DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION
    5.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION 审中-公开
    装置,系统和样品制备方法

    公开(公告)号:US20170022533A1

    公开(公告)日:2017-01-26

    申请号:US15140993

    申请日:2016-04-28

    Applicant: Theranos, Inc.

    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

    Abstract translation: 提供了包括用于样品制备的超声波发生器的装置,系统和方法。 超声波仪可用于混合,重悬,雾化,分散,分解或除气。 超声波仪器可用于破坏细胞,如样品中的病原体细胞。 样品制备可以包括通过超声处理暴露病原体识别材料以检测,鉴定或测量病原体。 超声波发生器可通过将其尖端接触到含有样品的容器的外壁将超声能量转移到样品溶液。 包括超声波发生器的多用途装置还包括用于附加动作和测定的其它组件。 设备和包括这种设备的系统可以与用于样品测定和分析的系统中的实验室或其他设备通信。 提供了利用这种装置和系统的方法。 改进的样品制备装置,系统和方法可用于分析样品,例如 用于诊断病原体感染的患者。

    DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION
    6.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION 审中-公开
    装置,系统和样品制备方法

    公开(公告)号:US20160266015A1

    公开(公告)日:2016-09-15

    申请号:US15140902

    申请日:2016-04-28

    Applicant: Theranos, Inc.

    Abstract: Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

    Abstract translation: 提供了包括用于样品制备的超声波发生器的装置,系统和方法。 超声波仪可用于混合,重悬,雾化,分散,分解或除气。 超声波仪器可用于破坏细胞,如样品中的病原体细胞。 样品制备可以包括通过超声处理暴露病原体识别材料以检测,鉴定或测量病原体。 超声波发生器可通过将其尖端接触到含有样品的容器的外壁将超声能量转移到样品溶液。 包括超声波发生器的多用途装置还包括用于附加动作和测定的其它组件。 设备和包括这种设备的系统可以与用于样品测定和分析的系统中的实验室或其他设备通信。 提供了利用这种装置和系统的方法。 改进的样品制备装置,系统和方法可用于分析样品,例如 用于诊断病原体感染的患者。

    EXTRACTION APPARATUS AND METHOD
    7.
    发明申请
    EXTRACTION APPARATUS AND METHOD 审中-公开
    提取装置和方法

    公开(公告)号:US20150219531A1

    公开(公告)日:2015-08-06

    申请号:US14424877

    申请日:2013-07-30

    Abstract: Disclosed is apparatus for distributing a solid, gel, powder or viscous test substance in an extraction fluid, the apparatus comprising a flow cell for holding the test substance and having an inlet and an outlet; an extraction chamber located between said inlet and outlet comprising a convergent nozzle; and a recirculating pump for driving extraction fluid: (i) into the flow cell via the inlet; (ii) through the extraction chamber; and (iii) back to the flow cell via the outlet, whereby a pressure differential is established across the extraction chamber such that the velocity of the extraction fluid is greater at the outlet than at the inlet; characterized in that the apparatus further comprises a tortuous path flow control valve (TPV) located at the outlet and configured to permit flow of extraction fluid and extracted test substance but to prevent or retard passage of said test substance through the outlet.

    Abstract translation: 公开了一种用于在提取液中分配固体,凝胶,粉末或粘性测试物质的装置,该装置包括用于保持测试物质并具有入口和出口的流动池; 位于所述入口和出口之间的提取室包括会聚喷嘴; 以及用于驱动萃取流体的循环泵:(i)经由所述入口流入所述流动池; (ii)通过提取室; 和(iii)经由出口返回到流动池,由此跨越提取室建立压差,使得提取流体在出口处的速度大于在入口处的速度; 其特征在于,该设备还包括位于出口处的曲折路径流量控制阀(TPV),其构造成允许提取流体和提取的测试物质流动,但是防止或阻止所述测试物质通过出口。

    METHOD OF SIMULTANEOUS CAVITATION TREATMENT OF LIQUID MEDIA DIFFERENT IN COMPOSITION
    8.
    发明申请
    METHOD OF SIMULTANEOUS CAVITATION TREATMENT OF LIQUID MEDIA DIFFERENT IN COMPOSITION 审中-公开
    液体不同组合物同时处理方法

    公开(公告)号:US20150217263A1

    公开(公告)日:2015-08-06

    申请号:US14454127

    申请日:2014-08-07

    Abstract: The present invention relates to a method of simultaneous cavitation treatment of liquid media having different compositions. The acoustic cavitation may operate by a double resonance effect inside a flow mechanical oscillatory system—formed as a rectangular channel of finite length. At opposing sides of which, the channel side walls generate in-phase sound oscillations. The interior of the mechanical oscillatory system rectangular channel further has additional flow channels therein to supply treated liquid media, the specific acoustic resistance of material of additional flow channels is close to the acoustic resistance of operating liquid. The width of the channel interior h is a multiple of a quarter of wavelength for the operating liquid at the frequency equal to the basic frequency of system-channel. The amplitude of system-channel wall oscillations creates a fully-developed acoustic cavitation mode over the entire inner volume of operating liquid including the flow channels liquid media therein.

    Abstract translation: 本发明涉及一种同时空化处理具有不同组成的液体介质的方法。 声空化可以通过形成为有限长度的矩形通道的流动机械振荡系统内的双重共振效应来操作。 在其相对的两侧,通道侧壁产生同相的声音振荡。 机械振荡系统矩形通道的内部还具有其中的附加流动通道以供应经处理的液体介质,附加流动通道的材料的特定声阻接近工作液体的声阻。 通道内部h的宽度是等于系统通道基本频率频率的工作液体的四分之一波长的倍数。 系统通道壁振荡的振幅在包括其中的流动通道液体介质的操作液体的整个内部体积上产生完全发展的声空化模式。

    SIMULTANEOUSLY AND ULTRASONICALLY INDUCED CAVITATION FLUID PROCESSING METHOD
    9.
    发明申请
    SIMULTANEOUSLY AND ULTRASONICALLY INDUCED CAVITATION FLUID PROCESSING METHOD 审中-公开
    同时和超声波诱导的流体加工方法

    公开(公告)号:US20150078114A1

    公开(公告)日:2015-03-19

    申请号:US14454066

    申请日:2014-08-07

    Abstract: A method and system for ultrasonically and simultaneously induced cavitation processing of fluid media-filled cells is provided. The method and system requires placing of cells in a bath filled with process fluid, wherein the fluid cell material exhibits specific acoustic resistance to be equal or close to that of the process fluid, sufficient acoustic wave amplitude is produced for specific process fluid so that well-developed acoustic cavitation occurs in process fluid and within every cell exposed to processing. The process fluid bath structure has a rectangular form where an acoustic standing wave is produced in the process fluid and is reflected from the bath walls and bottom. These walls and bottom may be designed as elastic membranes to have a self-resonant first harmonic frequency.

    Abstract translation: 提供了一种用于超声和同时诱导流体介质填充单元的空化处理的方法和系统。 该方法和系统需要将细胞置于填充有过程流体的浴中,其中流体细胞材料表现出与过程流体相同或接近的特定声阻,为特定的工艺流体产生足够的声波振幅, - 发达的声空化发生在工艺流体和暴露于加工的每个单元内。 过程流体浴结构具有矩形形式,其中在工艺流体中产生声驻波并从浴壁和底部反射。 这些壁和底部可以设计成弹性膜以具有自谐振的一次谐波频率。

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