公开(公告)号：US20060173505A1

公开(公告)日：2006-08-03

申请号：US11116955

申请日：2005-04-28

申请人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

发明人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus or papillary muscles in a manner that pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过在左心室的选定区域（例如在二尖瓣装置或乳头肌附近的区域）以在早期心室收缩期间预激活该区域的方式提供起搏刺激，可以获得有益效果，其可以预防或减少 二尖瓣反流的程度。

公开(公告)号：US20060217773A1

公开(公告)日：2006-09-28

申请号：US11088231

申请日：2005-03-23

申请人： Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

发明人： Qingsheng Zhu ,  Joseph Pastore ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20060173504A1

公开(公告)日：2006-08-03

申请号：US11046215

申请日：2005-01-28

申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

公开(公告)号：US20050102000A1

公开(公告)日：2005-05-12

申请号：US10981019

申请日：2004-11-03

申请人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

发明人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/36

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

摘要翻译： 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

公开(公告)号：US20080021508A1

公开(公告)日：2008-01-24

申请号：US11832552

申请日：2007-08-01

申请人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

摘要翻译： 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

公开(公告)号：US20080091138A1

公开(公告)日：2008-04-17

申请号：US11998969

申请日：2007-12-03

申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US20070260284A1

公开(公告)日：2007-11-08

申请号：US11381211

申请日：2006-05-02

申请人： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

发明人： Joseph Pastore ,  Tamara Baynham ,  Andrew Kramer ,  Julio Spinelli ,  Jeffrey Ross ,  Rodney Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/3956

摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。

公开(公告)号：US20060259088A1

公开(公告)日：2006-11-16

申请号：US11129058

申请日：2005-05-13

申请人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

发明人： Joseph Pastore ,  Andrew Kramer ,  Julio Spinelli ,  Rodney Salo ,  Tamara Baynham ,  Jeffrey Ross ,  Frits Prinzen ,  Ward Vanagt ,  Richard Cornelussen

IPC分类号： A61N1/362

CPC分类号： A61N1/056 ,  A61N1/3627 ,  A61N1/36557 ,  A61N1/37205 ,  A61N1/3787 ,  A61N2001/0585

摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.

公开(公告)号：US20060161209A1

公开(公告)日：2006-07-20

申请号：US11037309

申请日：2005-01-18

申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

IPC分类号： A61N1/362

CPC分类号： A61N1/365 ,  A61N1/36592

摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US20050256542A1

公开(公告)日：2005-11-17

申请号：US11184325

申请日：2005-07-19

申请人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph Pastore ,  Steven Girouard ,  Bruce KenKnight ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/3627 ,  A61N1/3684

摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

摘要翻译： 心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。 在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。