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公开(公告)号：US09649496B2
公开(公告)日：2017-05-16
申请号：US14494099
申请日：2014-09-23
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Ramesh Wariar , Qi An
IPC: A61N1/36 , A61N1/365 , A61B7/00 , A61B5/02 , A61B5/0468 , A61B5/00 , A61B5/0456
CPC classification number: A61N1/36585 , A61B5/02028 , A61B5/0456 , A61B5/0468 , A61B5/4836 , A61B7/00 , A61N1/36521 , G06F19/00
Abstract: A system includes a therapy control circuit, a therapy output circuit; and a physiologic interval sensing circuit configured to receive information about subject physiologic intervals. The therapy circuit is configured to determine a change in therapy that is provided by the therapy output circuit, determine that the change in therapy includes a change to a maximum interval of cardiac electrostimulation provided according to the therapy, detecting a change in a ventricular filling characteristic of the subject in response to the change in maximum interval of cardiac electrostimulation, determine an indication of a physiologic response of the subject to the therapy change using information about the change in the ventricular filling characteristic, and update the subject therapy provided by the therapy output circuit when the determined indication of the physiologic response to the therapy change indicates an increased likelihood of worsening health status of the subject.
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公开(公告)号：US20170119317A1
公开(公告)日：2017-05-04
申请号：US15335754
申请日：2016-10-27
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Qi An , Viktoria A. Averina , John D. Hatlestad , Yi Zhang
CPC classification number: A61B5/7275 , A61B5/02 , A61B5/02028 , A61B5/04004 , A61B5/053 , A61B5/0535 , A61B5/1102 , A61B5/4836 , A61B5/4842 , A61B5/686 , A61B5/7225 , A61B5/7282 , A61B7/00 , A61B7/023 , A61B7/04 , A61B8/0883 , A61B2505/07 , G16H40/63 , G16H50/20 , G16H50/30
Abstract: Systems and methods for detecting cardiac conditions such as events indicative of worsening of heart failure (HF) are described. A system can receive a physiological signal from a patient, transform one or more first portions of the physiological signal into respective one or more baseline statistical values, transform one or more second portions of the physiological signal into one or more historical extreme values, and generate one or more reference values of a physiologic parameter using the baseline statistical values and the historical extreme values. The system can transform one or more third signal portions of the physiological signal into respective one or more short-term values, and produce a cardiac condition indicator using a combination of relative differences between the short-term values and the corresponding reference values. The system can output the cardiac condition indicator, or deliver therapy according to the cardiac condition indicator.
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公开(公告)号：US20170027527A1
公开(公告)日：2017-02-02
申请号：US15190511
申请日：2016-06-23
Applicant: Cardiac Pacemakers, Inc.
CPC classification number: A61B5/742 , A61B5/02028 , A61B5/042 , A61B5/1107 , A61B5/4842 , A61B5/6801 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/743 , A61B5/7445 , A61B5/746 , A61B7/04 , A61N1/36585 , A61N1/3987 , G16H50/20 , G16H50/30
Abstract: Devices and methods for detecting an event using a variable threshold. A patient monitoring system can receive physiologic information and compare the information to an onset threshold. When the onset threshold is exceeded, the system shifts to a reset threshold that is different than the onset threshold. When the reset threshold is crossed, the system shifts back to the onset threshold.
Abstract translation: 使用变量阈值检测事件的设备和方法。 患者监测系统可以接收生理信息并将信息与起始阈值进行比较。 当超过起始阈值时，系统转移到与起始阈值不同的复位阈值。 当复位阈值越过时，系统转回到起始阈值。
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公开(公告)号：US20170001005A1
公开(公告)日：2017-01-05
申请号：US15176915
申请日：2016-06-08
Applicant: Cardiac Pacemakers, Inc.
Inventor： Yi Zhang , Viktoria A. Averina , Pramodsingh Hirasingh Thakur
CPC classification number: A61N1/3627 , A61B5/02438 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61N1/36535 , A61N1/36542 , A61N1/36585 , A61N1/3702 , G06F19/00
Abstract: Systems, devices, or methods can be used to detect an event, or series of events, that can indicate worsening of congestive heart failure (CHF), or can be used to identify a subject at an elevated risk for developing CHF. A CHF event predictor can be provided using a characteristic minimum of subject cardiac intervals. In an example, the subject cardiac intervals can be obtained during a night-time period or during periods of reduced subject physical activity. A CHF event predictor can be determined using information about physiologic signals received from a subject, such as from a physiologic sensor associated with an ambulatory or implantable medical device.
