公开(公告)号：US20120014405A1

公开(公告)日：2012-01-19

申请号：US12850468

申请日：2010-08-04

申请人： David G. Anderson ,  Larry M. Youngblood ,  Guoxing Yang ,  Larry A. Spino ,  Scott K. Berkhous ,  Fang Fang

发明人： David G. Anderson ,  Larry M. Youngblood ,  Guoxing Yang ,  Larry A. Spino ,  Scott K. Berkhous ,  Fang Fang

IPC分类号： G01N33/22 ,  G01N25/00

CPC分类号： G01N33/2805

摘要： A thermal oxidation tester is shown for determining thermal stability of a fluid, particularly hydrocarbons when subjected to elevated temperatures. The tendency of the heated fluid to oxidize and (1) form deposits on a surface of a heater tube and (2) form solids therein, are both measured at a given flow rate, temperature and time. The measured results are used to determine whether a fluid sample passes or fails the test. Sample flow rate is important in the jet fuel thermal oxidation test. Current practice requires manual drop counting or flow confirmation with the use of volumetric glassware. An apparatus is described to precisely measure the flow rate and automatically perform flow rate check using a drip rate method and/or volumetric method.

摘要翻译： 示出了热氧化测试仪，用于确定流体，特别是当受到升高的温度时的烃的热稳定性。 加热的流体氧化的趋势和（1）在加热器管的表面上形成沉积物，和（2）在其中形成固体，都是在给定的流速，温度和时间下测量的。 测量结果用于确定流体样品是否通过或未通过测试。 样品流速在喷气燃料热氧化试验中很重要。 目前的做法是使用容积式玻璃器皿进行手动滴定计数或流量确认。 描述了一种设备来精确地测量流量并且使用滴流法和/或体积法自动执行流量检查。

公开(公告)号：US20100217040A1

公开(公告)日：2010-08-26

申请号：US12377000

申请日：2007-08-10

申请人： Wanbin Zhang ,  Fang Xie ,  Fang Fang

发明人： Wanbin Zhang ,  Fang Xie ,  Fang Fang

IPC分类号： C07F9/50

CPC分类号： C07F9/46

摘要： The present invention relates to a 2,2′,6,6′-tetrasubstituted aminophosphine ligand and its synthesis method. The structure of the ligand is shown as below. Its synthesis method comprises: Step (1) coupling 2,6-dinitrochlorobenzene as the starting material to obtain 2,2′,6,6′-tetranitrobiphenyl; Step (2): hydrogenating the 2,2′,6,6′-tetranitrobiphenyl with Pd/C to obtain 2,2′,6,6′-tetraminobiphenyl; Step (3): reacting the 2,2′,6,6′-tetraminobiphenyl with a phosphine halide to obtain the 2,2′,6,6′-tetrasubstituted aminophosphine ligand. The ligand of the present invention is an achiral compound, and its preparation method is simple. The ligand can be converted to a chiral bimetallic catalyst with single configuration eventually through introduction of external chirality. Moreover, the ligand can be used in various asymmetric reaction catalyzed by metals with high reactivity and stereoselectivity.

摘要翻译： 本发明涉及2,2'，6,6'-四取代氨基膦配体及其合成方法。 配体的结构如下所示。 其合成方法包括：步骤（1）以2,6-二硝基氯苯为原料，得到2,2'，6,6'-四硝基联苯; 步骤（2）：用Pd / C氢化2,2'，6,6'-四硝基二苯并得到2,2'，6,6'-四氨基联苯; 步骤（3）：使2,2'，6,6'-四磺酰联苯与卤化膦反应，得到2,2'，6,6'-四取代氨基膦配体。 本发明的配体是非手性化合物，其制备方法简单。 最终可以通过引入外部手性将配体转化为具有单一配置的手性双金属催化剂。 此外，配体可用于由具有高反应性和立体选择性的金属催化的各种不对称反应中。

公开(公告)号：US20070071742A1

公开(公告)日：2007-03-29

申请号：US11519322

申请日：2006-09-11

申请人： Fang Fang ,  Lori Kohlstaedt ,  John Reno

发明人： Fang Fang ,  Lori Kohlstaedt ,  John Reno

IPC分类号： A61K39/395 ,  C12N5/06 ,  C12N5/16

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/2821 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/412

摘要： Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e.g., HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.

