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41.发明授权Nucleic acid and corresponding protein named 158P1D7 useful in the treatment and detection of bladder and other cancers 有权核酸和相应的名为158P1D7的蛋白质可用于膀胱癌和其他癌症的治疗和检测公开(公告)号：US07358353B2
公开(公告)日：2008-04-15
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
发明人： Aya Jakobovits , Robert Kendall Morrison , Arthur B. Raitano , Pia M. Challita-Eid , Juan J. Perez-Villar , Karen Jane Meyrick Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven B. Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（称为158P1D7）及其编码的蛋白质。 虽然158P1D7在正常成人组织中表现出组织特异性表达，但在多种癌症中异常表达，包括表1所示。因此，158P1D7为癌症提供诊断和/或治疗靶标。 158P1D7基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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42.发明申请Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer 有权核酸和相应的蛋白质98P4B6可用于治疗和检测癌症公开(公告)号：US20070253900A1
公开(公告)日：2007-11-01
申请号：US11588203
申请日：2006-10-25
申请人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
发明人： Arthur Raitano , Wangmao Ge , Aya Jakobovits , Pia Challita-Eid , Mary Faris
IPC分类号： A61K38/00 , A01K67/00 , A61K31/395 , A61K39/00 , A61K49/00 , A61K51/10 , C07H21/04 , C07K7/00 , C12Q1/68 , G01N33/574 , G01N33/567 , G01N33/53 , C12N5/12 , C07K14/00 , C07H21/02 , A61K49/16 , A61K39/44 , A61K31/7088 , A61K35/12
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K16/3069 , C07K2319/00 , C07K2319/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16 , G01N33/574
摘要： A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因098P4B6（也称为STEAP-2）及其编码的蛋白及其变体，其中98P4B6在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，98P4B6提供 诊断，预后，预防和/或治疗靶标。 98P4B6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与98P4B6反应的抗体或T细胞可用于主动或被动免疫。
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43.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 251P5G2 USEFUL IN TREATMENT AND DETECTION OF CANCER 有权核酸和相关蛋白质251P5G2可用于治疗和检测癌症公开(公告)号：US20070231261A1
公开(公告)日：2007-10-04
申请号：US11549900
申请日：2006-10-16
申请人： Arthur Raitano , Pia Challita-Eid , Aya Jakobovits , Mary Faris , Wangmao Ge
发明人： Arthur Raitano , Pia Challita-Eid , Aya Jakobovits , Mary Faris , Wangmao Ge
IPC分类号： A61K38/00 , A61K31/70 , A61K38/43 , A61K39/00 , A61K39/395 , C07H21/04 , C07K14/00 , C12N5/06 , C12Q1/68 , G01N33/53
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 251P5G2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 251P5G2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 251P5G2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因251P5G2及其编码的蛋白及其变体，其中251P5G2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，251P5G2提供诊断，预后，预防和/ 或癌症的治疗靶标。 251P5G2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与251P5G2反应的抗体或T细胞可用于主动或被动免疫。
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44.发明授权公开(公告)号：US07244827B2
公开(公告)日：2007-07-17
申请号：US10306631
申请日：2002-11-27
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
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公开(公告)号：US20070061901A9
公开(公告)日：2007-03-15
申请号：US10147368
申请日：2002-05-15
申请人： Aya Jakobovits , Mary Faris , Arthur Raitano , Robert Morrison , Douglas Saffran , Wangmao Ge , Pia Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Arthur Raitano , Robert Morrison , Douglas Saffran , Wangmao Ge , Pia Challita-Eid
CPC分类号： G01N33/68 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/47 , C07K14/705 , C07K16/28 , C07K2317/34 , G01N33/5017 , G01N33/57434
摘要： A novel gene (designated 101P3A11 or PHOR-1) and its encoded protein, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为101P3A11或PHOR-1）及其编码蛋白及其变体，其中101P3A11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，101P3A11提供 诊断，预后，预防和/或治疗靶标。 101P3A11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与101P3A11反应的抗体或T细胞可用于主动或被动免疫。
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46.发明申请Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer 失效核酸和相应的题为184P1E2的蛋白质可用于治疗和检测癌症公开(公告)号：US20070054284A1
公开(公告)日：2007-03-08
申请号：US11368284
申请日：2006-03-02
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为184P1E2）及其编码的蛋白及其变体，其中184P1E2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，184P1E2提供诊断，预后， 癌症的预防和/或治疗靶标。 184P1E2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与184P1E2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20070041968A1
公开(公告)日：2007-02-22
申请号：US11156231
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K48/00 , A61K39/395 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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48.发明授权Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer 有权称为251P5G2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US08604169B2
公开(公告)日：2013-12-10
申请号：US12651336
申请日：2009-12-31
IPC分类号： C07K16/00 , C12P21/08 , G01N33/53 , A61K39/395 , A61K39/21
CPC分类号： C12N5/0693 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K47/6851 , A61K2039/505 , C07K14/435 , C07K14/47 , C07K2319/00 , G01N33/57484 , Y02A50/466
摘要： A novel gene 251P5G2 and its encoded protein, and variants thereof, are described wherein 251P5G2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 251P5G2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 251P5G2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 251P5G2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因251P5G2及其编码的蛋白及其变体，其中251P5G2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，251P5G2提供诊断，预后，预防和/ 或癌症的治疗靶标。 251P5G2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与251P5G2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08298776B2
公开(公告)日：2012-10-30
申请号：US12829256
申请日：2010-07-01
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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50.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 193P1E1B USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和相关蛋白193P1E1B被用于治疗和检测癌症公开(公告)号：US20120202208A1
公开(公告)日：2012-08-09
申请号：US13450405
申请日：2012-04-18
申请人： Arthur B. RAITANO , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. RAITANO , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A50/466
摘要： A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因0193P1E1B（也称为193P1E1B）及其编码的蛋白质及其变体，其中193P1E1B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，193P1E1B提供诊断， 癌症的预后，预防和/或治疗靶标。 193P1E1B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与193P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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