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公开(公告)号：US20160367632A1
公开(公告)日：2016-12-22
申请号：US15251990
申请日：2016-08-30
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , G01N33/49 , G01N33/487 , C12N13/00
CPC分类号： A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10421956B2
公开(公告)日：2019-09-24
申请号：US15955377
申请日：2018-04-17
摘要： In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US10369200B2
公开(公告)日：2019-08-06
申请号：US15252032
申请日：2016-08-30
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10329551B2
公开(公告)日：2019-06-25
申请号：US15651900
申请日：2017-07-17
摘要： In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US20170314009A1
公开(公告)日：2017-11-02
申请号：US15651900
申请日：2017-07-17
CPC分类号： C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
摘要： In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US12042526B2
公开(公告)日：2024-07-23
申请号：US17936162
申请日：2022-09-28
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , A61K35/19 , C12N13/00 , G01N33/487 , G01N33/49
CPC分类号： A61K38/1858 , A61K35/19 , C12N13/00 , G01N33/48707 , G01N33/49
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US20230013598A1
公开(公告)日：2023-01-19
申请号：US17936162
申请日：2022-09-28
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Duh-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , A61K35/19 , G01N33/49 , C12N13/00 , G01N33/487
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10383915B2
公开(公告)日：2019-08-20
申请号：US15251990
申请日：2016-08-30
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US09078862B2
公开(公告)日：2015-07-14
申请号：US13912050
申请日：2013-06-06
发明人： Vasile Bogdan Neculaes , Antonio Caiafa , Brian Duh-Lan Lee , Nicole Evelyn LaPlante , Andrew Soliz Torres , Allen Lawrence Garner
CPC分类号： A61K35/19 , A61K41/00 , A61N1/00 , C12N5/0644 , C12N13/00
摘要： Embodiments of the disclosure relate to platelet activation and/or aggregation using electric pulses. In one embodiment, a platelet-containing sample is exposed to electric pulses. At least one of the electric pulses has a duration greater than 1 microsecond and a field strength below 50 kV/cm. In another embodiment, the electric pulses may be designed with particular field strengths and durations.
摘要翻译： 本公开的实施方案涉及使用电脉冲的血小板活化和/或聚集。 在一个实施方案中，将含血小板的样品暴露于电脉冲。 电脉冲中的至少一个具有大于1微秒的持续时间和低于50kV / cm的场强。 在另一个实施例中，电脉冲可以被设计为具有特定的场强和持续时间。
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公开(公告)号：US20190336578A1
公开(公告)日：2019-11-07
申请号：US16514662
申请日：2019-07-17
发明人： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
IPC分类号： A61K38/18 , C12N13/00 , A61K35/19 , G01N33/49 , G01N33/487
摘要： Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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