公开(公告)号：US20230383352A1

公开(公告)日：2023-11-30

申请号：US18317841

申请日：2023-05-15

Applicant: MiNDERA Corporation

Inventor： Tobin DICKERSON ,  Bradford TAFT ,  Byung-In LEE

IPC: C12Q1/6883 ,  C12Q1/6869 ,  G16B20/00 ,  G16B40/20 ,  A61M37/00

CPC classification number: C12Q1/6883 ,  C12Q1/6869 ,  G16B20/00 ,  G16B40/20 ,  A61M37/0015 ,  C12Q2600/158 ,  C12Q2600/106 ,  A61M2037/0023

Abstract: The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired characteristics Such methods greatly simplify and reduce the time necessary to carry out previously-known procedures, and offers new approaches as well, such as selecting cells that generate a particular protein or antisense oligonucleotide, generating cell lines that express multiple proteins, generating cell lines with knock-out of one or more protein, and others.

公开(公告)号：US20170145489A1

公开(公告)日：2017-05-25

申请号：US15367015

申请日：2016-12-01

Applicant: MINDERA CORPORATION ,  The Scripps Research Institute

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/68 ,  A61B5/145 ,  G01N1/08

CPC classification number: C12Q1/6841 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/1468 ,  A61B5/150015 ,  A61B5/150022 ,  A61B5/150984 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0233 ,  A61B2010/008 ,  A61B2562/046 ,  A61K9/0021 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N1/08 ,  C12Q2531/113 ,  C12Q2565/501 ,  C12Q2565/607 ,  C12Q2565/629 ,  C12Q2543/101

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

公开(公告)号：US20210317513A1

公开(公告)日：2021-10-14

申请号：US17175606

申请日：2021-02-12

Applicant: MINDERA CORPORATION ,  The Scripps Research Institute

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/6841 ,  A61K9/00 ,  C12Q1/6806 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1468 ,  A61B10/02 ,  A61B10/00 ,  C12Q1/6837 ,  C12Q1/6876 ,  G01N1/08

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

公开(公告)号：US09540684B2

公开(公告)日：2017-01-10

申请号：US14106661

申请日：2013-12-13

Applicant: MINDERA Corporation ,  The Scripps Research Institute

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/68 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1468 ,  A61K9/00 ,  A61B5/00

CPC classification number: C12Q1/6841 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/1468 ,  A61B5/150015 ,  A61B5/150022 ,  A61B5/150984 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0233 ,  A61B2010/008 ,  A61B2562/046 ,  A61K9/0021 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N1/08 ,  C12Q2531/113 ,  C12Q2565/501 ,  C12Q2565/607 ,  C12Q2565/629 ,  C12Q2543/101

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Abstract translation: 本发明提供了用于从原位原位检测和捕获分子生物标志物的装置和方法。 具体地，这些装置包含一组微针，其上附着有针对感兴趣的一种或多种生物标志物的探针。 在检测受试者体内的生物标志（例如，组织，血液）中时，这些装置可以直接用于受试者（例如通过皮肤刺穿）。

公开(公告)号：US20240425926A1

公开(公告)日：2024-12-26

申请号：US18812671

申请日：2024-08-22

Applicant: MiNDERA Corporation

Inventor： Tobin DICKERSON ,  Bradford TAFT ,  Byung-In LEE

IPC: C12Q1/6883 ,  A61M37/00

Abstract: The present disclosure provides microneedle devices and kits for extracting biomarkers from a tissue. The present disclosure provides microneedle-device-mediated extraction methods for extracting biomarkers from a lesional skin of a subject. The present disclosure also provides computer-implemented methods for predicting a patient's response to an autoimmune therapeutic drug. The present disclosure provides methods selecting a treatment for an autoimmune disease. The present disclosure also provides methods of nucleic acid analysis to prospectively predict a patient's response to a therapeutic.

公开(公告)号：US10995366B2

公开(公告)日：2021-05-04

申请号：US15367015

申请日：2016-12-01

Applicant: MINDERA CORPORATION ,  The Scripps Research Institute

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/6841 ,  A61K9/00 ,  C12Q1/6806 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1468 ,  A61B10/02 ,  A61B10/00 ,  C12Q1/6837 ,  C12Q1/6876 ,  G01N1/08 ,  A61B5/00

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

公开(公告)号：US20140287942A1

公开(公告)日：2014-09-25

申请号：US14106661

申请日：2013-12-13

Applicant: The Scripps Research Institute ,  MINDERA Corporation

Inventor： Tahir A. Mahmood ,  Tobin J. Dickerson ,  Nadir A. Mahmood ,  Petr Capek

IPC: C12Q1/68

CPC classification number: C12Q1/6841 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/1468 ,  A61B5/150015 ,  A61B5/150022 ,  A61B5/150984 ,  A61B5/685 ,  A61B10/0045 ,  A61B10/0233 ,  A61B2010/008 ,  A61B2562/046 ,  A61K9/0021 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2600/16 ,  G01N1/08 ,  C12Q2531/113 ,  C12Q2565/501 ,  C12Q2565/607 ,  C12Q2565/629 ,  C12Q2543/101

Abstract: The present invention provides devices and methods for detecting and capturing molecular biomarkers from a subject in situ. Specifically, the devices contain an array of microneedles to which are attached probes specific for one or more biomarkers of interest. The devices can be used directly on a subject (e.g., via skin piercing) in detecting the biomarkers in the body of the subject (e.g., tissues, blood stream).

Abstract translation: 本发明提供了用于从原位原位检测和捕获分子生物标志物的装置和方法。 具体地，这些装置包含一组微针，其上附着有针对感兴趣的一种或多种生物标志物的探针。 在检测受试者体内的生物标志（例如，组织，血液）中时，这些装置可以直接用于受试者（例如通过皮肤刺穿）。