Abstract translation: 可以使用系统，装置或方法来检测可以指示充血性心力衰竭（CHF）恶化的事件或一系列事件，或者可用于识别发生CHF风险升高的受试者。 可以使用主题心脏间隔的特征最小值来提供CHF事件预测器。 在一个示例中，可以在夜间期间或在减少的对象身体活动期间获得受试者的心脏间隔。 可以使用关于从受试者接收的生理信号的信息来确定CHF事件预测器，例如来自与流动或可植入医疗装置相关联的生理传感器。
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公开(公告)号：US20160324467A1
公开(公告)日：2016-11-10
申请号：US15213120
申请日：2016-07-18
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , David L. Ternes , Stephen B. Ruble
CPC classification number: A61B5/4818 , A61B5/02405 , A61B5/053 , A61B5/0809 , A61B5/0826 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B7/02 , A61B7/04 , A61B2560/0475
Abstract: Disclosed herein, among other things, are methods and apparatus related to identification of apnea type. One aspect of the present subject matter provides a method for real-time apnea discrimination. The method includes sensing an impedance-based tidal volume signal to monitor a respiratory cycle of a patient, and detecting a reduction in tidal swing using the sensed impendence to detect an apnea event. When the apnea event is detected, a shape of the sensed signal is compared to a stored signal shape to determine whether the apnea event is primarily an obstructive sleep apnea (OSA) event or primarily a central sleep apnea (CSA) event, in various embodiments.
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Patent Agency Ranking
公开(公告)号：US20160228012A1
公开(公告)日：2016-08-11
申请号：US15132705
申请日：2016-04-19
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , Qi An , Barun Maskara
Abstract: An apparatus, such as a cardiac function management system can detect heart sounds following a sensed transition in physical activity level, such as from an elevated physical activity level to rest. A technique can include systems, methods, machine-readable media, or other techniques that can include identifying a physical activity level transition, receiving a heart sound signal, determining characteristics of the heart sound and subject physiologic activity to provide an indication, such as a heart failure status indication.
Abstract translation: 诸如心脏功能管理系统的装置可以在物理活动水平感知到的转变之后检测心音，例如从升高的身体活动水平到休息。 一种技术可以包括系统，方法，机器可读介质或其他技术，其可以包括识别身体活动水平转换，接收心脏声音信号，确定心脏声音的特征和受试者生理活动以提供指示，例如 心力衰竭状态指示。
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公开(公告)号：US09402563B2
公开(公告)日：2016-08-02
申请号：US14638142
申请日：2015-03-04
Applicant: Cardiac Pacemakers, Inc.
Inventor： Pramodsingh Hirasingh Thakur , David J. Ternes , Stephen B. Ruble
CPC classification number: A61B5/4818 , A61B5/02405 , A61B5/053 , A61B5/0809 , A61B5/0826 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B5/742 , A61B7/02 , A61B7/04 , A61B2560/0475
Abstract: Disclosed herein, among other things, are methods and apparatus related to identification of apnea type. One aspect of the present subject matter provides a method for real-time apnea discrimination. The method includes sensing an impedance-based tidal volume signal to monitor a respiratory cycle of a patient, and detecting a reduction in tidal swing using the sensed impendence to detect an apnea event. When the apnea event is detected, a shape of the sensed signal is compared to a stored signal shape to determine whether the apnea event is primarily an obstructive sleep apnea (OSA) event or primarily a central sleep apnea (CSA) event, in various embodiments.
Abstract translation: 本文公开了与呼吸暂停类型的鉴定相关的方法和装置。 本主题的一个方面提供了一种用于实时呼吸暂停辨别的方法。 该方法包括感测基于阻抗的潮气量信号以监测患者的呼吸周期，并且使用感测到的阻抗来检测潮汐摆动的减少以检测呼吸暂停事件。 当检测到呼吸暂停事件时，将感测信号的形状与存储的信号形状进行比较，以确定呼吸暂停事件是否主要是阻塞性睡眠呼吸暂停（OSA）事件或主要是中枢性睡眠呼吸暂停（CSA）事件，在各种实施例中 。
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48.发明授权Heart sound detection systems and methods using updated heart sound expectation window functions 有权心脏声音检测系统和方法使用更新的心音期望窗函数公开(公告)号：US09375152B2
公开(公告)日：2016-06-28
申请号：US13767362
申请日：2013-02-14
Applicant: CARDIAC PACEMAKERS, INC.
