公开(公告)号：US08940298B2

公开(公告)日：2015-01-27

申请号：US12676348

申请日：2008-09-04

Applicant: Anna M. Wu ,  Robert E. Reiter ,  Eric J. Lepin ,  James D. Marks ,  Yu Zhou

Inventor： Anna M. Wu ,  Robert E. Reiter ,  Eric J. Lepin ,  James D. Marks ,  Yu Zhou

IPC: A61K39/395 ,  C07K16/30

CPC classification number: C07K16/3069 ,  A61K39/39558 ,  A61K51/1096 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492

Abstract: The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis, prognosis, treatment, visualization, and the like. The present invention also provides methods for the detection, visualization, and treatment of various cancers expressing PSCA.

Abstract translation: 本发明提供结合癌抗原PSCA的新型高亲和力抗体及其片段。 本发明的抗体可用于癌症诊断，预后，治疗，可视化等。 本发明还提供了用于检测，可视化和治疗表达PSCA的各种癌症的方法。

公开(公告)号：US08598321B2

公开(公告)日：2013-12-03

申请号：US12528601

申请日：2008-03-21

Applicant: James D. Marks ,  Isin N. Geren ,  Jianlong Lou

Inventor： James D. Marks ,  Isin N. Geren ,  Jianlong Lou

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/385 ,  A61K39/40 ,  A61K39/42 ,  A01N37/18 ,  C07K16/00 ,  C12P21/08 ,  G01N33/00

CPC classification number: C07K16/40 ,  C07K16/1282 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

公开(公告)号：US20110218333A1

公开(公告)日：2011-09-08

申请号：US12928792

申请日：2010-12-16

Applicant: James D. Marks ,  Marie Alix Poul

Inventor： James D. Marks ,  Marie Alix Poul

IPC: C07H21/04

CPC classification number: A61K47/48823 ,  A61K9/0019 ,  A61K31/704 ,  A61K38/00 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6865 ,  A61K47/6913 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/10 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10043 ,  C12N2810/859 ,  Y10S424/812

Abstract: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.

Abstract translation: 本发明提供新的erbB2结合内化抗体。 称为F5和C1的抗体特异性结合c-erbB2抗原，并且在结合时容易内化到带有c-erbB2标记的细胞中。 还提供了包含与一个或多个效应分子相连的F5和/或C1抗体的嵌合分子。

公开(公告)号：US20110200615A1

公开(公告)日：2011-08-18

申请号：US13055436

申请日：2009-07-30

Applicant: James D. Marks ,  Jianlong Lou ,  Maria Consuelos Garcia Rodriguez ,  Isin N. Geren

Inventor： James D. Marks ,  Jianlong Lou ,  Maria Consuelos Garcia Rodriguez ,  Isin N. Geren

IPC: A61K39/40 ,  C07K16/12 ,  C07H21/04 ,  C12N1/19 ,  A61P31/04 ,  A61P39/02

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: This disclosure provides antibodies that specifically bind to and typically neutralize botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/E, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本公开提供了特异性结合并通常中和肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / E等）和由那些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US20110171235A1

公开(公告)日：2011-07-14

申请号：US12646705

申请日：2009-12-23

Applicant: James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelo Garcia

Inventor： James D. Marks ,  Peter Amersdorfer ,  Isin Geren ,  Jianlong Lou ,  Ali Razai ,  Maria Consuelo Garcia

IPC: A61K39/40 ,  C07K16/12 ,  A61P39/00

CPC classification number: C07K16/1282 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US20100196265A1

公开(公告)日：2010-08-05

申请号：US12515522

申请日：2007-11-20

Applicant: Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

Inventor： Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

IPC: A61K51/10 ,  C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  A61K39/44 ,  A61K9/127 ,  A61K51/12 ,  C07H21/04 ,  A61P35/00 ,  C12N15/74 ,  C12N5/10

CPC classification number: C07K16/2863 ,  A61K47/6849 ,  A61K47/6879 ,  A61K49/0017 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/74 ,  G01N2333/485

Abstract: Anti-EGFR family member antibodies and bispecific antibodies comprising one or more anti-EGFR family member antibodies are disclosed. These antibodies can be used to advantage to specifically target forms of cancer associated with the overexpression of members of the EGFR protein family.

