公开(公告)号：US11174306B2

公开(公告)日：2021-11-16

申请号：US16343353

申请日：2017-10-19

Applicant: The Scripps Research Institute

Inventor： Travis S. Young ,  Leonard Presta ,  David Rodgers ,  Eric Hampton ,  Timothy Wright ,  Peter G. Schultz ,  Eduardo Laborda ,  Elvira Khialeeva ,  Sophie Viaud

IPC: C07K16/18 ,  A61P35/00 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  A61K39/00

Abstract: The present disclosure provides compositions, methods, kits, and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating disease and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.

公开(公告)号：US11135186B2

公开(公告)日：2021-10-05

申请号：US16066555

申请日：2016-12-29

Applicant: The Scripps Research Institute

Inventor： Christina Cooley ,  Jeffery W. Kelly ,  Ryan Paxman ,  Lars Plate ,  R. Luke Wiseman

IPC: A61K31/167 ,  A61K31/506 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/422 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/4245 ,  A61K31/47 ,  A61K31/4196 ,  A61K31/53 ,  A61K31/4178 ,  A61K31/137 ,  A61K31/50 ,  A61K31/4174 ,  A61K31/136 ,  A61K31/429 ,  A61K31/5377

Abstract: The invention provides compounds for activating the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR), or activating the transcriptional targets of ATF6, in the endoplasmic reticulum of a cell, the compounds being of any of formulas (I) through (IX) as described herein. The compounds can be used for treatment of conditions involving gain-of-toxic-function and loss-of-function folding disorders including lysosomal storage diseases, antitrypsin-associated emphysema and similar diseases. These molecules are also expected to have disease-ameliorating effects in Alzheimer's disease and diabetes.

公开(公告)号：US20210275664A1

公开(公告)日：2021-09-09

申请号：US17194834

申请日：2021-03-08

Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic ,  The Scripps Research Institute ,  Trustees of Dartmouth College

Inventor： Barney Graham ,  Jason McLellan ,  Andrew Ward ,  Robert Kirchdoerfer ,  Christopher Cottrell ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Nianshuang Wang ,  Jesper Pallesen ,  Hadi Yassine ,  Hannah Turner ,  Kizzmekia Corbett

IPC: A61K39/215 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

公开(公告)号：US20210261565A1

公开(公告)日：2021-08-26

申请号：US17246775

申请日：2021-05-03

Applicant: Purdue Research Foundation ,  The Scripps Research Institute

Inventor： Mingji Dai ,  Dexter Cameron Davis ,  Alexander Adibekian ,  Dominic Gregor Hoch ,  Zhong-Yin Zhang

IPC: C07D493/10

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers.

公开(公告)号：US20210255193A1

公开(公告)日：2021-08-19

申请号：US17139697

申请日：2020-12-31

Applicant: The Scripps Research Institute

Inventor： Benjamin F. CRAVATT ,  Stephan M. HACKER ,  Keriann M. BACKUS

IPC: G01N33/68 ,  C12N9/10 ,  G01N33/58 ,  G01N33/50 ,  C12N9/64

Abstract: Disclosed herein are methods and compounds for profiling a lysine reactive protein. Also described herein are methods, compounds, and compositions for identifying a small molecule fragment ligand that interacts with a reactive lysine residue.

公开(公告)号：US20210231659A1

公开(公告)日：2021-07-29

申请号：US17165718

申请日：2021-02-02

Applicant: Scripps Health ,  The Scripps Research Institute

Inventor： Darren SIGAL ,  Matthew MACAULEY

IPC: G01N33/569 ,  G01N33/574

Abstract: Myeloid derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells with the ability to mediate immunosuppression in cancer. Disclosed herein are methods of identifying MDSCs, methods of isolating MDSCs, and methods of treating patients.

公开(公告)号：US20210190783A1

公开(公告)日：2021-06-24

申请号：US16992232

申请日：2020-08-13

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Peter Kuhn ,  Dena Marrinucci

IPC: G01N33/574

Abstract: Methods are provided for detecting circulating tumor cells in a mammalian subject. Methods of diagnosing cancer in a mammalian subject are provided. The methods of detection or diagnosis indicate the presence of metastatic cancer or early stage cancer.

公开(公告)号：US11034691B2

公开(公告)日：2021-06-15

申请号：US16437007

申请日：2019-06-11

Applicant: The Scripps Research Institute

Inventor： Edward Roberts ,  Hugh Rosen ,  Mariangela Urbano ,  Miguel Guerrero

IPC: C07D471/04 ,  C07D239/26 ,  C07D213/78 ,  C07D241/42 ,  C07D249/08 ,  C07D263/32 ,  C07D271/10 ,  C07D413/14 ,  C07D213/38 ,  C07D213/55 ,  C07D213/61 ,  C07D213/75 ,  C07D213/80 ,  C07D215/12 ,  C07D217/18 ,  C07D235/14 ,  C07D237/08 ,  C07D239/30 ,  C09B55/00 ,  C07D213/40 ,  C07D211/16 ,  C07D285/12 ,  C07D271/06 ,  C07D413/12 ,  C07D413/06 ,  C07D413/04 ,  C07D409/12 ,  C07D405/12 ,  C07D405/06 ,  C07D401/12 ,  C07D333/20 ,  C07D309/14 ,  C07D309/06 ,  C07D241/16 ,  C07D263/58 ,  C07C255/63

Abstract: The invention provides compounds effective as sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.

公开(公告)号：US20210128720A1

公开(公告)日：2021-05-06

申请号：US16071199

申请日：2017-01-18

Applicant: THE SCRIPPS RESEARCH INSTITUTE

Inventor： Kim D. Janda

IPC: A61K39/385 ,  A61K47/68 ,  A61K47/64 ,  A61K39/395 ,  A61K39/00 ,  A61P25/30

Abstract: Fentanyl is an addictive prescription opioid that is over 80 times mora potent than morphine. The synthetic nature of fentanyl has enabled the creation of dangerous “designer drug’ analogues that escape toxicology screening, yet display comparable potency to the parent drug. Alarmingly, a large number of fatalities have been linked to overdose of fentanyl derivatives. Herein, we report an effective immunotherapy for reducing the psychoactive effects of fentanyl class drugs. A single conjugate vaccine was created that elicited high levels of antibodies with cross-reactivity for a wide panel of fentanyl analogues, Moreover, vaccinated mice gained significant protection from lethal fentanyl doses. Lastly, a surface plasmon resonance (SPR)-based technique was established enabling drug specificity profiling of antibodies derived directly from serum. Our newly developed fentanyl vaccine and analytical methods may assist in the battle against synthetic opioid abuse.

公开(公告)号：US10995366B2

公开(公告)日：2021-05-04

申请号：US15367015

申请日：2016-12-01

Applicant: MINDERA CORPORATION ,  The Scripps Research Institute

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/6841 ,  A61K9/00 ,  C12Q1/6806 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1468 ,  A61B10/02 ,  A61B10/00 ,  C12Q1/6837 ,  C12Q1/6876 ,  G01N1/08 ,  A61B5/00

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).