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公开(公告)号:US4415737A
公开(公告)日:1983-11-15
申请号:US451349
申请日:1982-12-20
IPC分类号: C07D277/04 , G03C8/10
CPC分类号: G03C8/10 , C07D277/04
摘要: This invention is concerned with certain 3-(thiazolidin-2'-yl)-substituted phenyl sulfonamides which find utility as intermediates in the preparation of photographic image dye-providing materials.
摘要翻译: 本发明涉及某些3-(噻唑烷-2'-基) - 取代的苯基磺酰胺,其可用作制备摄影图像染料提供材料的中间体。
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公开(公告)号:US09090541B2
公开(公告)日:2015-07-28
申请号:US13547870
申请日:2012-07-12
申请人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
发明人: Peter Viski , Beena Bhatia , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , A61K31/64 , A61K31/695 , C07D213/56 , C07C237/26 , C07C275/30 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07D295/155 , C07F9/40
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号:US08268999B2
公开(公告)日:2012-09-18
申请号:US13216606
申请日:2011-08-24
申请人: Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
发明人: Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
IPC分类号: C07D401/10 , A61K31/497
CPC分类号: C07D417/14 , C07D417/04 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作PI3K抑制剂,特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US06818635B2
公开(公告)日:2004-11-16
申请号:US09895812
申请日:2001-06-29
IPC分类号: A61K3165
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
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公开(公告)号:US6076805A
公开(公告)日:2000-06-20
申请号:US382322
申请日:1999-08-24
申请人: David Messersmith
发明人: David Messersmith
CPC分类号: B66D3/14
摘要: A rope pulling device includes a come-along (20) having a frame (30) on which are mounted an anchor end grip assembly (200) and a load end grip assembly (300). During operation, the anchor end grip assembly is locked on the rope. A hook (100) is carried on the spindle (62) of the ratchet assembly (60). A lever assembly (50) drives a pawl assembly (80) which rotates the ratchet assembly in the forward direction. The hook causes rope to move through the unlocked load end grip assembly and to wind about the spindle. When the spindle is full, the load end grip assembly is locked. A lock assembly (70), which prevents counter-rotation of the spindle is released, allowing the spindle to be reversed and emptied. Slack rope is then passed around the hook, and wound about the spindle for approximately two turns. The load end grip assembly may then be released and the spindle may again be filled with rope, thereby pulling the load (400) closer to the anchor (500).
摘要翻译: 绳索牵引装置包括具有框架(30)的落地(20),安装有锚固端部夹持组件(200)和负载端部夹持组件(300)。 在操作期间,锚固端部把手组件被锁定在绳索上。 钩子(100)被承载在棘轮组件(60)的主轴(62)上。 杠杆组件(50)驱动棘爪组件(80),棘爪组件(80)使棘轮组件沿向前方向旋转。 钩子使绳索移动通过解锁的装载端部把手组件并围绕主轴卷绕。 当主轴已满时,装载端把手组件被锁定。 释放防止主轴反向旋转的锁组件(70),从而允许主轴反向和倒空。 然后将松紧绳绕过钩子,围绕主轴缠绕大约两圈。 然后可以释放负载端部夹持组件,并且主轴可以再次用绳索填充,从而将负载(400)拉近更靠近锚固件(500)。
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公开(公告)号:US5319143A
公开(公告)日:1994-06-07
申请号:US923859
申请日:1992-07-31
申请人: David Messersmith , David P. Waller
发明人: David Messersmith , David P. Waller
IPC分类号: C07C323/25 , C07C323/24
CPC分类号: C07C323/25
摘要: There are disclosed certain bis(aminoethanethiols) and the salts thereof which find utility as intermediates in the preparation of certain dye-providing compounds useful in photographic imaging systems.
摘要翻译: 公开了某些二(氨基乙硫醇)及其盐可用作制备用于照相成像系统的某些提供染料的化合物的中间体。
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