公开(公告)号：US08170675B2

公开(公告)日：2012-05-01

申请号：US13245450

申请日：2011-09-26

Applicant: Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

Inventor： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

IPC: A61N1/18

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

Abstract: Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.

Abstract translation: 公开了选择性高频脊髓调制，用于抑制疼痛，减少副作用和相关系统和方法。 在特定实施例中，可以将大约1.5KHz至大约50KHz范围内的高频调制施加到患者的脊弦区域以解决腰背痛而不产生不想要的感觉和/或运动副作用。 在其他实施例中，根据类似参数的调制可以应用于其他脊柱或周边位置以解决其他指示。

公开(公告)号：US08065013B2

公开(公告)日：2011-11-22

申请号：US11746405

申请日：2007-05-09

Applicant: Kerry Bradley ,  James R. Thacker ,  Carla M. Woods ,  John D. King

Inventor： Kerry Bradley ,  James R. Thacker ,  Carla M. Woods ,  John D. King

IPC: A61N1/34

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  Y10S128/92

Abstract: A method of transitioning stimulation energy (e.g., electrical stimulation pulses) between a plurality of electrodes implanted within a patient is provided. The method comprises selecting a plurality of stimulation output values (e.g., electrical current amplitude values) for each of the electrodes. The method further comprises selecting a plurality of different modification values for at least one of the electrodes, respectively multiplying the stimulation output values and the modification values to determine modified stimulation output values for the electrode(s), which may optionally be stored in a steering table, and incrementally transitioning the stimulation energy to or from the electrode(s) in accordance with the modified stimulation output values. The modified stimulation output values are stored in a steering table. The modification values may be selected in a manner that maintains paresthesia when transitioning the stimulation energy between the electrodes.

Abstract translation: 提供了在植入患者体内的多个电极之间转换刺激能量（例如，电刺激脉冲）的方法。 该方法包括为每个电极选择多个刺激输出值（例如，电流振幅值）。 该方法还包括为至少一个电极选择多个不同的修改值，分别乘以刺激输出值和修改值，以确定电极的修改的刺激输出值，其可以可选地存储在转向 表，并且根据修改的刺激输出值逐渐地将刺激能量转移到电极或从电极移动。 经修改的刺激输出值存储在转向表中。 可以以在电极之间转换刺激能量时保持感觉异常的方式来选择修饰值。

公开(公告)号：US08036747B2

公开(公告)日：2011-10-11

申请号：US12506827

申请日：2009-07-21

Applicant: James R. Thacker ,  John D. H. King ,  Kerry Bradley

Inventor： James R. Thacker ,  John D. H. King ,  Kerry Bradley

IPC: A61N1/37

CPC classification number: A61N1/36071 ,  A61N1/0551

Abstract: A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

Abstract translation: 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

公开(公告)号：US20110060387A1

公开(公告)日：2011-03-10

申请号：US12946574

申请日：2010-11-15

Applicant: John D.H. King ,  James R. Thacker

Inventor： John D.H. King ,  James R. Thacker

IPC: A61N1/36

CPC classification number: A61N1/36139 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/3615

Abstract: A neural stimulation system automatically corrects or adjusts the stimulus magnitude (stimulation energy) in order to maintain a comfortable and effective stimulation therapy. Because the changes in impedance associated with the electrode-tissue interface can indicate obstruction of current flow and positional lead displacement, lead impedance can indicate the quantity of electrical stimulation energy that should be delivered to the target neural tissue to provide corrective adjustment. Hence, a change in impedance or morphology of an impedance curve may be used in a feedback loop to indicate that the stimulation energy needs to be adjusted and the system can effectively auto correct the magnitude of stimulation energy to maintain a desired therapeutic effect.

公开(公告)号：US07904162B2

公开(公告)日：2011-03-08

申请号：US11246719

申请日：2005-10-07

Applicant: Todd K Whitehurst ,  James P McGivern ,  Kelly H McClure ,  Goran N Marnfeldt ,  James R Thacker

Inventor： Todd K Whitehurst ,  James P McGivern ,  Kelly H McClure ,  Goran N Marnfeldt ,  James R Thacker

IPC: A61N1/08

CPC classification number: A61B5/413 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/41 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4244 ,  A61B2560/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61N1/30 ,  A61N1/32

Abstract: An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

Abstract translation: 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。

公开(公告)号：US07877137B2

公开(公告)日：2011-01-25

申请号：US11949752

申请日：2007-12-03

Applicant: Todd K Whitehurst ,  Kelly H McClure ,  James R Thacker

Inventor： Todd K Whitehurst ,  Kelly H McClure ,  James R Thacker

IPC: A61N1/08

CPC classification number: A61M5/14276 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2205/8243 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/30 ,  A61N1/362 ,  A61M2230/005

Abstract: Method and systems of treating a patient with at least one of a myocardial infarction, a stroke, and a pulmonary embolism include providing a stimulator coupled to at least one electrode and a catheter, configuring one or more stimulation parameters to treat at least one of a myocardial infarction, a stroke, and a pulmonary embolism, programming the stimulator with the one or more stimulation parameters, delivering with the stimulator via the catheter at least one drug to at least one tissue in accordance with the one or more stimulation parameters, and limiting perfusion of the at least one tissue by delivering electrical stimulation with the stimulator via the at least one electrode to the at least one tissue.

