Compositions and methods for prion decontamination
    42.
    发明申请
    Compositions and methods for prion decontamination 有权
    朊蛋白去污的组成和方法

    公开(公告)号:US20080206843A1

    公开(公告)日:2008-08-28

    申请号:US11977844

    申请日:2007-10-26

    IPC分类号: C11D7/42

    摘要: The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a prion contaminated entity with a prion-degrading composition comprising an effective amount of an oxidizing agent, an effective amount of at least one protease, and an effective amount of a surfactant. The components of the composition may be contacted with a prion-contaminated entity sequentially or simultaneously using an aqueous composition. Typically at least two different proteases are used for optimal efficacy. Preferably the oxidizing agent comprises peracetyl ions or a source thereof. The invention also relates to kits comprising the various reagents.

    摘要翻译: 本发明涉及朊病毒降解,去污或消毒的组合物和方法。 组合物包含氧化剂,一种或多种蛋白酶和表面活性剂如离子表面活性剂/洗涤剂。 该方法包括使朊病毒污染的实体与包含有效量的氧化剂,有效量的至少一种蛋白酶和有效量的表面活性剂的朊病毒降解组合物接触。 组合物的组分可以使用水性组合物依次或同时与朊病毒污染的实体接触。 通常使用至少两种不同的蛋白酶来获得最佳疗效。 优选地,氧化剂包括全乙酰离子或其源。 本发明还涉及包含各种试剂的试剂盒。