Inventor： Qi An , Pramodsingh Hirasingh Thakur
CPC classification number: A61B5/0205 , A61B5/024 , A61B5/0816 , A61B5/1102 , A61B5/1116 , A61B5/7264 , A61B5/7289 , A61B7/00 , A61B7/04 , G06F19/00
Abstract: Heart sound detection systems and methods can use updated heart sound expectation window functions to detect heart sounds. In an example, an initial heart sound expectation window function that describes a heart sound timing can be a function of a physiologic variable such as heart rate, intrinsic vs. non-intrinsic beat, respiration rate, index of circadian timing, or posture. The function can include at least one characteristic parameter that describes a value of the heart sound timing at a specified value of the physiologic variable. In an example, information about a patient heart sound can be detected and used to update a characteristic parameter of an initial heart sound expectation window function, and an updated heart sound expectation window function can be provided using the updated characteristic parameter.
Abstract translation: 心音检测系统和方法可以使用更新的心音期望窗函数来检测心音。 在一个示例中，描述心音定时的初始心音期望窗函数可以是诸如心率，内在与非内在搏动，呼吸率，昼夜节律指标或姿势之类的生理变量的函数。 该功能可以包括描述在生理变量的指定值处的心音定时的值的至少一个特征参数。 在一个示例中，可以检测关于患者心音的信息并用于更新初始心音期望窗函数的特征参数，并且可以使用更新的特征参数提供更新的心音期望窗函数。
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公开(公告)号：US09320906B2
公开(公告)日：2016-04-26
申请号：US14187954
申请日：2014-02-24
Applicant: Cardiac Pacemakers, Inc.
Inventor： Barun Maskara , Qi An , Pramodsingh Hirasingh Thakur , Julie A. Thompson
CPC classification number: A61N1/371 , A61N1/3627 , A61N1/36578 , A61N1/3684
Abstract: An apparatus may include an implantable therapy circuit that provides bi-ventricular pacing to a subject, a heart sound signal sensing circuit that produces a sensed heart sound signal that is representative of at least one heart sound associated with mechanical cardiac activity, a memory circuit to store one or more heart sound templates of cardiac capture, and a comparison circuit that compares a segment of the sensed heart sound signal to the one or more heart sound templates of cardiac capture to identify ventricles in which cardiac capture was induced by the bi-ventricular pacing. In some situations, an indication of the ventricles in which cardiac capture was induced may be generated according to the comparison.
Abstract translation: 一种装置可以包括向对象提供双心室起搏的可植入治疗电路，产生感测的心音信号的心音信号感测电路，所述心音信号代表与机械心脏活动相关联的至少一个心音，存储电路 存储心脏捕获的一个或多个心脏声音模板，以及比较电路，其将感测到的心音信号的一段与心脏采集的一个或多个心音模板进行比较，以识别其中双心室诱发心脏捕获的心室 起搏 在某些情况下，可以根据比较产生诱发心脏捕获的心室的指示。
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50.发明申请公开(公告)号：US20160106986A1
公开(公告)日：2016-04-21
申请号：US14882849
申请日：2015-10-14
Applicant: Cardiac Pacemakers, Inc.
Inventor： Qi An , Pramodsingh Hirasingh Thakur , Yinghong Yu
CPC classification number: A61N1/36585 , A61N1/056 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N1/3686
Abstract: An example of a system for pacing through multiple electrodes in a ventricle includes a sensing circuit to sense cardiac signal(s), a pacing output circuit to deliver pacing pulses, a heart sound sensor to sense a heart sound signal, and a control circuit to control the delivery of the pacing pulses. The control circuit includes a heart sound detector to detect heart sounds using the heart sound signal, an electrical event detector to detect cardiac electrical events using the cardiac signal(s), a measurement module to measure an optimization parameter using the detected heart sounds, and an optimization module to approximately optimize one or more pacing parameters using the measured optimization parameter. The one or more pacing parameters include an electrode configuration parameter specifying one or more electrodes selected from the multiple electrodes in the ventricle for delivering ventricular pacing pulses to that ventricle.
Abstract translation: 用于起搏通过心室中的多个电极的系统的示例包括用于感测心脏信号的感测电路，用于输送起搏脉冲的起搏输出电路，用于感测心脏声音信号的心脏声音传感器，以及控制电路 控制起搏脉冲的输送。 控制电路包括使用心音信号检测心音的心脏声音检测器，使用心脏信号检测心脏电气事件的电子事件检测器，使用检测到的心脏声音来测量优化参数的测量模块，以及 优化模块，以使用所测量的优化参数近似优化一个或多个起搏参数。 一个或多个起搏参数包括指定从心室中的多个电极中选择的一个或多个电极的电极配置参数，用于将心室起搏脉冲输送到心室。
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