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41.发明授权Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders 有权用于检测微生物和细胞的方法和组合物以及疾病和病症的治疗公开(公告)号：US07820184B2
公开(公告)日：2010-10-26
申请号：US12008659
申请日：2008-01-11
IPC分类号： A61K39/108 , A61K49/00 , C12Q1/00
CPC分类号： G01N33/56916 , A61K33/24 , A61K33/26 , A61K35/74 , A61K45/06 , G01N33/57484 , G01N2333/245 , A61K2300/00
摘要： Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and methods that microorganisms or cells for treating a disease, disorder or condition are provided. Sites, diseases and disorders include sites of cell proliferation, proliferative conditions, neoplasms, tumors, neoplastic disease, wounds and inflammation. Also provided are microorganisms and cells for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a microorganism or cell.
摘要翻译： 用于检测受试者中的微生物或细胞的方法和使用微生物或细胞检测，成像或诊断受试者的部位，疾病，病症或病症的方法以及提供用于治疗疾病，病症或病症的微生物或细胞的方法。 部位，疾病和病症包括细胞增殖，增生病症，肿瘤，肿瘤，肿瘤疾病，伤口和炎症的部位。 还提供了用于包含微生物或细胞的方法和组合物，组合和试剂盒（包括诊断和药物组合物）中的微生物和细胞。
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42.发明申请Use of modified vaccinia virus strains in combination with a chemotherapeutic agent for use in therapeutic methods 审中-公开使用修饰的痘苗病毒株与化学治疗剂组合用于治疗方法公开(公告)号：US20100196325A1
公开(公告)日：2010-08-05
申请号：US12660513
申请日：2010-02-25
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu
IPC分类号： A61K35/76 , A61K31/675 , A61K31/522 , A61K31/506 , A61K31/52 , A61P35/00
CPC分类号： A61K31/70 , A61K31/7068 , A61K35/768 , C12N2710/24132 , C12N2710/24143 , A61K2300/00
摘要： Modified or attenuated therapeutic viruses in combination with a chemotherapeutic agent, and methods for administering therapeutic viruses in combination with a chemotherapeutic agent to a subject for controlling viral titer, are provided. The combination of a therapeutic virus and chemotherapeutic agent can be used in methods of treating diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The combination can also be used as a preventive measure or as a treatment to reduce or eliminate symptoms associated with oncolytic viral therapy.
摘要翻译： 提供了与化学治疗剂组合的改良或减毒治疗病毒，以及将治疗性病毒与化疗剂组合施用于受试者以控制病毒滴度的方法。 治疗性病毒和化学治疗剂的组合可用于治疗诸如增殖性和炎症性疾病（包括作为抗肿瘤剂）的疾病的方法。 该组合也可用作预防措施或作为治疗以减少或消除与溶瘤病毒治疗相关的症状。
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43.发明申请Methods for assessing effectiveness and monitoring oncolytic virus treatment 审中-公开评估有效性和监测溶瘤病毒治疗的方法公开(公告)号：US20140087362A1
公开(公告)日：2014-03-27
申请号：US13815727
申请日：2013-03-13
申请人： Aladar A. Szalay , Nanhai G. Chen , Huiqiang Wang , Melody Fells , Albert Roeder , Qian Zhang , Boris Minev
发明人： Aladar A. Szalay , Nanhai G. Chen , Huiqiang Wang , Melody Fells , Albert Roeder , Qian Zhang , Boris Minev
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , A61K38/00 , C07K14/00 , C07K16/28 , C07K2317/34 , C07K2319/00 , C12N2710/24132 , C12N2710/24162 , C12N2710/24171 , G01N33/57496 , G01N2800/52
摘要： Diagnostic methods for in vivo and ex vivo detection of circulating tumor cells (CTCs) for the diagnosis and treatment of cancer are provided. The diagnostic methods employ oncolytic viruses alone or in combination with one or more tumor cell enrichment and/or detection methods. Combinations and kits for use in the practicing the methods also are provided.
摘要翻译： 提供了用于诊断和治疗癌症的循环肿瘤细胞（CTC）的体内和体外检测的诊断方法。 诊断方法单独使用溶瘤病毒或与一种或多种肿瘤细胞富集和/或检测方法组合使用。 还提供了用于实施该方法的组合和试剂盒。
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44.发明申请Compositions containing protein polymers and vaccinia virus, and methods of use thereof 审中-公开含有蛋白质聚合物和痘苗病毒的组合物及其使用方法公开(公告)号：US20140086976A1
公开(公告)日：2014-03-27
申请号：US13987688
申请日：2013-08-20
CPC分类号： A61K47/42 , A61K35/76 , C12N7/00 , C12N2710/24132 , C12N2710/24171
摘要： Provided herein are compositions containing a vaccinia virus and a protein polymer, and articles of manufacture thereof. Also provided are diagnostic and therapeutic methods using the compositions or articles of manufacture.
