Identification - friend or foe system and method
    42.
    发明授权
    Identification - friend or foe system and method 失效
    识别 - 朋友或敌人系统和方法

    公开(公告)号:US3949397A

    公开(公告)日:1976-04-06

    申请号:US516822

    申请日:1974-10-21

    摘要: Identification -- friend or foe systems which utilize computer control continuously changing interrogation signals and responding signals have been developed. The signals are varied in a time dependent manner, however, it is possible that an intruder might intercept a proper responding signal and repeat the code of this responding signal, and thus confuse the interrogating station. The present system allows a responding signal to be used only once during a particular time interval so that an interrogating station will know that if an otherwise proper responding signal is received twice during a time interval, that the second signal is spurious.

    摘要翻译: 识别 - 利用计算机控制连续改变询问信号和响应信号的朋友或敌方系统已经开发出来。 信号以时间依赖的方式变化,然而,入侵者可能拦截适当的响应信号并重复该响应信号的代码,从而使询问站混淆。 本系统允许响应信号在特定时间间隔内仅使用一次,使得询问站将知道如果在时间间隔期间接收到两次适当的响应信号,则第二信号是假的。

    Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
    47.
    发明申请
    Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof 审中-公开
    磷脂酰肌醇-3,4,5-三磷酸(PIP3)的小分子拮抗剂及其用途

    公开(公告)号:US20120136033A1

    公开(公告)日:2012-05-31

    申请号:US13321293

    申请日:2010-05-17

    摘要: Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

    摘要翻译: 公开了一类新的非脂质小分子抑制剂,其干扰PIP3和pleckstrin同源性结构域之间的相互作用。 这些分子在体外靶向广泛的PIP3依赖性信号传导事件,并在体内发挥显着的抗肿瘤活性。 本发明的小分子抑制剂可以单独使用或与肿瘤坏死因子(TNF)相关的凋亡诱导配体(TRAIL)或其他癌症药物一起用于治疗癌症。 本发明的小分子抑制剂与TRAIL联合作用协同治疗癌症。 提供了治疗癌症的药物组合物和方法。