公开(公告)号：US20230069843A1

公开(公告)日：2023-03-09

申请号：US16492588

申请日：2018-03-08

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： James R. Heath ,  Songming Peng ,  Alphonsus Hon-Chung Ng

IPC: C12N15/10 ,  B01L3/00

Abstract: Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described. Microfluidic devices useful for identifying antigen-specific T cells, and methods of using the same, are also described.

公开(公告)号：US20230019342A1

公开(公告)日：2023-01-19

申请号：US17850743

申请日：2022-06-27

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Arundhati Nag ,  Samir Das ,  Joseph O. Varghese ,  Ryan K. Henning

IPC: G01N33/574 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/48 ,  G01N33/58

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20210025901A1

公开(公告)日：2021-01-28

申请号：US16827001

申请日：2020-03-23

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： James R. Heath ,  Heather Agnew ,  Blake Farrow ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das ,  Bert Tsunyin Lai ,  Suresh Mark Pitram

IPC: G01N33/68 ,  C07K14/54 ,  C07K7/06 ,  C07K7/64

Abstract: The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US20190195869A1

公开(公告)日：2019-06-27

申请号：US16191207

申请日：2018-11-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rong Fan ,  Habib Ahmad ,  James R. Heath

IPC: G01N33/543 ,  B01L3/00 ,  B01J19/00 ,  G01N33/58

CPC classification number: G01N33/54393 ,  B01J19/0046 ,  B01J2219/00547 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0636 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N33/54366 ,  G01N33/582 ,  G01N2458/10

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

公开(公告)号：US10305014B2

公开(公告)日：2019-05-28

申请号：US14924596

申请日：2015-10-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Akram Boukai ,  Yuri Bunimovich ,  William A. Goddard ,  James R. Heath ,  Jamil Tahir-Kheli

IPC: H01L35/26 ,  H01L35/32 ,  H01L35/34

Abstract: Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled substantially independently of the electrical conductivity of the nanowires by controlling dimensions and doping, respectively, of the nanowires. A thermoelectric device comprising p-doped and n-doped semiconductor nanowire thermocouples is also shown, together with a method to fabricate alternately p-doped and n-doped arrays of silicon nanowires.

公开(公告)号：US20180364253A1

公开(公告)日：2018-12-20

申请号：US16010347

申请日：2018-06-15

Applicant: Indi Molecular, Inc. ,  California Institute of Technology

Inventor： Heather Agnew ,  Bert Tsunyin Lai ,  Suresh Mark Pitram ,  Blake Farrow ,  James R. Heath ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das

IPC: G01N33/68 ,  C07K7/06

Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US20180284123A1

公开(公告)日：2018-10-04

申请号：US15942351

申请日：2018-03-30

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Amy M. McCarthy ,  Jungwoo Kim

IPC: G01N33/58 ,  G01N33/50 ,  G01N33/68 ,  G01N33/552 ,  G01N33/483

Abstract: Disclosed are devices, compositions, and methods useful for assessing properties of compounds and molecules, such a binding, kinetic, and enzymatic properties, simultaneously for multiple compounds or molecules and/or under multiple conditions, efficiently, rapidly, and combinations of these. By using certain features alone or together in the save device or assay, the disclosed devices, compositions, and methods provide improvements over, and solve problems present in, prior assay devices and methods.

公开(公告)号：US20170138942A1

公开(公告)日：2017-05-18

申请号：US15359464

申请日：2016-11-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rong Fan ,  Habib Ahmad ,  James R. Heath

IPC: G01N33/543 ,  G01N33/58

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.