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    Method and apparatus for headspace control in acoustic processing of samples
    1.
    发明授权
    Method and apparatus for headspace control in acoustic processing of samples 有权
    样品声学处理中顶空控制的方法和装置

    公开(公告)号：US08999704B2

    公开(公告)日：2015-04-07

    申请号：US13186858

    申请日：2011-07-20

    Applicant: James A. Laugharn, Jr.

    Inventor： James A. Laugharn, Jr.

    IPC: C12M1/33 ,  C12M3/08 ,  B01F11/02 ,  G01N1/28 ,  G01N35/00

    CPC classification number: C12N13/00 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N1/286 ,  G01N2035/00554

    Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

    Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。

    METHOD AND APPARATUS FOR HEADSPACE CONTROL IN ACOUSTIC PROCESSING OF SAMPLES
    2.
    发明申请
    METHOD AND APPARATUS FOR HEADSPACE CONTROL IN ACOUSTIC PROCESSING OF SAMPLES 有权
    方法和装置在样本的声学处理中的头部控制

    公开(公告)号：US20120015419A1

    公开(公告)日：2012-01-19

    申请号：US13186858

    申请日：2011-07-20

    Applicant: James A. Laugharn, JR.

    Inventor： James A. Laugharn, JR.

    IPC: C12N13/00 ,  C12M1/33

    CPC classification number: C12N13/00 ,  B01F11/0283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00486 ,  B01J2219/00722 ,  B01J2219/0074 ,  G01N1/286 ,  G01N2035/00554

    Abstract: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.

    Abstract translation: 用于控制包括液体的样品的声学处理的方法和装置。 可以例如通过定位合适的元件来控制样品进行声学处理的处理体积，以减少和/或消除样品/气体界面处的顶空尺寸。 可以例如通过使用至少部分定位在样品中的顶空控制元件来控制声能和样品之间的相互作用，所述顶空控制元件有助于减少否则会发生的飞溅或其它样品喷射。

    METHOD AND APPARATUS FOR MATERIAL SEPARATION USING ACOUSTIC ENERGY
    4.
    发明申请
    METHOD AND APPARATUS FOR MATERIAL SEPARATION USING ACOUSTIC ENERGY 有权
    使用声学能量的材料分离方法和装置

    公开(公告)号：US20100197894A1

    公开(公告)日：2010-08-05

    申请号：US12698599

    申请日：2010-02-02

    Applicant: James A. Laugharn, JR.

    Inventor： James A. Laugharn, JR.

    IPC: C07H21/04 ,  C07H21/02 ,  C07K1/22 ,  C07K16/00

    CPC classification number: C07K1/22 ,  B01D15/1807 ,  B01D15/3866 ,  C12N15/1006

    Abstract: A method and apparatus for exposing a sample, including a liquid and another material, to sonic energy to produce a desired result such as, suspending a material support in the liquid. The material support may be a bead or other particle with at least one surface feature to which the material may bind. Material in the liquid may attach to the material support, such as by specific or non-specific binding, entrapment or other, so as to facilitate separation of the material from the liquid. Separation of the material supports from the liquid and other unbound material may be done by allowing the material supports to settle out, e.g., under the force of gravity and/or as assisted by centrifugation, by applying a magnetic field in case the supports or material bound to the supports are movable by way of a magnetic field, or other techniques.

    Abstract translation: 一种用于将包括液体和另一种材料的样品暴露于声能以产生期望结果的方法和装置，例如将材料支撑物悬浮在液体中。 材料载体可以是具有材料可以结合的至少一个表面特征的珠粒或其它颗粒。 液体中的材料可以附着到材料载体上，例如通过特异性或非特异性结合，捕获或其它物质，以促进材料与液体的分离。 材料支撑物与液体和其它未结合材料的分离可以通过允许材料载体例如在重力作用下和/或通过离心辅助下沉积，通过在支撑物或材料的情况下施加磁场来进行 通过磁场或其他技术可以移动支撑件。

    Integrated sequencing device
    7.
    发明授权
    Integrated sequencing device 有权
    集成测序设备

    公开(公告)号：US06448065B2

    公开(公告)日：2002-09-10

    申请号：US09812262

    申请日：2001-03-19

    Applicant: James A. Laugharn, Jr. ,  Robert A. Hess

    Inventor： James A. Laugharn, Jr. ,  Robert A. Hess

    IPC: C12M134

    CPC classification number: C12Q1/37 ,  C12Q1/6874 ,  G01N33/6818 ,  G01N33/6848 ,  C12Q2527/109 ,  C12Q2537/149