摘要翻译： 提供了结合ICAM-1的人源化抗体。 抗体包括选自：SEQ ID NO：1和3（HumA）的那些; SEQ ID NO：5和7（HumB）; SEQ ID NO：9和11（HumC）; SEQ ID NO：13和15（HumD）; SEQ ID NO：17和19（HumE）; SEQ ID NO：21和23（HumF）; SEQ ID NO：25和27（HumG）; SEQ ID NO：29和31（HumH）; 和SEQ ID NO：33和35（HumI）。 还提供了能够结合ICAM-1表位的人源化抗体的子序列。 还提供了使用能够结合ICAM-1表位的人源化抗体抑制细胞病原体感染（例如HRV）的方法。

公开(公告)号：US10724605B2

公开(公告)日：2020-07-28

申请号：US16100998

申请日：2018-08-10

申请人： Zupeng Fang ,  Dan Fang ,  Lei Wang ,  Fang Fang ,  Yafeng Zhao

发明人： Zupeng Fang ,  Dan Fang ,  Lei Wang ,  Fang Fang ,  Yafeng Zhao

IPC分类号： F16H1/32 ,  H02K7/00 ,  H02K7/18 ,  B60K17/04 ,  B64D35/02 ,  H02K7/116 ,  F03D15/00 ,  B61C9/38 ,  B63H23/02

摘要： A main drive device of a planocentric set for three armed forces, including inner ring, outer ring, rolling column between the inner and outer rings at a side closer to the inner ring, and rolling pin shaft pairs installed between the inner and outer rings at a side closer to the outer ring; the inner ring is installed on an eccentric shaft and rotates driven by the eccentric shaft; the eccentric shaft is driven by a prime mover; when the rolling column is in contact with the inner ring, it contacts one of the two neighboring rolling pin shaft pairs to transmit power to the rolling pin shaft pairs in clockwise and counter-clockwise rotation; the rolling pin shaft pair drives the outer ring to rotate; the outer ring drives a planet wheel spoke to rotate, to drive a planocentric set planet wheel, and implement drive of a planocentric set.

公开(公告)号：US09022896B2

公开(公告)日：2015-05-05

申请号：US13603449

申请日：2012-09-05

申请人： Zupeng Fang ,  Dan Fang ,  Fang Fang ,  Yafeng Zhao

发明人： Zupeng Fang ,  Dan Fang ,  Fang Fang ,  Yafeng Zhao

IPC分类号： F16H57/08 ,  F16H1/32

CPC分类号： F16H1/32

摘要： A plane centric gear unit has a circumferentially floating ring gear 1. Both ends of the ring gear 1 are respectively fixed with cloth boards 3 equipped with hollow shaft sleeves 4; the reaction forces of the ring gear 1 and external gear 2 are equal and in opposite directions, and act on inner ring bearings 7 of the hollow shaft sleeves 4 on the same straight line; the outer ring bearings 8 of the hollow shaft sleeves 4 are unloaded, therefore the sum of the bearing reaction forces is reduced, the total transmission efficiency and power reaches above 97% and tens of thousands KW grade, the noises are lower, the gear surface contact pressure is about 1/10 of the external mesh pair, the gear surface contact life is increased by 1000 times than the external mesh pair, and the total weight is reduced by 2˜3 times.

摘要翻译： 平面中心减速器具有周向浮动的环形齿轮1.齿圈1的两端分别固定有装有中空轴套4的布板3; 环形齿轮1和外齿轮2的反作用力相等且相反方向，并且作用在同一直线上的中空轴套4的内圈轴承7上; 空心轴套4的外圈​​轴承8被卸载，因此轴承反作用力的总和减小，总传动效率和功率达到97％以上，几万KW级，噪声较低，齿轮面 接触压力约为外啮合对的1/10，齿轮表面接触寿命比外啮合对增加1000倍，总重量减少2〜3倍。

公开(公告)号：US20140113286A1

公开(公告)日：2014-04-24

申请号：US13997100

申请日：2011-12-21

申请人： Timothy Chan ,  Fang Fang ,  Sevin Turcan

发明人： Timothy Chan ,  Fang Fang ,  Sevin Turcan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154

摘要： Methods and kits for assessing risk of metastasis in a cancer patient identified as having breast cancer, colon cancer or glioma use analysis of a classifier for CpG island methylator phenotype.

摘要翻译： 鉴定为具有乳腺癌，结肠癌或神经胶质瘤的癌症患者的转移风险的方法和试剂盒，用于分析CpG岛甲基化表型的分析。

公开(公告)号：US20120091451A1

公开(公告)日：2012-04-19

申请号：US13264225

申请日：2010-04-14

申请人： John Vedamuthu Kennedy ,  Richard John Futter ,  Fang Fang ,  Andreas Markwitz

发明人： John Vedamuthu Kennedy ,  Richard John Futter ,  Fang Fang ,  Andreas Markwitz

IPC分类号： H01L29/12 ,  B05D5/12 ,  H05H1/48 ,  C23C16/513 ,  B82Y40/00 ,  B82Y15/00

CPC分类号： C01G9/03 ,  B82Y30/00 ,  C01P2002/54 ,  C01P2002/72 ,  C01P2002/76 ,  C01P2004/03 ,  C01P2004/16 ,  C01P2004/54 ,  C01P2006/40 ,  C01P2006/60 ,  C04B35/453 ,  C04B35/62231 ,  C04B35/6268 ,  C04B2235/3279 ,  C04B2235/3284 ,  C04B2235/526 ,  C04B2235/5264 ,  G01N33/0027

