摘要:
Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify the locations of intraluminal structures and medical devices during non-surgical medical techniques, by determining the conductance and/or cross-sectional area at a plurality of locations within the body lumen.
摘要:
Impedance devices for obtaining conductance measurements within luminal organs. In at least one embodiment of an impedance device of the present disclosure, the device, comprises an elongated body and an detector positioned upon the elongated body, the detector comprising at least five electrodes and configured to obtain one or more conductance measurements generated using a first arrangement of four of the at least five electrodes and further configured to obtain one or more fluid velocity measurements using a second arrangement of four of the at least five electrodes when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the first arrangement is different from the second arrangement.
摘要:
Devices, systems, and methods to measure parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determine plaque vulnerability using temperature. In at least one embodiment of a method to obtain parallel tissue conductance, the method comprises the steps of inserting at least part of a detection device into a luminal organ, applying current thereto, obtaining a native temperature measurement, injecting a solution of a known conductivity into the luminal organ, detecting a temperature change indicative of the fluid within the luminal organ, measuring an output conductance, and calculating a parallel tissue conductance based upon the output conductance and the conductivity of the injected solution.
摘要:
Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify the locations of intraluminal structures and medical devices during non-surgical medical techniques, such as cardiac ablation, by determining the intralumen conductance and/or cross-sectional area at a plurality of locations within the body lumen.
摘要:
Blood filter devices, systems, and methods of using the same to detect the presence of a thrombus within said filter devices. A device of the present disclosure for detecting a thrombus or other blood particulate matter of a threshold size within a vessel can comprise a filter having a head and a plurality of legs extending distally therefrom, configured to capture the thrombus or other blood particulate matter of at least a threshold size, and at least one impedance element positioned distal to the head and configured to detect a presence of the thrombus or other blood particulate matter of at least a threshold size within the filter by obtaining data within a bloodstream when the filter is positioned within the bloodstream.
摘要:
Methods and products for diagnosing, treating and/or delaying onset of chronic allograft rejection, including cardiac allograft vasculopathy. In an exemplary embodiment of a noninvasive method of screening a cardiac allograft recipient for being at-risk for developing cardiac allograft vasculopathy of the present disclosure, the method comprises the steps of withdrawing at least one biological sample from a cardiac allograft recipient; and analyzing the at least one biological sample for one or more biomarkers indicative of the presence of fibrin deposits within the cardiac allograft microvasculature; wherein detection of the one or more biomarkers indicates that the cardiac allograft recipient is at-risk for or developing cardiac allograft vasculopathy.
摘要:
Impedance devices and methods of using the same to obtain luminal organ measurements. In at least one embodiment of an impedance device of the present disclosure, the impedance device comprises an elongated body having a distal body end, and a first electrode located along the elongated body at or near the distal body end, the first electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, wherein a measured parameter of the mammalian luminal organ can be calculated based in part upon the one or more conductance values obtained by the first electrode.
摘要:
Luminal organ sizing devices and methods. In at least one embodiment of a method of the present disclosure, the method comprises the steps of introducing at least part of a first device into a luminal organ at an aperture or opening of the luminal organ, the first device having a balloon positioned thereon; inflating the balloon at the aperture or opening of the luminal organ until a point of apposition is achieved; and obtaining a first aperture or opening measurement based upon the point of apposition.
摘要:
The present application provides various devices, systems, and methods for removing stenotic lesions from vessels. In at least one embodiment of an exemplary device of the present disclosure, the device comprises at least one treatment portion operable to remove at least part of a stenotic lesion, and at least one sizing portion operable to measure a first luminal size parameter when positioned and operated at a first location and further operable to measure a second luminal size parameter when positioned and operated at a second location, wherein the device comprises an elongated body selected from the group consisting of a catheter and a wire.
摘要:
Methods to generate luminal organ profiles using impedance. One embodiment of such a method comprises the steps of introducing an impedance device having at least two detection electrodes positioned in between at least two excitation electrodes into a treatment site of a luminal organ at a first position, measuring a first treatment site conductance at the first position using the impedance device and at least two injections of solutions having different conductivities, moving the impedance device to a second position in the luminal organ, measuring a second treatment site conductance at the second position using the impedance device and the at least two injections of solutions having different conductivities, calculating a first position cross-sectional area using the first treatment site conductance and a second position cross-sectional area using the second treatment site conductance, and constructing a profile of the treatment site.