    Abstract: The invention is based on the discovery that the sequence of monomers in a polymeric biomolecule can be determined in a self-contained, high pressure reaction and detection apparatus, without the need for fluid flow into or out from the apparatus. The pressure is used to control the activity of enzymes that digest the polymeric biomolecule to yield the individual monomers in the sequence in which they existed in the polymer. High pressures modulate enzyme kinetics by reversibly inhibiting those enzymatic processes which result in a higher average activation volume, when compared to the ground state, and reversibly accelerating those processes which have lower activation volumes than the ground state. Modulating the pressure allows the experimenter to precisely control the activity of the enzyme. Conditions can be found, for example, where the enzyme removes only one monomer (e.g., a nucleotide or amino acid) from the biomolecule before the pressure is again raised to a prohibitive level. The identity of the single released nucleotide or amino acid can be determined using a detector that is in communication with a probe in the detection zone within the reaction vessel.

    Abstract translation: 本发明基于以下发现：聚合物生物分子中的单体序列可以在独立的高压反应和检测装置中测定，而不需要流体流入或流出装置。 压力用于控制消化聚合物生物分子的酶的活性，以产生它们存在于聚合物中的序列中的各个单体。 高压通过可逆地抑制这些酶过程来调节酶动力学，其导致与基态相比更高的平均活化体积，并且可逆地加速具有比基态更低的活化体积的那些过程。 调节压力允许实验者精确控制酶的活性。 可以发现条件，例如，在再次将压力升至高水平之前酶仅从生物分子中除去一种单体（例如，核苷酸或氨基酸）的情况。 可以使用与反应容器内的检测区域中的探针连通的检测器来确定单个释放的核苷酸或氨基酸的身份。

    Acoustic treatment vessel and method for acoustic treatment
    9.
    发明授权
    Acoustic treatment vessel and method for acoustic treatment 有权
    声学处理容器和声学处理方法

    公开(公告)号：US09082393B2

    公开(公告)日：2015-07-14

    申请号：US13422086

    申请日：2012-03-16

    Applicant: James A. Laugharn, Jr. ,  Carl Beckett

    Inventor： James A. Laugharn, Jr. ,  Carl Beckett

    IPC: B01F11/02 ,  G10K11/28

    CPC classification number: A61B8/00 ,  B01F11/0258 ,  G10K11/28

    Abstract: Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.

    Abstract translation: 使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。 方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。 处理室可以包括诸如声窗和/或室壁的特征，其可以包括声反射材料或气体/壁界面，其用于反射声能以形成一个或多个次焦点区域。 提供了与处理室相对于声源和耦合介质，材料流动路径等的布置相关的处理系统配置。

    SYSTEMS AND METHODS FOR PREPARING NANOCRYSTALLINE COMPOSITIONS USING FOCUSED ACOUSTICS
    10.
    发明申请
    SYSTEMS AND METHODS FOR PREPARING NANOCRYSTALLINE COMPOSITIONS USING FOCUSED ACOUSTICS 审中-公开
    使用聚焦声学制备纳米晶体组合物的系统和方法

    公开(公告)号：US20130026669A1

    公开(公告)日：2013-01-31

    申请号：US13548384

    申请日：2012-07-13

    Applicant: Carl Beckett ,  James A. Laugharn, JR. ,  Srikanth Kakumanu

    Inventor： Carl Beckett ,  James A. Laugharn, JR. ,  Srikanth Kakumanu

    IPC: B29B9/12

    CPC classification number: C30B7/00 ,  B01F11/0241 ,  B01F11/0283 ,  B01F2215/0454 ,  C30B29/60

    Abstract: Methods and systems for preparing nanocrystalline compositions using focused acoustic processing to cause and/or enhance crystal growth. A flow through system may be employed to expose sample material having a volume of greater or less than 30 mL to focused acoustic energy while flowing through a process chamber at a rate of at least 0.1 mL/min. Sample material may be processed by a suitable focused acoustic field in a cyclic fashion and/or with adjustment of processing parameters based on monitored characteristics of the sample, such as level of crystallinity. Nanocrystalline particles within the sample may have a tight particle size distribution with an average particle size between 10 nm and 1 micron. Stable nanocrystalline compositions may be reproducibly prepared using focused acoustics to have controllable morphologies and dimensions.

    Abstract translation: 使用聚焦声学处理制备纳米晶体组合物以引起和/或增强晶体生长的方法和系统。 可以采用流通系统将具有大于或小于30mL的体积的样品材料暴露于聚焦的声能，同时以至少0.1mL / min的速率流过处理室。 样品材料可以通过合适的聚焦声场以循环方式和/或通过基于监测的样品特性（诸如结晶度的水平）调整加工参数进行处理。 样品内的纳米晶体颗粒可以具有紧密的粒度分布，平均粒度在10nm和1微米之间。 稳定的纳米晶体组合物可以使用聚焦声学重复地制备以具有可控的形态和尺寸。

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