公开(公告)号：US20240175790A1

公开(公告)日：2024-05-30

申请号：US18196402

申请日：2023-05-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Garry P. Nolan ,  Yunhao Bai ,  Bokai Zhu ,  Xavier Rovira Clave ,  Sizun Jiang

IPC分类号： G01N1/30

CPC分类号： G01N1/30

摘要： Provided herein is a method for processing a tissue sample. The method may comprise: (a) permeating the tissue section with monomers for a negatively charged expandible gel, (b) allowing the monomers to polymerize in the tissue sample, (c) hydrating the tissue sample, thereby causing the sample to expand, (d) adhering expanded tissue sample to a positively charged surface and (e) dehydrating the expanded tissue sample while it is on the planar surface.

公开(公告)号：US11993645B2

公开(公告)日：2024-05-28

申请号：US16476501

申请日：2018-01-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Vincent Christopher Luca ,  Kenan Christopher Garcia

IPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/54 ,  C07K14/55

CPC分类号： C07K16/18 ,  C07K14/5406 ,  C07K14/55 ,  A61K38/00 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2319/21 ,  C07K2319/81

摘要： R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.

公开(公告)号：US11992630B2

公开(公告)日：2024-05-28

申请号：US17001569

申请日：2020-08-24

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Craig Comiter ,  Gabe Ho ,  Maria Iglesias ,  Isaac Justice ,  Amanda Urke

IPC分类号： A61M25/01 ,  A61M25/00

CPC分类号： A61M25/0116 ,  A61M25/0017 ,  A61M25/01 ,  A61M2210/1085 ,  A61M2210/1089

摘要： Devices and methods are provided to facilitate self-catheterization of a urethra. In an exemplary embodiment, the device includes an elongate anchor member comprising a proximal end and a rounded distal end to facilitate insertion into a user's vagina, a bridge extending laterally from an intermediate location of the anchor member, a guide on the bridge spaced apart from the anchor member such that the guide is aligned with the user's urethra, the guide including a passage therethrough sized to receive a urinary catheter therethrough, and a handle on the proximal end of the anchor member to facilitate manipulation by the user and consistent, accurate alignment of the guide.

公开(公告)号：US20240165268A1

公开(公告)日：2024-05-23

申请号：US18420397

申请日：2024-01-23

申请人： University of Miami ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Michael S. KAPILOFF ,  Jinliang LI

IPC分类号： A61K48/00 ,  A61K35/761 ,  A61P9/04

CPC分类号： A61K48/0066 ,  A61K35/761 ,  A61P9/04

摘要： The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAPβ. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAPβ to which PP2A binds.

公开(公告)号：US11979028B2

公开(公告)日：2024-05-07

申请号：US17486323

申请日：2021-09-27

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： Daniel M. Pivonka ,  Anatoly Anatolievich Yakovlev ,  Ada Shuk Yan Poon ,  Teresa H. Meng

IPC分类号： A61M25/01 ,  A61B1/00 ,  A61B5/07 ,  A61M31/00 ,  H02J50/10 ,  H02J50/23 ,  H02J50/27 ,  H02J50/80 ,  H02J50/90 ,  H02J7/34

CPC分类号： H02J50/10 ,  A61B1/00158 ,  A61B5/07 ,  A61M25/0116 ,  A61M25/0127 ,  A61M31/002 ,  H02J50/23 ,  H02J50/27 ,  H02J50/80 ,  H02J50/90 ,  H02J7/345 ,  H02J2310/23

摘要： Described is a locomotive implant for usage within a predetermined magnetic field. In one embodiment magnetohydrodynamics is used to generate thrust with a plurality of electrodes. In another embodiment, asymmetric drag forces are used to generate thrust.

