公开(公告)号：US08109984B2

公开(公告)日：2012-02-07

申请号：US11326546

申请日：2006-01-04

申请人： Jan Otto Solem ,  Per-Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

发明人： Jan Otto Solem ,  Per-Ola Kimblad ,  Randolf von Oepen ,  Bodo Quint ,  Gerd Seibold ,  Kenneth J. Michlitsch ,  Suk-Woo Ha ,  Karl-Ludwig Eckert ,  Ib Joergensen ,  Stevan Nielsen

IPC分类号： A61F2/06

CPC分类号： A61F2/2451 ,  A61F2/07 ,  A61F2/88 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/8483 ,  A61F2210/0004

摘要： A device for treatment of mitral annulus dilation is disclosed, wherein the device comprises two states. In a first of these states the device is insertable into the coronary sinus and has a shape of the coronary sinus. When positioned in the coronary sinus, the device is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.

摘要翻译： 公开了一种用于治疗二尖瓣环扩张的装置，其中该装置包括两种状态。 在这些状态中的第一个状态下，该装置可插入冠状窦并具有冠状窦的形状。 当定位在冠状窦中时，假设曲率半径减小，装置可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。

公开(公告)号：US07972358B2

公开(公告)日：2011-07-05

申请号：US10523218

申请日：2003-07-25

申请人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

发明人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

IPC分类号： A61B17/08 ,  A61B17/34

CPC分类号： A61B17/00491 ,  A61B17/0057 ,  A61B2017/00654 ,  A61B2017/0472

摘要： Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

摘要翻译： 提供了用于通过将封闭剂递送到穿刺道周围的组织中引起穿刺道周围的减少来密封血管穿刺的装置。 产生的炎症反应和体积增加导致组织溶胀到穿刺道中，从而将其密封。

公开(公告)号：US07780725B2

公开(公告)日：2010-08-24

申请号：US10870340

申请日：2004-06-16

申请人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

公开(公告)号：US20090076598A1

公开(公告)日：2009-03-19

申请号：US12269213

申请日：2008-11-12

申请人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

公开(公告)号：US07316702B2

公开(公告)日：2008-01-08

申请号：US10622918

申请日：2003-07-18

申请人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Bremser ,  Randolf Von Oepen

发明人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Bremser ,  Randolf Von Oepen

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069

摘要： Apparatus and methods for providing distal protection during a medical procedure comprising a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

摘要翻译： 一种用于在医疗过程中提供远端保护的装置和方法，包括具有自膨胀多孔泡沫体的血管过滤器，所述自膨胀多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。 过滤器联接到诸如导丝的细长构件的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。

公开(公告)号：US06616682B2

公开(公告)日：2003-09-09

申请号：US09957482

申请日：2001-09-19

申请人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Bremser ,  Randolf von Oepen

发明人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Bremser ,  Randolf von Oepen

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069

摘要： Apparatus and methods for providing distal protection during a medical procedure comprising a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

摘要翻译： 一种用于在医疗过程中提供远端保护的装置和方法，包括具有自膨胀多孔泡沫体的血管过滤器，所述自膨胀多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。 过滤器联接到诸如导丝的细长构件的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。

公开(公告)号：US06416309B1

公开(公告)日：2002-07-09

申请号：US09505444

申请日：2000-02-16

申请人： Kenneth J. Michlitsch ,  Shaun Meredith ,  Daniel J. Keating ,  Yaakov Weinstein ,  Eugene Lee ,  Michael D. Rees ,  Darren Soetantyo ,  Sean Padgett ,  Steven D. Eppinger

发明人： Kenneth J. Michlitsch ,  Shaun Meredith ,  Daniel J. Keating ,  Yaakov Weinstein ,  Eugene Lee ,  Michael D. Rees ,  Darren Soetantyo ,  Sean Padgett ,  Steven D. Eppinger

IPC分类号： A23G0928

CPC分类号： A47J43/282

摘要： Methods and apparatus are provided for serving ice cream with a chemically-heated ice cream scoop. The scoop comprises a bowl and a handle with an interior cavity filled with a nontoxic, supercoolable salt solution. The salt solution may be selectively crystallized by triggering an activator in fluid communication with the solution. Crystallization evolves a significant amount of heat that is used to elevate the temperature of the scoop bowl, thereby decreasing the cutting force required to separate a serving of ice cream from a storage container and reducing adherence of the ice cream within the scoop bowl. After use, the scoop may be recharged by elevating the temperature of the crystallized solution above its crystallization temperature. The process of crystallization, melting, and supercooling may be repeated indefinitely.

摘要翻译： 提供了用化学加热的冰淇淋勺提供冰淇淋的方法和装置。 勺子包括碗和具有填充有无毒的过冷却盐溶液的内部空腔的手柄。 可以通过触发与溶液流体连通的活化剂来选择性地结晶盐溶液。 结晶产生大量的热量，用于提高勺子的温度，从而降低将冰淇淋从储存容器分离出来并减少勺子中冰淇淋粘附所需的切割力。 使用后，可以通过将结晶溶液的温度升高到其结晶温度以上来对勺子进行再充电。 结晶，熔化和过冷却的过程可以无限期地重复。

公开(公告)号：US09510817B2

公开(公告)日：2016-12-06

申请号：US13491273

申请日：2012-06-07

申请人： Vahid Saadat ,  Richard C. Ewers ,  Cang C. Laduca ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

发明人： Vahid Saadat ,  Richard C. Ewers ,  Cang C. Laduca ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

IPC分类号： A61B17/04 ,  A61B17/08 ,  A61B17/10 ,  A61B17/06 ,  A61B17/064 ,  A61B17/29 ,  A61B17/00 ,  A61B17/34

CPC分类号： A61F5/0086 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/06 ,  A61B17/06066 ,  A61B17/064 ,  A61B17/08 ,  A61B17/10 ,  A61B17/12013 ,  A61B17/1285 ,  A61B17/29 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0445 ,  A61B2017/0446 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0458 ,  A61B2017/0459 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/081 ,  A61B2017/3488

摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably dispose through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

摘要翻译： 本文描述了用于操纵和固定组织的装置。 在组织折叠在患者身体内部时，组织操作组件通常可以具有细长的管状构件，可滑动地配置穿过管状构件的接合构件和适于经由螺旋构件接合组织的远端，组织稳定构件 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US09017376B2

公开(公告)日：2015-04-28

申请号：US13174049

申请日：2011-06-30

申请人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

发明人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

IPC分类号： A61B17/08 ,  A61B17/00 ,  A61B17/04

CPC分类号： A61B17/00491 ,  A61B17/0057 ,  A61B2017/00654 ,  A61B2017/0472

摘要： Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

摘要翻译： 提供了用于通过将封闭剂递送到穿刺道周围的组织中引起穿刺道周围的减少来密封血管穿刺的装置。 产生的炎症反应和体积增加导致组织溶胀到穿刺道中，从而将其密封。

公开(公告)号：US08992608B2

公开(公告)日：2015-03-31

申请号：US12492512

申请日：2009-06-26

申请人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。