Abstract translation: 用心肌梗死，中风和肺栓塞中的至少一种治疗患者的方法和系统包括提供耦合到至少一个电极和导管的刺激器，配置一个或多个刺激参数以治疗下列中的至少一个： 心肌梗塞，中风和肺栓塞，用一个或多个刺激参数对刺激器进行编程，根据该一个或多个刺激参数，通过导管将至少一种药物通过导管递送至至少一个组织，并限制 通过将所述刺激器经由所述至少一个电极递送到所述至少一个组织的电刺激来灌注所述至少一个组织。

公开(公告)号：US07856277B1

公开(公告)日：2010-12-21

申请号：US11464137

申请日：2006-08-11

Applicant: James R. Thacker ,  Michael S Colvin ,  David K. L. Peterson ,  James P. McGivern

Inventor： James R. Thacker ,  Michael S Colvin ,  David K. L. Peterson ,  James P. McGivern

IPC: A61N1/372

CPC classification number: A61N1/0558 ,  A61M25/10

Abstract: An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.

Abstract translation: 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。

公开(公告)号：US07321794B2

公开(公告)日：2008-01-22

申请号：US10713511

申请日：2003-11-14

Applicant: James R Thacker ,  Kelly H McClure ,  Todd K Whitehurst ,  Philip H Lee

Inventor： James R Thacker ,  Kelly H McClure ,  Todd K Whitehurst ,  Philip H Lee

IPC: A61N1/368

CPC classification number: A61N1/3622

Abstract: An atrial, anti-arrhythmia system and method are provided. The system comprises: at least two electrodes attached to the atrium for providing independently controlled stimulus through each electrode; detection circuitry that can sense atrial fibrillation or the cardiac cycle; and stimulus generator that can deliver stimulation through at least two electrodes to stop atrial fibrillation. The method for treating atrial fibrillation has three possible modes: a first mode for detecting ongoing atrial fibrillation and stopping it; a second mode for detecting the cardiac cycle and delivering stimuli to the atrium after it has already begun to contract in order to suppress the onset of atrial fibrillation; and a third mode which applies pacing pulses to the atrium in a timed sequence to pace and contract the atrium faster than the native rate to preempt the initiation of atrial fibrillation.

Abstract translation: 提供心房，抗心律失常系统和方法。 该系统包括：至少两个连接到心房的电极，用于通过每个电极提供独立控制的刺激; 可以感测心房颤动或心动周期的检测电路; 和刺激发生器，其可以通过至少两个电极传递刺激以停止心房颤动。 治疗心房颤动的方法有三种可能的模式：用于检测持续性心房颤动并停止的第一种模式; 用于检测心脏周期并在其已经开始收缩之后向心房递送刺激以抑制心房颤动发生的第二模式; 以及第三种模式，其以定时序列将起搏脉搏应用于心房，以使起搏和收缩心房比天然速率更快地抢占心房颤动的开始。

公开(公告)号：US07263402B2

公开(公告)日：2007-08-28

申请号：US10212585

申请日：2002-08-05

Applicant: James R Thacker ,  John D King ,  Kerry Bradley

Inventor： James R Thacker ,  John D King ,  Kerry Bradley

IPC: A61N1/18

CPC classification number: A61N1/36071 ,  A61N1/0551

Abstract: A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

Abstract translation: 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

公开(公告)号：US06970741B1

公开(公告)日：2005-11-29

申请号：US10246554

申请日：2002-09-17

Applicant: Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

Inventor： Todd K. Whitehurst ,  James P. McGivern ,  Kelly H. McClure ,  Goran N. Marnfeldt ,  James R. Thacker

IPC: A61M5/00 ,  A61M5/142 ,  A61M5/172 ,  A61N1/00 ,  A61N1/30 ,  A61N1/32

CPC classification number: A61B5/413 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/41 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4244 ,  A61B2560/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61N1/30 ,  A61N1/32

Abstract: An implantable system control unit (SCU) includes means for measuring tissue impedance or other condition to determine allograft health, in order to predict or detect allograft rejection. The SCU also includes at least two electrodes coupled to means for delivering electrical stimulation to a patient within whom the device is implanted, and may also include a reservoir for holding one or more drugs and a driver means for delivering the drug(s) to the patient. In certain embodiments, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one SCU includes a sensor, and the sensed condition is used to adjust stimulation parameters. Alternatively, this sensory “SCU” sounds an alarm, communicates an alarm to an external device, and/or is responsive to queries regarding sensed information, such as tissue impedance.

Abstract translation: 可植入系统控制单元（SCU）包括用于测量组织阻抗或其他条件以确定同种异体移植物健康的装置，以便预测或检测同种异体移植排斥。 SCU还包括至少两个电极，其耦合到用于将电刺激递送到其中植入该装置的患者的装置，并且还可以包括用于容纳一种或多种药物的储存器和用于将药物递送至 患者。 在某些实施例中，系统能够进行开环和闭环操作。 在闭环操作中，至少一个SCU包括传感器，并且使用感测到的条件来调整刺激参数。 或者，该感官“SCU”发出警报，向外部设备通报警报，和/或响应关于感测信息（例如组织阻抗）的查询。