公开(公告)号：US11975123B2

公开(公告)日：2024-05-07

申请号：US16590189

申请日：2019-10-01

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Eric Andrew Appel ,  Y. Joseph Woo ,  Lyndsay Stapleton

IPC分类号： A61L31/04 ,  A61L31/14 ,  C08L1/08 ,  C08L67/02

CPC分类号： A61L31/041 ,  A61L31/042 ,  A61L31/145 ,  A61L31/148 ,  C08L1/08 ,  C08L67/025 ,  A61L2300/424 ,  A61L2400/06 ,  C08L2203/02 ,  C08L2205/22

摘要： A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

公开(公告)号：US11969433B2

公开(公告)日：2024-04-30

申请号：US16548531

申请日：2019-08-22

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Helen M. Blau ,  Andrew Tri Van Ho ,  Adelaida R. Palla

IPC分类号： A61K35/34 ,  A61K31/5575 ,  C12N5/077 ,  A61P9/10 ,  A61P21/00

CPC分类号： A61K31/5575 ,  A61K35/34 ,  C12N5/0658 ,  A61P9/10 ,  A61P21/00 ,  C12N2501/02 ,  A61K35/34 ,  A61K2300/00 ,  A61K31/5575 ,  A61K2300/00

摘要： Provided herein are compositions, methods, and kits for proliferating muscle cells by exposing the muscle cells to a prostaglandin E2 (PGE2) compound or compound that activates PGE2 signaling. Also provided are methods for regenerating muscle in a subject suffering from muscular atrophy, dystrophy, and/or injury by administering a PGE2 compound alone or in combination with isolated muscle cells. The PGE2 compound in combination with the isolated muscle cells can be administered prophylactically to prevent a muscle disease or condition.

公开(公告)号：US20240133027A1

公开(公告)日：2024-04-25

申请号：US18487543

申请日：2023-10-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Srabanti Chowdhury ,  Kwangjae Lee

IPC分类号： C23C16/30 ,  C23C16/02 ,  C23C16/04

CPC分类号： C23C16/303 ,  C23C16/0227 ,  C23C16/045

摘要： Improved fabrication is provided for devices in the GaN material system that require an embedded p-type layer. The effect of Mg diffusion from the p-type layer is compensated for using an GaN interlayer that is etched to be nanoporous at its top surface. In addition to serving as a diffusion barrier, the GaN interlayer preferably has C and O impurities from the etch that tend to compensate unwanted Mg doping in layers above the GaN interlayer. Importantly, the entire structure can be grown at high temperatures, which desirably avoids low temperature growth steps that tend to reduce material quality.

公开(公告)号：US11961837B2

公开(公告)日：2024-04-16

申请号：US17571128

申请日：2022-01-07

申请人： The Board of Trustees of the Leland Stanford Junior University ,  The Regents of the University of California

发明人： Srabanti Chowdhury ,  Mohamadali Malakoutian ,  Matthew A. Laurent ,  Chenhao Ren ,  Siwei Li

IPC分类号： H01L27/085 ,  H01L21/02 ,  H01L21/8258 ,  H01L23/00 ,  H01L23/373 ,  H01L29/16 ,  H01L29/20

CPC分类号： H01L27/085 ,  H01L21/02389 ,  H01L21/02527 ,  H01L21/02595 ,  H01L21/0262 ,  H01L21/8258 ,  H01L23/3732 ,  H01L24/80 ,  H01L29/1602 ,  H01L29/2003 ,  H01L2224/80203 ,  H01L2924/13064 ,  H01L2924/13091

摘要： In certain examples, methods and semiconductor structures are directed to an integrated circuit (IC) having a diamond layer section and a GaN-based substrate being monolithically integrated or bonded as part of the same IC. In a specific example, the GaN-based substrate includes GaN, AlxGayN (0

公开(公告)号：US20240117096A1

公开(公告)日：2024-04-11

申请号：US18221998

申请日：2023-07-14

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Yu Zheng ,  Zhenan Bao

IPC分类号： C08F283/00 ,  H10K10/46 ,  H10K85/10

CPC分类号： C08F283/00 ,  H10K10/46 ,  H10K85/113 ,  H10K85/151

摘要： Aspects involve a stretchable composite film including a polymer material having at least a portion of the polymer material being densified through covalently-attached fluorination molecules. In certain specific examples, fluorinated molecules are covalently attached to a surface region, in the form of a layer or film (e.g., polymer semiconductor (PSC) film of a transistor substrate) to facilitate operational stability and/or to encapsulation performance (e.g., stretchability-related performance). In certain other specific examples, the surface region and a fluorinated layer are used in a cooperative configuration to provide stability in the PSC film in one or more harsh environments characterized by one or more of humid air, and immersion of the PSC film in a bio-based fluid.