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41.发明授权Polynucleotides encoding extra cellular/epidermal growth factor HCABA58X polypepides 失效编码细胞外表皮生长因子HCABA58X多肽的多核苷酸
公开(公告)号：US5916769A
公开(公告)日：1999-06-29
申请号：US833963
申请日：1997-04-11
申请人： Henrik S. Olsen , Steven M. Ruben
发明人： Henrik S. Olsen , Steven M. Ruben
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/22 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/485 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/53 , C12N5/00 , C12N15/63
CPC分类号： C07K14/485 , C12Q1/6883 , A61K38/00 , A61K48/00 , C12Q2600/156
摘要： The present invention discloses a novel cDNA isolated from human osteoclastoma tissue which encodes a novel polypeptide identified herein as Extracellular/Epidermal Growth Factor HCABA58X owing in part to the presence in its amino acid sequence of epidermal growth factor (EGF) domains characteristic of the EGF family of polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides. Also disclosed are antagonists against such polypeptides and their uses. Also disclosed are diagnostic assays for detecting altered levels of the polypeptides of the present invention and mutations in the nucleic acid sequences which encode such polypeptides.
摘要翻译： 本发明公开了一种从人类破骨细胞瘤组织中分离的新型cDNA，其编码本文鉴定为细胞外/表皮生长因子HCABA58X的新型多肽，部分原因在于其EGF家族特征性表皮生长因子（EGF）结构域的氨基酸序列的存在 的多肽。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法。 还公开了抗这些多肽及其用途的拮抗剂。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码这种多肽的核酸序列中的突变。
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公开(公告)号：US20090104622A1
公开(公告)日：2009-04-23
申请号：US12144864
申请日：2008-06-24
申请人： Henrik S. Olsen , Haodong Li
发明人： Henrik S. Olsen , Haodong Li
CPC分类号： C07K14/485 , A61K38/00 , A61K48/00 , C07K14/47 , C12N2799/026
摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.
摘要翻译： 本发明公开了细胞外/表皮生长因子多肽和编码这些多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括诱导DNA合成，刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病以及刺激胚胎发生和血管发生。 还公开了抗这种多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。
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公开(公告)号：US07326537B2
公开(公告)日：2008-02-05
申请号：US11076158
申请日：2005-03-10
申请人： Henrik S. Olsen , Mark D. Adams
发明人： Henrik S. Olsen , Mark D. Adams
CPC分类号： C07H21/04 , A61K38/00 , C07K14/575 , C07K16/26 , C07K2317/24 , C07K2317/55 , Y10S530/835
摘要： The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Human Corpuscles of Stannius protein inhibits calcium uptake and reduces renal excretion of phosphate. Also provided is a diagnostic assay to detect mutations in the nucleic acid sequence encoding the polypeptide and for altered concentrations of the polypeptide in a sample derived from a host.
摘要翻译： 本发明涉及人类Stannius多肽多糖和编码这种多肽的DNA（RNA）。 还提供了通过重组技术和针对这种多肽的拮抗剂生产此类多肽的方法。 人类斯坦尼斯蛋白质蛋白质抑制钙摄取并减少磷酸盐的肾排泄。 还提供了用于检测编码多肽的核酸序列中的突变和来自宿主的样品中多肽的变化浓度的诊断测定法。
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公开(公告)号：US5994103A
公开(公告)日：1999-11-30
申请号：US460529
申请日：1995-06-02
CPC分类号： C07H21/04 , C07K14/575
摘要： A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of electrolyte disorders which lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use therapeutically to treat hypocalcemia and osteoporosis are also disclosed. Use of the stanniocalcin-alpha sequence as a diagnostic to detect diseases or the susceptibility to diseases related to a mutated form of stanniocalcin-alpha seqeunces is also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类猕猴素α多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗导致肾，骨和心脏病以及骨质疏松症和佩吉特氏病的电解质紊乱的方法。 还公开了抗这些多肽的拮抗剂及其治疗性治疗低钙血症和骨质疏松症的用途。 还公开了将锡氨钙素-α序列用作诊断疾病或与突变形式的猕猴桃苷酸相关的疾病的易感性的用途。
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公开(公告)号：US06391589B1
公开(公告)日：2002-05-21
申请号：US09479729
申请日：2000-01-07
