摘要:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where Ht, R2, T, and m are as described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要:
Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula: where A, B, R1, R2, T and Ht are described in the specification. The compounds are useful for treating diseases in mammals that are alleviated by a protein, kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要:
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.
摘要翻译:本文描述了可用作具有下式的蛋白激酶抑制剂的化合物:其中Z 1和Z 2各自独立地为氮或CH,环A,TmR 1,Q 2,R un R 3, 和Sp如说明书中所述。 该化合物特别可用作ERK2的抑制剂,并且用于治疗由蛋白激酶抑制剂,特别是癌症,炎性疾病,再狭窄,糖尿病和心血管疾病等疾病缓解的哺乳动物疾病。
摘要:
Disclosed are a method and/or a system of insurance rate optimization through driver behavior which includes a computer server of the driver monitoring environment to determine if a newly insured driver operating a private vehicle is adhering to a set of parameters set by an entity i.e. a driving school, an insurance provider and/or a family member of the newly insured driver. The system assigns a credit to the newly insured driver when it adheres to the set of parameters. The newly insured driver is monitored by the entity. A metadata is generated which includes a behavioral trait of the newly insured driver and an insurance rate is set through the insurance provider based on an adherence to the set of parameters set by the entity.
摘要:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
A device, system and method of data compression are provided. The invention includes a receiving module that may be a memory module. The invention also includes a pointer module storing a pointer to a location within the receiving module. The invention allocates a receiving space within the receiving module and associates the pointer with the receiving space. The pointer may be associated with the beginning of the receiving space. The invention compresses a first data block and directs the compressed first data block to the receiving space at the location indicated by the pointer. The invention further associates the pointer with the location in the receiving space contiguous with the received compressed first data block. The invention compresses a second data block and directs the compressed second data block to the location within the receiving space indicated by the pointer. The invention compresses data as contiguous compressed data blocks.
摘要:
Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要:
Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要翻译:本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐,其中环A,Z 1,Z 2,U,Q, R 1,R 2和L如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症(包括增殖性疾病如癌症)的严重性。
摘要:
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.