedures.

    Abstract translation: 本发明基于以下发现：生物和非生物材料可以通过在相对高和低的压力之间重复循环进行灭菌，去污或消毒。 压力循环可以在低，环境或升高的温度（例如，约-40℃至约95℃或中等范围）下进行。 基于该发现的新方法可以应用于例如疫苗的制备，血浆或血清，植物，动物和人体组织，痰液，尿液，粪便，水和腹水的灭菌，军事的去污 设备，食品和饮料生产以及医疗设备的消毒。 新的方法也可以纳入生产过程或研究程序。

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