摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
摘要:
There are provided a main master station for transmitting control data by setting, as a synchronization slot, a specific transmission slot of a time division multiple access communication frame, a sub master station for transmitting the control data by setting, as a broadcast slot, a slot which does not overlap with the synchronization slot in synchronization with the main master station, and a slave station capable of communicating with the main master station and the sub master station, and the slave station waits for the control data transmitted from the sub master station in a time width decided based on a time position of the synchronization slot upon receipt of the control data from the main master station, and carries out an incoming call operation while continuously receiving the control data from either the main master station or the sub master station in an incoming call received from the other.
摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a group represented by the general formula: (wherein P represents a hydrogen atom or a group forming a prodrug), while the other represents a lower alkyl group or a halo(lower alkyl) group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo (lower alkyl) group or a halogen atom; and with the proviso that P does not represent a hydrogen atom when R represents a hydrogen atom or a lower alkyl group, or pharmaceutically acceptable salts thereof, which exert an inhibitory activity in human SGLT2 and have an improved oral absorption, and therefore are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutically acceptable salts thereof, and pharmaceutical uses thereof.
摘要翻译:本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物:其中R表示氢原子,低级烷基或形成前药的基团; Q和T之一表示由通式表示的基团:(其中P表示氢原子或形成前药的基团),而另一个表示低级烷基或卤代(低级烷基)基团; R 2表示氢原子,低级烷基,低级烷氧基,低级烷硫基,卤代(低级烷基)或卤素原子; 并且条件是当R表示氢原子或低级烷基时,P不表示氢原子,或其药学上可接受的盐,其在人SGLT2中具有抑制活性并具有改善的口服吸收,因此可用作 用于预防或治疗与高血糖相关的疾病如糖尿病,糖尿病并发症或肥胖症的药剂及其药学上可接受的盐及其药学用途。
摘要:
The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1 represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; and R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom, or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of diabetes, diabetic complications or obesity, and to pharmaceutical compositions comprising the same and intermediates thereof.
摘要:
A message processing apparatus which handles messages exchanged over a network and explicitly notifies the recipient of the importance and other information regarding each received message. Incoming messages are received by a receiver employed in the apparatus. Those messages may contain some key information as part of their attribute data, which specifies a handler program relevant to them. A key information extraction unit extracts the key information from each received message. Consulting a table that defines the relationships between handler programs and various key information, a program loading unit then loads a specific handler program relevant to the extracted key information. The recipient may cause an event related to the received message. Depending on what kind of event it is, an execution unit chooses and executes an appropriate primitive process provided as part of the handler program. When, for example, the recipient attempts to delete an unopened message, the apparatus will warn him/her by displaying a warning message on a monitor screen.
摘要:
The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1 represents a group represented by the general formula: while the other represents a lower alkyl group or a halo(lower alkyl) group; and R2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halo(lower alkyl) group or a halogen atom, or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of diabetes, diabetic complications or obesity, and to pharmaceutical compositions comprising the same and intermediates thereof.
摘要:
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom, a hydroxy group, a substituted or unsubstituted amino group, a carbamoyl group, a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group etc.; R2 represents a hydrogen atom or a lower alkyl group; and R3 represents a substituted or unsubstituted(lower alkyl) group, a substituted or unsubstituted(lower alkoxy) group, a substituted or unsubstituted(lower alkylthio) group etc., or pharmaceutically acceptable salts thereof, which have an inhibitory activity in human SGLT2 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complication or obesity, pharmaceutical compositions comprising the same and intermediates thereof.
摘要翻译:本发明涉及由以下通式表示的吡喃葡萄糖氧基苄基苯衍生物:其中R 1表示氢原子,羟基,取代或未取代的氨基,氨基甲酰基,取代或未取代的(低级烷基 )基团,取代或未取代的(低级烷氧基)基团等; R 2表示氢原子或低级烷基; 和R 3表示取代或未取代的(低级烷基)基团,取代或未取代的(低级烷氧基)基团,取代或未取代的(低级烷硫基)等,或其药学上可接受的盐,其中 在人SGLT2中具有抑制活性,并且可用作预防或治疗与高血糖相关的疾病如糖尿病,糖尿病并发症或肥胖症的药剂,包含其的药物组合物及其中间体。
摘要:
A problem solving operation apparatus obtains an optimum solution for a given problem through a combined use of a plurality of optimum solution search techniques of a genetic algorithm, and other search techniques like a hill climbing method. A combination of the optimum solution search techniques applied to each of a group of solution candidates varies according to each state. When a search efficiency in a single state is lowered, the problem solving operation apparatus immediately causes a state transition to the next state, thus enabling a search of an optimum solution through the use of another combination of more efficient optimum solution search techniques. Because a state transition constantly maintains a high search efficiency, this problem solving operation apparatus can reach an optimum solution in a short amount of time.
摘要:
A resin composition for producing a film is provided. The composition comprises (A) a high-density polyethylene having predetermined melt flow rate, density and melt tension, (B) a propylene-based polymer having predetermined melt flow rate, (C) talc, (D) CaO and/or MgO, and (E) a surface active agent. The resin compositions is readily formable into a film having excellent strength and water resistance as well as paper-like texture and rigidity. A method for producing a film by blown-film extrusion from such a resin composition is also provided. In this method, both ratio of diameter of the resulting bubble to minimum diameter of the bubble and ratio of length in machine direction of the bubble with predetermined diameter to the die diameter are adjusted to fall within predetermined ranges.
摘要:
A coating solution for forming a silica-based film, having a given viscosity, is coated on a substrate such as a silicon wafer, this coating solution is dried to form a silica-based film, and this silica-based film is exposed to ultraviolet radiation in an atmosphere containing ozone at room temperature or while heating it preferably at a temperature of not more than 300.degree. C., particularly at a temperature of from 50.degree. to 200.degree. C., by means of a heating member such as a hot plate.The film quality of the silica-based film can be improved by exposing it to ultraviolet radiation in the atmosphere containing ozone.