申请人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
发明人： Henrik S. Olsen , Haodong Li , Mark D. Adams , Solange H. L. Gentz , Ralph Alderson , Yuling Li , David Parmelee , John R. White , Edward R. Appelbaum
IPC分类号： C12N510
CPC分类号： C07K14/523 , A61K38/00 , C07K2319/00
摘要： Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
摘要翻译： 公开了人趋化因子β-10多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。
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公开(公告)号：US06974682B1
公开(公告)日：2005-12-13
申请号：US08917710
申请日：1997-08-26
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子IL-1R也提供了如用于制备它们的载体，宿主细胞和重组方法的AcM多肽。 还提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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公开(公告)号：US5994301A
公开(公告)日：1999-11-30
申请号：US431117
申请日：1995-04-28
申请人： Henrik S. Olsen , Mark D. Adams
发明人： Henrik S. Olsen , Mark D. Adams
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P3/00 , A61P3/02 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/56 , C07K14/575 , C07K16/18 , C07K16/26 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , A61K38/17 , A61K38/04 , C07K14/435
CPC分类号： C07H21/04 , C07K14/575 , C07K16/26 , A61K38/00 , C07K2317/24 , C07K2317/55 , Y10S530/835
摘要： The present invention relates to human Corpuscles of Stannius polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antagonists against such polypeptides. Also provided are methods of using the polypeptide therapeutically for treating renal, bone and heart diseases and for using the antagonists for treating hypocalcemia and osteoporosis. Also provided is a diagnostic assay to detect mutations in the nucleic acid sequence encoding the polypeptide and for altered concentrations of the polypeptide in a sample derived from a host.
摘要翻译： 本发明涉及人类Stannius多肽多糖和编码这种多肽的DNA（RNA）。 还提供了通过重组技术和针对这种多肽的拮抗剂生产此类多肽的方法。 还提供了使用该多肽治疗性治疗肾，骨和心脏病以及使用拮抗剂治疗低钙血症和骨质疏松症的方法。 还提供了用于检测编码多肽的核酸序列中的突变和来自宿主的样品中多肽的变化浓度的诊断测定法。
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公开(公告)号：US5945273A
公开(公告)日：1999-08-31
申请号：US867970
申请日：1997-06-03
CPC分类号： C12Q1/6883 , C12N9/88 , A61K38/00
摘要： A human oxalyl-CoA decarboxylase polypeptide and DNA(RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques and for producing an antibody against such polypeptide are disclosed. Also disclosed is a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptide for the treatment of urolithiasis and hyperoxaluria. Also disclosed are assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention.
摘要翻译： 公开了人草酰-CoA脱羧酶多肽和编码这种多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法和用于产生抗这种多肽的抗体。 还公开了本发明的多肽与合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗尿石症和高硫尿症。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并检测本发明多肽的改变水平的测定。
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公开(公告)号：US07482326B2
公开(公告)日：2009-01-27
申请号：US11272757
申请日：2005-11-15
IPC分类号： C07K14/435 , C07K14/475 , C07K14/52 , C07K14/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19
CPC分类号： C07K14/52
摘要： A human EMAP III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating neoplasia. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
摘要翻译： 公开了编码这种多肽的人类EMAP III多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽预防和/或治疗瘤形成的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。
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公开(公告)号：US07390880B2
公开(公告)日：2008-06-24
申请号：US11066006
申请日：2005-02-25
CPC分类号： C07H21/04 , C07K14/7155
摘要： The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are futher provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
摘要翻译： 本发明涉及作为Ig超家族成员的新型可溶性IL-1受体辅助分子（IL-1RACM）蛋白质。 特别地，提供编码人IL-1R AcM蛋白的分离的核酸分子。 还提供IL-1R AcM多肽，载体，宿主细胞和用于制备它们的重组方法。 提供筛选方法用于鉴定IL-1信号转导的激动剂和拮抗剂。 本发明还涉及用IL-1R AcM拮抗剂治疗生理和病理疾病状况的方法。
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