摘要翻译： 本文提供含有痘苗病毒和蛋白质聚合物的组合物及其制品。 还提供了使用组合物或制品的诊断和治疗方法。
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45.发明授权公开(公告)号：US08357486B2
公开(公告)日：2013-01-22
申请号：US12319640
申请日：2009-01-09
IPC分类号： C12Q1/00 , C12Q1/66 , A61K39/108
CPC分类号： A61K51/0491 , A61K31/7088 , A61K35/74 , A61K51/04 , A61K2035/11 , A61K2300/00 , C12N1/20 , Y02A50/473
摘要： Described herein are methods for detecting a bacteria in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using bacteria. The methods can be used in conjunction with methods for treating a disease, disorder or condition. Such sites, diseases and disorders include sites of cellular proliferation, such as tumors, tumor tissues, metastases, areas of inflammation, immunoprivileged sites or tissues, wounds and infections. Further described are bacteria for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a bacterium. Bacteria described herein include those that bind, sequester or accumulate radiolabeled compounds by expression of an endogenous gene product that binds to the radiolabeled compound. Additional imaging and therapeutic agents and methods also are described.
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公开(公告)号：US06984374B2
公开(公告)日：2006-01-10
申请号：US10356245
申请日：2003-01-30
申请人： Aladar A. Szalay , Shahrokh Shabahang , Yong Yu
发明人： Aladar A. Szalay , Shahrokh Shabahang , Yong Yu
CPC分类号： C12Q1/025 , C12Q1/04 , C12Q1/18 , G01N33/5088
摘要： A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a first detectable signal, exposing the material being evaluated to the bacteria and determining whether the first signal is present determining whether the first signal is present on the material or within the material.
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公开(公告)号：US20140271549A1
公开(公告)日：2014-09-18
申请号：US13999616
申请日：2014-03-11
申请人： Aladar A. Szalay
发明人： Aladar A. Szalay
IPC分类号： A61K38/14 , A61K48/00 , A61K31/431 , A61K31/407 , A61K35/76 , A61K31/7036
CPC分类号： A61K38/14 , A61K31/403 , A61K31/4164 , A61K31/43 , A61K31/431 , A61K31/7036 , A61K31/7048 , A61K35/74 , A61K35/768 , A61K38/162 , A61K45/06 , C12N2710/24132 , C12N2710/24143 , Y02A50/465 , A61K2300/00
摘要： Provided are methods for increasing the therapeutic efficacy of viral therapy by administering an antibiotic effective against commensal bacteria with the viral therapy. Included are methods for treating cancers, tumors and metastases by administering the virus and the antibiotic.
摘要翻译： 提供了通过用病毒治疗施用对共生细菌有效的抗生素来增加病毒治疗的治疗功效的方法。 包括通过施用病毒和抗生素治疗癌症，肿瘤和转移瘤的方法。
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48.发明授权公开(公告)号：US08343509B2
公开(公告)日：2013-01-01
申请号：US13199567
申请日：2011-09-01
IPC分类号： A61K39/108 , A61K39/02 , C12Q1/00
CPC分类号： A61K51/0491 , A61K31/7088 , A61K35/74 , A61K51/04 , A61K2035/11 , A61K2300/00 , C12N1/20 , Y02A50/473
摘要： Described herein are methods for detecting a bacteria in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using bacteria. The methods can be used in conjunction with methods for treating a disease, disorder or condition. Such sites, diseases and disorders include sites of cellular proliferation, such as tumors, tumor tissues, metastases, areas of inflammation, immunoprivileged sites or tissues, wounds and infections. Further described are bacteria for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a bacterium. Bacteria described herein include those that bind, sequester or accumulate radiolabeled compounds by expression of an endogenous gene product that binds to the radiolabeled compound. Additional imaging and therapeutic agents and methods also are described.
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49.发明申请MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY 审中-公开用于预防和治疗细胞治疗的神经细胞的微生物公开(公告)号：US20110064650A1
公开(公告)日：2011-03-17
申请号：US12736826
申请日：2009-05-15
申请人： Aladar A. Szalay
发明人： Aladar A. Szalay
CPC分类号： A61K35/17 , A61K35/545 , A61K35/768 , A61K38/19 , A61K45/06 , A61K48/00 , C12N2710/24132 , A61K2300/00
摘要： Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by administration of cellular therapies, such as stem cell therapies. The methods also include contacting cellular compositions with oncolytic viruses for the removal of neoplastic cells prior to administration of the cellular composition for therapy. Diagnostic methods for monitoring treatment also are provided.
摘要翻译： 提供使用细胞组合物与溶瘤病毒组合的方法。 所述方法包括施用溶瘤病毒用于抑制和治疗由施用细胞疗法引起的肿瘤，例如干细胞疗法。 所述方法还包括将细胞组合物与溶瘤病毒接触以在施用用于治疗的细胞组合物之前去除肿瘤细胞。 还提供了用于监测治疗的诊断方法。
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50.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法
公开(公告)号：US6077697A
公开(公告)日：2000-06-20
申请号：US682080
申请日：1996-07-15
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , A61K38/00 , A61K48/00 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/62 , C12N15/82 , C12N15/85 , C07H21/04 , C12N15/10
CPC分类号： C12N15/85 , A01K67/0275 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2227/40 , A01K2267/01 , A01K2267/03 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
摘要翻译： 提供了包含人造染色体的细胞系的制备方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人造染色体的方法，以及将染色体递送至所选择的细胞和组织的方法。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 特别地，提供除了插入的异源DNA之外，基本上由异染色质组成的卫星人造染色体。 还提供了使用人造染色体的方法，包括用于基因治疗，生产基因产物和转基因植物和动物的生产。
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