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    Methods and apparatus for point-of-care nucleic acid amplification and detection
    41.
    发明授权
    Methods and apparatus for point-of-care nucleic acid amplification and detection 有权
    点对点核酸扩增和检测的方法和装置

    公开(公告)号：US08911941B2

    公开(公告)日：2014-12-16

    申请号：US13447218

    申请日：2012-04-14

    申请人： Kenneth J. Michlitsch

    发明人： Kenneth J. Michlitsch

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/36

    CPC分类号： C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607

    摘要： Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. Optionally, sample preparation is fully or partially achieved via heat treatment and/or using a filter paper, such as a chemically treated filter paper, e.g., an FTA card. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction.

    摘要翻译： 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 任选地，样品制备通过热处理和/或使用滤纸例如化学处理的滤纸例如FTA卡完全或部分实现。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测添加到扩增反应中的染料中的色移或荧光来实现。

    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION
    42.
    发明申请
    METHODS AND APPARATUS FOR POINT-OF-CARE NUCLEIC ACID AMPLIFICATION AND DETECTION 有权
    点保护核酸放大和检测的方法和装置

    公开(公告)号：US20140356874A1

    公开(公告)日：2014-12-04

    申请号：US14262683

    申请日：2014-04-25

    申请人： Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    发明人： Jane P. Bearinger ,  Scott Castanon ,  Kenneth J. Michlitsch

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6844 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/00 ,  B01L2300/0861 ,  B01L2300/18 ,  B01L2400/06 ,  C12Q1/6825 ,  C12Q1/6846 ,  C12Q2547/101 ,  C12Q2563/173 ,  C12Q2565/607 ,  C12Q2527/101 ,  C12Q2563/107 ,  C12Q2565/629

    摘要： Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

    摘要翻译： 提供了用于点对点核酸扩增和检测的方法和装置。 本发明的一个实施方案包括完全整合的样品至答复分子诊断仪器，其可任选地以多路复用方式使用以检测目标的多个靶核酸序列，并且可任选地配置为在一次使用后进行处置。 该仪器优选使用等温核酸扩增技术，例如环介导的等温扩增（LAMP），以减少与核酸扩增相关的仪器要求。 靶扩增的检测可以例如通过检测加入到扩增反应中的染料中的色移或荧光来实现。 这种检测可以由操作者视觉执行，或者可以使用成像技术（例如分光光度成像）来实现。

    Handle assemblies for intravascular treatment devices and associated systems and methods
    43.
    发明授权
    Handle assemblies for intravascular treatment devices and associated systems and methods 有权
    手术组件用于血管内治疗装置及相关系统和方法

    公开(公告)号：US08808345B2

    公开(公告)日：2014-08-19

    申请号：US12759641

    申请日：2010-04-13

    申请人： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

    发明人： Benjamin J. Clark ,  William R. George ,  Kenneth J. Michlitsch ,  John Paul Sam ,  Erik Thai ,  Andrew Wu

    IPC分类号： A61B18/08 ,  A61B19/00 ,  A61B17/00 ,  A61B18/00

    CPC分类号： A61B18/08 ,  A61B34/74 ,  A61B2017/003 ,  A61B2018/00916

    摘要： The present disclosure comprises handle assemblies for intravascular treatment devices. In one embodiment, a handle assembly comprises an actuator for deflecting a distal region of an intravascular treatment device. In one embodiment, a handle assembly comprises a rotator for rotating an intravascular treatment device independently of the handle assembly. In one embodiment, a handle assembly comprises a rotation limiting element for limiting independent rotation of an intravascular treatment device relative to the handle assembly. Methods and systems for intravascular delivery, deflection and placement of an intravascular treatment device via a handle assembly of the present invention are also provided.

    摘要翻译： 本公开包括用于血管内治疗装置的手柄组件。 在一个实施例中，手柄组件包括用于偏转血管内治疗装置的远侧区域的致动器。 在一个实施例中，手柄组件包括用于独立于手柄组件旋转血管内治疗装置的旋转器。 在一个实施例中，手柄组件包括用于限制血管内治疗装置相对于手柄组件的独立旋转的旋转限制元件。 还提供了通过本发明的手柄组件进行血管内递送，偏转和放置血管内治疗装置的方法和系统。

    AUTOLOGOUS WOUND SEALING APPARATUS
    45.
    发明申请
    AUTOLOGOUS WOUND SEALING APPARATUS 有权
    自动封口机

    公开(公告)号：US20130006300A1

    公开(公告)日：2013-01-03

    申请号：US13615551

    申请日：2012-09-13

    申请人： Kenneth J. Michlitsch

    发明人： Kenneth J. Michlitsch

    IPC分类号： A61B17/03

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

    摘要： The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

    摘要翻译： 该装置用于通过在穿刺管内形成自体塞子并将该塞子挤压到穿刺管中来密封血管穿刺道。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件，以在与血液凝结剂混合期间将抽取的血液与血管隔离，并且便于相对于血管的装置放置。

    Everting heart valve
    48.
    发明授权
    Everting heart valve 有权
    永恒心脏瓣膜

    公开(公告)号：US07780725B2

    公开(公告)日：2010-08-24

    申请号：US10870340

    申请日：2004-06-16

    申请人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

    发明人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

    IPC分类号： A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

    摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

    摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

    Apparatus for a reusable, heated ice cream scoop containing supercoolable salt solution
    50.
    发明授权
    Apparatus for a reusable, heated ice cream scoop containing supercoolable salt solution 失效
    用于可重复使用，加热的冰淇淋勺装置，含有过冷却盐溶液

    公开(公告)号：US06416309B1

    公开(公告)日：2002-07-09

    申请号：US09505444

    申请日：2000-02-16

    申请人： Kenneth J. Michlitsch ,  Shaun Meredith ,  Daniel J. Keating ,  Yaakov Weinstein ,  Eugene Lee ,  Michael D. Rees ,  Darren Soetantyo ,  Sean Padgett ,  Steven D. Eppinger

    发明人： Kenneth J. Michlitsch ,  Shaun Meredith ,  Daniel J. Keating ,  Yaakov Weinstein ,  Eugene Lee ,  Michael D. Rees ,  Darren Soetantyo ,  Sean Padgett ,  Steven D. Eppinger

    IPC分类号： A23G0928

    CPC分类号： A47J43/282

    摘要： Methods and apparatus are provided for serving ice cream with a chemically-heated ice cream scoop. The scoop comprises a bowl and a handle with an interior cavity filled with a nontoxic, supercoolable salt solution. The salt solution may be selectively crystallized by triggering an activator in fluid communication with the solution. Crystallization evolves a significant amount of heat that is used to elevate the temperature of the scoop bowl, thereby decreasing the cutting force required to separate a serving of ice cream from a storage container and reducing adherence of the ice cream within the scoop bowl. After use, the scoop may be recharged by elevating the temperature of the crystallized solution above its crystallization temperature. The process of crystallization, melting, and supercooling may be repeated indefinitely.

    摘要翻译： 提供了用化学加热的冰淇淋勺提供冰淇淋的方法和装置。 勺子包括碗和具有填充有无毒的过冷却盐溶液的内部空腔的手柄。 可以通过触发与溶液流体连通的活化剂来选择性地结晶盐溶液。 结晶产生大量的热量，用于提高勺子的温度，从而降低将冰淇淋从储存容器分离出来并减少勺子中冰淇淋粘附所需的切割力。 使用后，可以通过将结晶溶液的温度升高到其结晶温度以上来对勺子进行再充电。 结晶，熔化和过冷却的过程可以无限期地重复。