摘要： A method for preparing zinc oxide nanostructures using arc discharge is disclosed. The method comprises the provision of an anode and a cathode in an arc discharge chamber. Current is supplied to the anode and the cathode to establish an arc discharge between the cathode and the anode to vaporise the anode and produce zinc oxide nanostructures. Contemplated is the use of the zinc oxide nanostructures to produce components that have applications in, for example, optoelectronics, energy storage devices, field emission devices, and sensors such as UV photosensors, gas sensors and humidity sensors. Disclosed is a gas sensor and method for its production, where said method comprises the provision of a sensor substrate comprising a conducting thin film at least partially covering at least two regions on at least one surface of a sensor substrate material to define a gap in the conducting thin film, the application of a mixture of zinc oxide nanostructures and a non-ionic polymer to at least a portion of the gap i the conducting thin film to thereby bridge the gap. Optionally contemplated is a step of annealing the mixture of zinc oxide nanostructures and non-ionic polymer applied to said sensor substrate to produce the sensor component.

摘要翻译： 公开了一种使用电弧放电制备氧化锌纳米结构的方法。 该方法包括在电弧放电室中提供阳极和阴极。 电流被提供给阳极和阴极，以在阴极和阳极之间建立电弧放电，以蒸发阳极并产生氧化锌纳米结构。 考虑使用氧化锌纳米结构来生产在例如光电子学，能量存储器件，场致发射器件以及诸如UV光电传感器，气体传感器和湿度传感器的传感器中应用的部件。 公开了一种用于其生产的气体传感器和方法，其中所述方法包括提供传感器基底，其包括导电薄膜，至少部分地覆盖传感器基底材料的至少一个表面上的至少两个区域，以在 导电薄膜，将氧化锌纳米结构和非离子聚合物的混合物施加到导电薄膜的间隙i的至少一部分，从而桥接间隙。 可以预期的是退火施加到所述传感器基底上的氧化锌纳米结构和非离子聚合物的混合物以产生传感器部件的步骤。

公开(公告)号：US20120014404A1

公开(公告)日：2012-01-19

申请号：US12838104

申请日：2010-07-16

申请人： Guoxing Yang ,  David G. Anderson ,  Larry M. Youngblood ,  Fang Fang ,  Sean E. Rick ,  Larry A. Spino ,  Scott K. Berkhous

发明人： Guoxing Yang ,  David G. Anderson ,  Larry M. Youngblood ,  Fang Fang ,  Sean E. Rick ,  Larry A. Spino ,  Scott K. Berkhous

IPC分类号： G01N33/22 ,  G01N25/00

CPC分类号： G01N33/2805

摘要： A thermal oxidation tester is shown for determining thermal stability of a fluid, particularly hydrocarbons when subjected to elevated temperatures. The tendency of the heated fluid to oxidize and (1) form deposits on a surface of a heater tube and (2) form solids therein, are both measured at a given flow rate, temperature and time. The measured results are used to determine whether a fluid sample passes or fails the test. Results of measurements are recorded in a memory device on one end of the heater tube on which the deposits were made.

摘要翻译： 示出了热氧化测试仪，用于确定流体，特别是当受到升高的温度时的烃的热稳定性。 加热的流体氧化的趋势和（1）在加热器管的表面上形成沉积物，和（2）在其中形成固体，都在给定的流速，温度和时间下测量。 测量结果用于确定流体样品是否通过或未通过测试。 测量结果记录在其上形成沉积物的加热器管的一端上的存储器件中。

公开(公告)号：US20080299121A1

公开(公告)日：2008-12-04

申请号：US11710027

申请日：2007-02-23

申请人： Fang Fang

发明人： Fang Fang

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P31/00

CPC分类号： C07K16/2821 ,  A61K38/00 ,  C07K16/28 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/00

摘要： The present invention relates to high affinity multivalent recombinant antibodies and multivalent peptides against ICAM-1 and/or LDL receptor and pharmaceutical compositions containing such multivalent antibodies or multivalent peptides. The present invention also relates to methods of using such multivalent antibodies or multivalent peptides to prevent and treat human rhinovirus infection and diseases and pathological conditions associated therewith.

摘要翻译： 本发明涉及高亲和力多价重组抗体和针对ICAM-1和/或LDL受体的多价肽和含有这种多价抗体或多价肽的药物组合物。 本发明还涉及使用这种多价抗体或多价肽来预防和治疗人鼻病毒感染以及与之相关的疾病和病理状况的方法。