公开(公告)号：US20200222709A1

公开(公告)日：2020-07-16

申请号：US16739650

申请日：2020-01-10

申请人： University of Maryland, Baltimore ,  University of Maryland, Baltimore County

发明人： L. Elliot Hong ,  Fow-Sen Choa ,  Qinglei Meng

IPC分类号： A61N2/02 ,  H01F7/20 ,  H01F27/28 ,  H01F27/255 ,  A61N2/00

摘要： Disclosed is an electromagnetic coil system for use during transcranial or transdermal stimulation procedures, in which an electrically conductive coil wraps around a magnetic core at an oblique wrapping angle to provide a more directed focal spot size at a given depth inside of, for example, a patient's body. In certain configurations, the electrically conductive coil may be adjustable with respect to the magnetic core, such that the wrapping angle of the electrically conductive coil may be modified to, in turn, adjust the focal spot size of the induced electric field generated by the system as may desired to concentrate the field at a particularly desired location.

公开(公告)号：US20190160092A1

公开(公告)日：2019-05-30

申请号：US16195770

申请日：2018-11-19

申请人： University of Maryland, Baltimore ,  University of Maryland, College Park

发明人： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC分类号： A61K31/722 ,  A61K47/56 ,  A61K9/70 ,  A61K47/61 ,  A61K47/69 ,  A61K9/127 ,  A61L27/20 ,  A61L26/00

摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

公开(公告)号：US10130625B2

公开(公告)日：2018-11-20

申请号：US15327485

申请日：2015-07-22

申请人： University of Maryland, College Park ,  University of Maryland, Baltimore

发明人： Herman O. Sintim ,  Jie Zhou ,  Changhao Wang ,  Rena Lapidus

IPC分类号： A61K31/472 ,  A61K31/4725 ,  C07C257/18 ,  C07C245/24 ,  C07D217/22 ,  C07D401/12 ,  C07D413/12 ,  C07D401/04 ,  C07D471/04

摘要： Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.

公开(公告)号：US20180193658A1

公开(公告)日：2018-07-12

申请号：US15740175

申请日：2016-06-29

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： Liyi Elliott HONG ,  Fow-Sen CHOA

IPC分类号： A61N2/02 ,  A61N2/00 ,  A61N2/06 ,  A61N2/12

CPC分类号： A61N2/02 ,  A61N2/006 ,  A61N2/06 ,  A61N2/12

摘要： Methods and systems to control magnetic fields and magnetic field induced currents, and to provide stimulations within a patient's body, e.g.: deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. An array of magnetic coils is provided and positionable about a portion of a patient's body, and are configured to create a small region of a magnetic hole, or configured to create a small region of concentrated magnetic field strength, or their combination, and at depths within the patient's body in a focused region and sparing the surrounding tissues of the focused region, that have previously not been receptive to non-invasive TMS methods, which are either focused but can affect only the surface and shadow areas, or that can reach certain depths but by doing so only through affecting large surface areas and deep tissue areas.

公开(公告)号：US20180190388A1

公开(公告)日：2018-07-05

申请号：US15736939

申请日：2016-06-15

申请人： University of Maryland, Baltimore ,  University of Maryland Faculty Physicians, Inc.

发明人： Reuben Mezrich ,  Wayne LaBelle

IPC分类号： G16H80/00 ,  H04N7/15 ,  G09G5/14 ,  G06F3/14 ,  G06F3/01

CPC分类号： G16H80/00 ,  G06F3/012 ,  G06F3/0487 ,  G06F3/14 ,  G06F3/1454 ,  G06F3/1462 ,  G09G5/14 ,  G09G2354/00 ,  G16H40/63 ,  G16H40/67 ,  H04N7/15 ,  H04N13/117 ,  H04N13/344

摘要： A method and apparatus are provided for enhancing a navigational efficiency of a virtual workstation. The method includes receiving a design space describing a desired arrangement of virtual monitors. The method further includes receiving data associated with head movement of a user wearing a virtual reality headset. The method further includes determining a movement of a view space over the design space where the view space encompasses only a portion of the design space. The view space movement is based on the head movement such that a ratio of the view space movement to the head movement is in a range comprising values other than unity. The method also includes moving the view space based on the determined movement of the view space and presenting on the virtual reality headset the portion of the design space within the view space.

公开(公告)号：US09133114B2

公开(公告)日：2015-09-15

申请号：US13752482

申请日：2013-01-29

申请人： UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY OF MARYLAND, COLLEGE PARK

发明人： Yihua (Bruce) Yu ,  Xuyi Yue

IPC分类号： A61K51/06 ,  C07C323/12 ,  A61K49/12

CPC分类号： C07C323/12 ,  A61K49/124 ,  A61K51/06

摘要： The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.

摘要翻译： 本发明提供了具有核心，分支和周边末端的单分散树枝状大分子，其中分支数目从核心到周边端呈指数级增加，并且分支的长度从周边端到核心指数地增加，从而提供附着 的化学物质在周边端部没有表现出空间位阻。

公开(公告)号：US20150175714A1

公开(公告)日：2015-06-25

申请号：US14595551

申请日：2015-01-13

申请人： University of Maryland, Baltimore ,  University of Maryland, College Park

发明人： Matthew Dowling ,  John Hess ,  Grant Bochicchio ,  Srinivasa Raghavan

IPC分类号： C08B15/00

摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

公开(公告)号：US20140043618A1

公开(公告)日：2014-02-13

申请号：US13962450

申请日：2013-08-08

申请人： University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs ,  St. Jude Medical ,  University of Maryland, College Park

发明人： Cha-Min Tang ,  Chia-Pin Liang ,  Yu Chen ,  Ashraf Fouad ,  Joseph Schmitt ,  Nicholas Woolsey

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/0261 ,  A61B5/489 ,  A61B5/7415 ,  A61C19/04

摘要： A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates motion in a target volume of a sample in a vicinity of the probe tips based on a Doppler shift of the scattered light. The volume depends on coherence distance determined by the bandwidth. In variations, the first and second tips are the same tip, a multimode fiber is included, the bandwidth is between 0.1% and 5% of a center wavelength, or the presentation device is a speaker, or some combination.

摘要翻译： 适用于医疗程序的运动传感器包括具有波长带宽的光源和光学检测器。 第一光耦合器终止于第一探针尖端并将光耦合到第一探针尖端中。 第二光耦合器终止于第二探针尖端并且引导到检测器通过第二探针尖端返回的散射光。 呈现装置基于散射光的多普勒频移输出指示探针尖端附近的样本的目标体积中的运动的信号。 音量取决于带宽确定的相干距离。 在变型中，第一和第二尖端是相同的尖端，包括多模光纤，带宽在中心波长的0.1％至5％之间，或者呈现装置是扬声器或某种组合。

公开(公告)号：US20240033082A1

公开(公告)日：2024-02-01

申请号：US17816080

申请日：2022-07-29

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC

发明人： James Gammie ,  Rachael Quinn ,  Chetan Pasrija

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2454 ,  A61F2/2463

摘要： The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.

公开(公告)号：US11872133B1

公开(公告)日：2024-01-16

申请号：US17816080

申请日：2022-07-29

申请人： University of Maryland, Baltimore ,  University of Maryland Medical System LLC

发明人： James Gammie ,  Rachael Quinn ,  Chetan Pasrija

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2454 ,  A61F2/2463

摘要： The present invention provides devices for treating functional mitral regurgitation and methods of use thereof. The devices translocate a subject's mitral valve in an apical direction. The devices thereby treat mitral regurgitation while preserving a subject's original mitral valve and chordae tendinae.