公开(公告)号：US20070055317A1

公开(公告)日：2007-03-08

申请号：US11220023

申请日：2005-09-06

Applicant: Jeffrey Stahmann ,  Joseph Pastore ,  Andrew Kramer ,  Rodney Salo ,  Jesse Hartley

Inventor： Jeffrey Stahmann ,  Joseph Pastore ,  Andrew Kramer ,  Rodney Salo ,  Jesse Hartley

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3684

Abstract: A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an intravascular pressure measurement in order to balance the beneficial effects of stress reduction with hemodynamic compromise.

Abstract translation: 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据血管内压力测量调节预激发起搏，以平衡应力减少与血液动力学妥协的有益效果。

公开(公告)号：US20070005114A1

公开(公告)日：2007-01-04

申请号：US11169339

申请日：2005-06-29

Applicant: Rodney Salo ,  Joseph Pastore ,  Jeffrey Stahmann ,  Jesse Hartley

Inventor： Rodney Salo ,  Joseph Pastore ,  Jeffrey Stahmann ,  Jesse Hartley

IPC: A61N1/00

CPC classification number: A61N1/36521 ,  A61N1/30

Abstract: A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.

Abstract translation: 一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路 和治疗电路。 控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

公开(公告)号：US20060287683A1

公开(公告)日：2006-12-21

申请号：US11276741

申请日：2006-03-13

Applicant: Joseph Pastore ,  Rodney Salo ,  Jesse Hartley ,  Andrew Kramer ,  Jeffrey Stahmann

Inventor： Joseph Pastore ,  Rodney Salo ,  Jesse Hartley ,  Andrew Kramer ,  Jeffrey Stahmann

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

Abstract: A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an assessment of cardiac function in order to balance the beneficial effects of stress reduction with hemodynamic compromise.

Abstract translation: 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据心脏功能的评估调节预激励起搏，以平衡应力减少与血液动力学妥协的有益效果。

公开(公告)号：US20050102000A1

公开(公告)日：2005-05-12

申请号：US10981019

申请日：2004-11-03

Applicant: Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

Inventor： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

IPC: A61N1/362 ,  A61N1/368 ,  A61N1/36

CPC classification number: A61N1/3627 ,  A61N1/3684

Abstract: A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

Abstract translation: 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

公开(公告)号：US20050043675A1

公开(公告)日：2005-02-24

申请号：US10645823

申请日：2003-08-21

Applicant: Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

Inventor： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC: A61B5/00 ,  A61B5/11 ,  A61M5/142 ,  A61M5/172 ,  A61M31/00 ,  A61N1/362

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

Abstract: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

Abstract translation: 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US06666826B2

公开(公告)日：2003-12-23

申请号：US10038936

申请日：2002-01-04

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61B502

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A body implantable system employs a lead system having at least one electrode and at least one pressure transducer at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The lead system includes an occlusion device at a distal end to occlude flow in the coronary vein. The pressure transducer is attached to a catheter that is disposed within an open lumen of the lead system. The pressure transducer senses a coronary vein pressure, the coronary vein pressure being proportional to the left ventricular pressure. The sensed coronary vein pressure gives indications of hemodynamic state of the left ventricle, and measured coronary vein pressure can be used to change a signal sent to the electrode to adaptively pace the patient's heart. The body implantable system can further utilize a right ventricular pressure measurement in concert with the left ventricular pressure measurement to modify pacing therapy parameters.

Abstract translation: 身体可植入系统采用在远端具有至少一个电极和至少一个压力换能器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 引导系统包括在远端处的阻塞装置以阻塞冠状静脉中的流动。 压力传感器连接到设置在引导系统的开口腔内的导管。 压力传感器感测冠状静脉压力，冠状静脉压力与左心室压力成比例。 感测到的冠状静脉压力给出了左心室的血液动力学状态的指示，并且可以使用测量的冠状静脉压力来改变发送到电极的信号，以适应性地调节患者的心脏。 身体可植入系统可以进一步利用与左心室压力测量一致的右心室压力测量来修改起搏治疗参数。

公开(公告)号：US07738967B2

公开(公告)日：2010-06-15

申请号：US11651311

申请日：2007-01-09

Applicant: Rodney Salo

Inventor： Rodney Salo

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

Abstract: Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

Abstract translation: 心脏起搏方法涉及感测左心室电节律，感测左心室血流速度，以及感测冠状静脉血液温度。 所述方法还包括至少部分地基于感测的冠状静脉血液温度和感测的左心室流率来修改同步电信号到患者心脏的传送。

公开(公告)号：US20080300643A1

公开(公告)日：2008-12-04

申请号：US12221332

申请日：2008-08-01

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/37

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: Pacing left and right ventricles of the heart for delivery of heart failure therapy involves measuring right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. At least one parameter of a heart failure pacing therapy is adjusted based on the parameter to improve synchronization of the right and left ventricles.

Abstract translation: 心脏左心室和右心室起搏用于心力衰竭治疗，用于测量右心室压（RV）压力和左心室压（LV）压力，并计算从RV和LV压力测量中的一个或两个发展的参数。 该参数表示左心室和右心室同步的程度。 基于参数调整心力衰竭起搏治疗的至少一个参数，以改善右心室和左心室的同步。

公开(公告)号：US07409244B2

公开(公告)日：2008-08-05

申请号：US10745031

申请日：2003-12-23

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A method and apparatus for pacing left and right ventricles of the heart involve measuring one or both of a right ventricular (RV) pressure and a left ventricular (LV) pressure, and computing a parameter developed from one or both of the RV and LV pressure measurements. The parameter is indicative of a degree of left and right ventricular synchronization. The parameter is assessed, and an interventricular (V-V) delay is adjusted in response to the parameter assessment. The V-V delay is adjusted to effect a change in the parameter that improves synchronization of the right and left ventricles. The computed parameter is a parameter indicative of hemodyamic state, such as a PP Loop or a pre-ejection period.

Abstract translation: 用于起搏心脏左心室和右心室的方法和装置包括测量右心室（RV）压力和左心室（LV）压力之一或两者，以及计算从RV和LV压力中的一个或两个所产生的参数 测量。 该参数表示左心室和右心室同步的程度。 评估参数，并根据参数评估调整室间（V-V）延迟。 调整V-V延迟以改变参数，改善右心室和左心室的同步。 所计算的参数是指示血液动力学状态的参数，例如PP环或预喷射期。

公开(公告)号：US20070239219A1

公开(公告)日：2007-10-11

申请号：US11278330

申请日：2006-03-31

Applicant: Rodney Salo ,  Guy Alvarez ,  Eric Lovett

Inventor： Rodney Salo ,  Guy Alvarez ,  Eric Lovett

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

Abstract: Described herein are methods and systems for delivering pacing therapy to HF patients who do not exhibit a reduced EF. Such patients do not have systolic dysfunction and generally do not benefit from established HF therapies that either augment contractile function or counteract conduction abnormalities. In one embodiment, a HF patient with a normal EF is tested for the adequacy of heart rate response during exercise. If the patient is found to be chronotropically incompetent, a rate-adaptive pacing mode is employed in order improve functional capacity.

Abstract translation: 本文描述的是用于向没有显示减少的EF的HF患者输送起搏治疗的方法和系统。 这些患者没有收缩功能障碍，一般不会从建立的HF疗法中获益，既可增强收缩功能，又可抵消传导异常。 在一个实施例中，测试具有正常EF的HF患者在运动期间心率反应的适当性。 如果发现患者是慢性不适的，则采用速率自适应起搏模式以提高功能能力。