Abstract translation: 公开了抗EGFR家族成员抗体和包含一种或多种抗EGFR家族成员抗体的双特异性抗体。 这些抗体可以用于特异性靶向与EGFR蛋白家族的成员的过表达相关的癌症形式。

公开(公告)号：US07563874B2

公开(公告)日：2009-07-21

申请号：US10632706

申请日：2003-08-01

Applicant: James D. Marks ,  Peter Amersdorfer

Inventor： James D. Marks ,  Peter Amersdorfer

IPC: A61K38/00 ,  A61K38/16 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A01N37/18 ,  C07K16/00 ,  C12P21/08

CPC classification number: C07K16/1282 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622

Abstract: This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本发明提供了特异性结合并中和A型（BoNT / A）肉毒杆菌神经毒素和由这些抗体结合的表位的抗体。 特异性结合本文提供的中和表位的抗体及其衍生物和/或其他抗体可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。

公开(公告)号：US20090105086A1

公开(公告)日：2009-04-23

申请号：US12154688

申请日：2008-05-23

Applicant: James D. Marks ,  Marie Alix Poul ,  Baltazar Becerril

Inventor： James D. Marks ,  Marie Alix Poul ,  Baltazar Becerril

IPC: C40B30/04

CPC classification number: C12N15/1037 ,  A61K38/00 ,  A61K47/6843 ,  C07K14/005 ,  C07K16/2863 ,  C07K16/2881 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2319/02 ,  C12N15/86 ,  C12N2795/10022

Abstract: This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage display library. The members of the phage display library are also contacted with cells of a subtractive cell line. The target cells are then washed to remove the subtractive cell line cells and members of the phage display library that are non-specifically bound or weakly bound to the target cells. The target cells are cultured under conditions where members of the phage display library can be internalized if bound to an internalizing marker and internalized members of the phage display library are then identified.

Abstract translation: 本发明提供了选择内化于靶细胞中的抗体的方法。 所述方法通常涉及使靶细胞与抗体噬菌体展示文库的一个或多个成员接触。 噬菌体展示文库的成员也与减数细胞系的细胞接触。 然后洗涤靶细胞以除去非特异性结合或弱结合到靶细胞的消减细胞系细胞和噬菌体展示文库的成员。 靶细胞在噬菌体展示文库的成员可以内化的条件下培养，如果结合到内化标记物，然后鉴定噬菌体展示文库的内化成员。

公开(公告)号：US07388088B2

公开(公告)日：2008-06-17

申请号：US10092640

申请日：2002-03-05

Applicant: James D. Marks ,  Robert Schier

Inventor： James D. Marks ,  Robert Schier

IPC: C07H21/04

CPC classification number: C07K16/32 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  F16H59/105 ,  F16H61/32 ,  F16H2061/326 ,  G01N33/57492 ,  G01N2333/71

Abstract: This invention provides for novel human antibodies that specifically bind to c-erbB-2. The antibodies may be used alone or as components of chimeric molecules that specifically target and deliver effector molecules to cells overexpressing c-erbB-2.

Abstract translation: 本发明提供特异性结合c-erbB-2的新型人抗体。 抗体可以单独使用或作为特异性靶向并将效应分子递送至过量表达c-erbB-2的细胞的嵌合分子的组分使用。

公开(公告)号：US07332580B2

公开(公告)日：2008-02-19

申请号：US10406830

申请日：2003-04-04

Applicant: Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

Inventor： Gregory P. Adams ,  Eva M. Horak ,  Louis M. Weiner ,  James D. Marks

IPC: C07K16/00

CPC classification number: C07K16/32 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/622

Abstract: Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family.

Abstract translation: 公开了双特异性单链抗体分子，其可用于治疗与EGFR蛋白家族的成员的过表达相关的各种形式的癌症。