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公开(公告)号：US11838403B2
公开(公告)日：2023-12-05
申请号：US16845556
申请日：2020-04-10
Inventor： Alekhya Muthineni , Eugene John
CPC classification number: H04L9/0631 , G06F1/26
Abstract: The present techniques may provide improved processing and functionality of performance of the 128-bit AES Algorithm, which may provide improved power consumption. For example, in an embodiment, an encryption and decryption apparatus may comprise memory storing a current state matrix of an encryption or decryption process and a plurality of multiplexers configured to receive from the memory current elements of the state matrix stored in the memory, perform a cyclic shift on the received elements of the state matrix, and transmit the shifted elements to the memory for storage as a new state matrix.
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42.发明公开公开(公告)号：US20230349914A1
公开(公告)日：2023-11-02
申请号：US18029395
申请日：2021-09-30
Inventor： Tianshi LU , Tao WANG
CPC classification number: G01N33/6845 , G06N3/08 , G06N3/0455 , G16B40/20 , G16B15/30
Abstract: Neoantigens play a key role in the recognition of tumor cells by T cells. However, only a small proportion of neoantigens truly elicit T cell responses, and fewer clues exist as to which neoantigens are recognized by which T cell receptors (TCRs). To help determine the TCRs that interact with particular neoantigens, prediction models that predict TCR-binding specificities of neoantigens presented by different classes of major histocompatibility complex (MHCs) were developed. To confirm the applicability of the model to clinical settings, the prediction models were comprehensively validated by a series of analyses. The validated prediction models used a flexible transfer learning approach and differential learning schema to achieve highly accurate prediction of TCR binding specificity only using TCR sequence data, antigen sequence data, and MHC alleles.
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公开(公告)号：US20230338411A1
公开(公告)日：2023-10-26
申请号：US18312305
申请日：2023-05-04
Inventor： Mirko Hennig , Vladimir Kharitonov , Brandon A. Wustman , Jackson Eby , Rumpa Bhattacharjee , Daniel Siegwart
IPC: A61K31/7115 , A61K47/28 , A61K47/24 , A61K9/127 , A61K9/51
CPC classification number: A61K31/7115 , A61K9/1272 , A61K9/51 , A61K47/24 , A61K47/28
Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled to a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.
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公开(公告)号：US11795457B2
公开(公告)日：2023-10-24
申请号：US17486136
申请日：2021-09-27
Inventor： David Corey , Liande Li
IPC: C07H21/04 , C12N15/113 , A61P25/00 , A61K45/06
CPC classification number: C12N15/113 , A61K45/06 , A61P25/00 , C12N2310/14 , C12N2310/315 , C12N2310/3231
Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.
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公开(公告)号：US20230302138A1
公开(公告)日：2023-09-28
申请号：US18311616
申请日：2023-05-03
Inventor： Mirko Hennig , Vladimir Kharitonov , Brandon A. Wustman , Jackson Eby , Rumpa Bhattacharjee , Daniel Siegwart
CPC classification number: A61K47/543 , C12N15/113 , A61K47/544 , A61K47/10 , A61K47/28 , A61K9/0073 , A61P11/00
Abstract: Described herein are compositions, kits, and methods for potent delivery to a cell of a subject. The cell can be of a particular cell type, such as a basal cell, a ciliated cell, or a secretory cell. In some cases, the cell can be a lung cell of a particular cell type. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled to a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.
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Patent Agency Ranking
公开(公告)号：US20230301988A1
公开(公告)日：2023-09-28
申请号：US18023661
申请日：2021-08-26
Inventor： Thomas D. Meek , Chien-Te Tseng , Aleksandra Drelich , Drake M. Mellott
IPC: A61K31/495 , A61P31/14 , G01N33/569
CPC classification number: A61K31/495 , A61P31/14 , G01N33/56983 , G01N2333/165
Abstract: Provided herein are pharmaceutical compositions including compounds having Formula I (I) in an effective amount to inhibit non-viral cysteine protease (e.g., mammalian cysteine protease, such as human cathepsin L), as well as methods of using thereof.
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公开(公告)号：US20230235055A1
公开(公告)日：2023-07-27
申请号：US18007185
申请日：2021-07-26
Inventor： Zhiqiang AN , Chengcheng ZHANG , Ningyan ZHANG , Yuanzhi CHEN , Heyu CHEN
IPC: C07K16/28 , A61K45/06 , G01N33/574 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K45/06 , G01N33/57484 , A61K39/3955 , A61P35/00 , C07K2317/21 , C07K2317/24 , C07K2317/73 , A61K2039/505
Abstract: Provided herein are antibodies binding to LILRB1 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.
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公开(公告)号：US11690545B2
公开(公告)日：2023-07-04
申请号：US16357990
申请日：2019-03-19
Inventor： Christopher John Zahner
IPC: A61B5/15 , B01F13/00 , B01F11/00 , B01L3/00 , A61J1/05 , B01F31/60 , B01F33/301 , B01F101/23
CPC classification number: A61B5/150755 , A61B5/150022 , A61B5/150206 , A61B5/150343 , A61J1/05 , B01F31/60 , B01F33/3017 , B01L3/00 , B01F2101/23
Abstract: In one embodiment, a mixing device includes a sleeve that forms an inner space configured to receive a sample container, a housing associated with the sleeve, a mixing element contained within the housing that is configured to mix liquid contained within the sample container, and an activation element configured to activate the mixing element when the activation element is triggered.
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公开(公告)号：US11677071B2
公开(公告)日：2023-06-13
申请号：US16847909
申请日：2020-04-14
Applicant: National Technology & Engineering Solutions of Sandia, LLC , The Board of Regents of the University of Texas System
Inventor： Nelson S. Bell , Nancy A. Missert , Karen Lozano , Yatinkumar N. Rane
IPC: H01M4/04 , H01M4/131 , H01M4/13 , H01M4/505 , H01M4/525 , H01M4/36 , H01M4/1391 , H01M10/052 , H01M4/139 , H01M4/02
CPC classification number: H01M4/366 , H01M4/04 , H01M4/0471 , H01M4/13 , H01M4/131 , H01M4/139 , H01M4/1391 , H01M4/505 , H01M4/525 , H01M10/052 , H01M2004/021 , H01M2004/028
Abstract: A novel lithium battery cathode, a lithium ion battery using the same and processes and preparation thereof are disclosed. The battery cathode is formed by force spinning. Fiber spinning allows for the formation of core-shell materials using material chemistries that would be incompatible with prior spinning techniques. A fiber spinning apparatus for forming a coated fiber and a method of forming a coated fiber are also disclosed.
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公开(公告)号：US11666634B2
公开(公告)日：2023-06-06
申请号：US16858557
申请日：2020-04-24
Inventor： William T. Phillips
CPC classification number: A61K38/22 , A61K49/10 , A61K49/1815 , A61P1/00
Abstract: Described herein are methods of management of functional dyspepsia in a patient by administering an amylin analogue or a CCK composition to the patient. Methods of diagnosing such patient include a standard gastric-emptying assessment using a standardized solid meal along with measurements of blood glucose levels. Another method of diagnosing such patient includes a gastric-emptying scintigraphy assessment with labeled carbohydrates or other assessments to diagnose rapid carbohydrate gastric emptying.
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