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公开(公告)号：US08013124B2
公开(公告)日：2011-09-06
申请号：US12193665
申请日：2008-08-18
申请人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Angela K. Hammond , Julia E. Novak
发明人： Cindy A. Sprecher , Joseph L. Kuijper , Maria M. Dasovich , Francis J. Grant , Angela K. Hammond , Julia E. Novak
IPC分类号： C07K14/52 , A61K39/395
CPC分类号： C07K16/24 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/52 , C07K2317/24
摘要： The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 本发明涉及zcytor17lig多核苷酸，多肽和抗zcytor17抗体分子。 zcytor17lig是一种新型细胞因子。 多肽可用于刺激免疫系统的方法，体外和体内造血细胞的增殖和/或发育。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07919595B2
公开(公告)日：2011-04-05
申请号：US12895139
申请日：2010-09-30
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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43.发明授权Method of using interferon-like protein ZCYTO21 (IL-29) to treat hepatitis C 有权使用干扰素样蛋白ZCYTO21（IL-29）治疗丙型肝炎的方法公开(公告)号：US07655223B2
公开(公告)日：2010-02-02
申请号：US11873272
申请日：2007-10-16
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US20090069274A1
公开(公告)日：2009-03-12
申请号：US11873272
申请日：2007-10-16
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：US07498154B2
公开(公告)日：2009-03-03
申请号：US11925097
申请日：2007-10-26
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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46.发明授权Nucleic acid encoding a human allelic variant of interferon-like protein ZCYTO21 有权编码干扰素样蛋白ZCYTO21的人等位基因变体的核酸公开(公告)号：US07445913B2
公开(公告)日：2008-11-04
申请号：US11548023
申请日：2006-10-10
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
摘要翻译： 本发明涉及用于Zcyto21的多核苷酸和多肽分子，干扰素样蛋白与氨基酸序列水平上的干扰素-α最相关。 本发明还包括对Zcyto21多肽的抗体，以及使用多核苷酸和多肽的方法。
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公开(公告)号：US07252969B2
公开(公告)日：2007-08-07
申请号：US10927891
申请日：2004-08-27
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：US06927040B2
公开(公告)日：2005-08-09
申请号：US09895834
申请日：2001-06-29
申请人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
发明人： Paul O. Sheppard , Scott R. Presnell , Brian A. Fox , Teresa Gilbert , Betty A. Haldeman , Francis J. Grant
IPC分类号： G01N33/53 , C07H21/02 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/555 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/99 , C12N15/09 , C12N15/19 , C12N15/21 , C12N15/74 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47 , C07K14/52 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
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公开(公告)号：US5919635A
公开(公告)日：1999-07-06
申请号：US452930
申请日：1995-05-30
申请人： Wayne R. Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , Francis J. Grant , Joseph L. Kuijper , Donald C. Foster , Si Lok , Patrick J. O'Hara
发明人： Wayne R. Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , Francis J. Grant , Joseph L. Kuijper , Donald C. Foster , Si Lok , Patrick J. O'Hara
IPC分类号： G01N33/566 , A61K38/00 , C07H21/04 , C07K14/605 , C07K14/72 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/66 , C12Q1/68 , G01N33/50 , G01N33/74 , C07K14/705
CPC分类号： C07K14/723 , C07K14/72 , C12Q1/66 , G01N33/74 , A61K38/00 , C07K2319/00 , C07K2319/02 , G01N2333/605 , G01N2333/72
摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides a method for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon against to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.
摘要翻译： 本发明提供了分离的DNA分子，其包含编码胰高血糖素受体的DNA区段。 还提供了DNA构建体，其包含编码与第一DNA区段表达所需的另外的DNA区段可操作地连接的胰高血糖素受体的第一DNA区段，以及含有这种DNA构建体的宿主细胞。 本发明还提供了一种用于检测胰高血糖素拮抗剂的存在的方法，其包括以下步骤：（a）在条件和时间足以允许的情况下，在与胰岛素反应途径偶联的重组胰高血糖素受体上暴露化合物 化合物与受体的结合和通过途径的相关应答，以及（b）相对于刺激响应途径，检测由化合物与胰高血糖素受体的结合引起的反应途径的刺激减少 胰高血糖素激动剂单独和由此决定胰高血糖素拮抗剂的存在。
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公开(公告)号：US5770445A
公开(公告)日：1998-06-23
申请号：US453956
申请日：1995-05-30
申请人： Wayne R. Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , Francis J. Grant , Joseph L. Kuijper , Donald C. Foster , Si Lok , Patrick J. O'Hara
发明人： Wayne R. Kindsvogel , Laura J. Jelinek , Paul O. Sheppard , Francis J. Grant , Joseph L. Kuijper , Donald C. Foster , Si Lok , Patrick J. O'Hara
IPC分类号： G01N33/566 , A61K38/00 , C07H21/04 , C07K14/605 , C07K14/72 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/66 , C12Q1/68 , G01N33/50 , G01N33/74
CPC分类号： C07K14/723 , C07K14/72 , C12Q1/66 , G01N33/74 , A61K38/00 , C07K2319/00 , C07K2319/02 , G01N2333/605 , G01N2333/72
摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a glucagon receptor. Also provided are DNA constructs comprising a first DNA segment encoding a glucagon receptor operably linked to additional DNA segments required for the expression of the first DNA segment, as well as host cells containing such DNA constructs. The present invention also provides a method for detecting the presence of glucagon antagonists, comprising the steps of (a) exposing a compound in the presence of a glucagon against to a recombinant glucagon receptor coupled to a response pathway under conditions and for time sufficient to allow binding of the compound to the receptor and an associated response through the pathway, and (b) detecting a reduction in the stimulation of the response pathway resulting from the binding of the compound to the glucagon receptor, relative to the stimulation of the response pathway by the glucagon agonist alone and therefrom determining the presence of a glucagon antagonist.
摘要翻译： 本发明提供了分离的DNA分子，其包含编码胰高血糖素受体的DNA区段。 还提供了DNA构建体，其包含编码与第一DNA区段表达所需的另外的DNA区段可操作地连接的胰高血糖素受体的第一DNA区段，以及含有这种DNA构建体的宿主细胞。 本发明还提供了一种用于检测胰高血糖素拮抗剂的存在的方法，其包括以下步骤：（a）在条件和时间足以允许的情况下，在与胰岛素反应途径偶联的重组胰高血糖素受体上暴露化合物 化合物与受体的结合和通过途径的相关应答，以及（b）相对于刺激响应途径，检测由化合物与胰高血糖素受体的结合引起的反应途径的刺激减少 胰高血糖素激动剂单独和由此决定胰高血糖素拮抗剂的存在。
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