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公开(公告)号：US09452199B2
公开(公告)日：2016-09-27
申请号：US14157819
申请日：2014-01-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
CPC classification number: A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
Abstract translation: 公开了用于释放生长因子的方法和系统。 在某些实施方案中，将血液样品暴露于一个或多个电脉冲的序列以触发样品中生长因子的释放。 在某些实施方案中，生长因子释放不伴随血液样品内的凝血。
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公开(公告)号：US09238808B2
公开(公告)日：2016-01-19
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电位的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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公开(公告)号：US20150063546A1
公开(公告)日：2015-03-05
申请号：US14202520
申请日：2014-03-10
Applicant: General Electric Company
Inventor： Antonio Caiafa , Uwe Wiedmann , Philippe Ernest , Georges William Baptiste , Dominique Poincloux , Yan Jiang
Abstract: Apparatus and methods to control an electron beam of an x-ray tube are provided. One apparatus includes at least one of (i) a first switching unit having a voltage source and a pair of switches connected in series and configured to switch between open and closed positions to change an output voltage to engage or bypass the voltage source or (ii) a second switching unit connected to a voltage source and having a first pair of switches connected in series and a second pair of switches connected in series, wherein the first and second pair of switches are connected in parallel, and wherein the first and second pairs of switches are configured to switch between open and closed position to change an output voltage generated from the voltage source. The first and second switching units are connected in series and a third switching unit provided that is amplitude controllable.
Abstract translation: 提供了用于控制X射线管的电子束的装置和方法。 一个装置包括以下至少一个：（i）第一开关单元，其具有电压源和串联连接的一对开关，并且被配置为在打开和关闭位置之间切换以改变输出电压以接合或旁路电压源，或者（ii ）连接到电压源并具有串联连接的第一对开关和串联连接的第二对开关的第二开关单元，其中所述第一和第二对开关并联连接，并且其中所述第一和第二对 的开关被配置为在打开和关闭位置之间切换以改变从电压源产生的输出电压。 第一开关单元和第二开关单元串联连接，第三开关单元设置为可调幅度。
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公开(公告)号：US20140363881A1
公开(公告)日：2014-12-11
申请号：US13911987
申请日：2013-06-06
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Andrew Soliz Torres , Allen Lawrence Garner
CPC classification number: C12N13/00 , H02J7/0052 , H02J2007/0059 , H03K3/57 , Y10T307/707
Abstract: A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.
Abstract translation: 用于在负载上施加电脉冲的脉冲发生系统包括串联连接在正极链上并被配置为向负载施加正电势的第一多个能量存储模块和串联连接在负极上的第二多个能量存储模块 并配置为向负载施加负电位。 正链和负链的每个储能模块包括整流器和存储元件，以及至少一个控制元件。
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公开(公告)号：US11525768B2
公开(公告)日：2022-12-13
申请号：US16538616
申请日：2019-08-12
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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Patent Agency Ranking
公开(公告)号：US11464829B2
公开(公告)日：2022-10-11
申请号：US16514662
申请日：2019-07-17
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC: A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US11095246B1
公开(公告)日：2021-08-17
申请号：US16789640
申请日：2020-02-13
Applicant: General Electric Company
Inventor： Antonio Caiafa , Di Pan
IPC: H02P29/028 , H02P29/50 , H02P27/08 , H02P25/22
Abstract: A system may be provided that may include an integrated motor drive configured to couple to a motor. The integrated motor drive may include a first converter that may be configured to electrically couple with a winding assembly of the motor. The first converter may include at least first conversion circuitry configured to form a first electrical excitation waveform and second conversion circuitry coupled in parallel to the second conversion circuitry and configured to form a second electrical excitation waveform. The first converter may also include a first transformer configured to form a first summation electrical excitation waveform from the first electrical excitation waveform and the second electrical excitation waveform that drives the motor.
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公开(公告)号：US20210236858A1
公开(公告)日：2021-08-05
申请号：US16781823
申请日：2020-02-04
Applicant: General Electric Company
Inventor： Lowell Scott Smith , Luca Marinelli , Larry Y.L. Mo , Antonio Caiafa , David Shoudy
Abstract: In accordance with the present disclosure, ultrasound-based techniques using a combined scanning and treatment array module are employed to find and treat anomalies corresponding to bleed events. By way of example, ultrasound data may be acquired with a scanning array at one or more locations on a patient anatomy. A treatment array may deliver heat to a targeted anomaly to provide therapy. Such a technique may be useful outside of a hospital environment.
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公开(公告)号：US10927345B2
公开(公告)日：2021-02-23
申请号：US15694635
申请日：2017-09-01
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
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公开(公告)号：US10129973B2
公开(公告)日：2018-11-13
申请号：US15186182
申请日：2016-06-17
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Antonio Caiafa
Abstract: A voltage divider circuit assembly includes resistors, an external electrostatic shield, and internal electrostatic shield(s). The resistors are in series with each other between input terminals that receive an input voltage. An external resistor is disposed between sensing terminals that conduct an output voltage that is the input voltage divided by the resistors in the series. The external shield is conductively coupled with the series of the resistors with the external resistor disposed outside of the external shield and the other resistor(s) inside the external shield. The internal shield(s) are conductively coupled with the resistors and disposed inside the external shield. A first internal resistor is disposed inside the external shield and outside of the internal shield(s). One or more remaining resistors are inside the internal shield(s). The shields divide parasitic capacitances to enable the measurement of dynamically changing high voltage input signals.
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