-
公开(公告)号：US07176299B2
公开(公告)日：2007-02-13
申请号：US11166905
申请日：2005-06-23
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
-
公开(公告)号：US06465621B1
公开(公告)日：2002-10-15
申请号：US09631548
申请日：2000-08-03
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C07K1700
CPC分类号： C12N9/78 , A61K39/00 , C07K14/31 , C07K16/1275 , C12Y305/04025
摘要： The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
摘要翻译： 本发明提供了ERA多肽和编码ERA多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用ERA多肽以防止感染，特别是细菌感染的方法。
-
公开(公告)号：US06365159B1
公开(公告)日：2002-04-02
申请号：US09340475
申请日：1999-06-30
申请人： Martin Karl Russel Burnham , Daniel Robert Gentry , John Edward Hodgson , Elizabeth Jane Lawlor
发明人： Martin Karl Russel Burnham , Daniel Robert Gentry , John Edward Hodgson , Elizabeth Jane Lawlor
IPC分类号： A61K3902
CPC分类号： C07K14/31 , A61K38/00 , A61K39/00 , A61K2039/51
摘要： spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
摘要翻译： 披露了spo-rel多肽和编码这种spo-rel的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种spo-rel来治疗感染，特别是细菌感染的方法。 还公开了抗这种害虫的拮抗剂及其用作治疗感染，特别是细菌感染的治疗剂。 还公开了用于检测与宿主中spo-rel核酸序列和多肽的存在相关的疾病的诊断测定法。 还公开了用于检测编码relA / spoT基因家族的多核苷酸并用于检测宿主中的多肽的诊断测定法。
-
44.发明授权公开(公告)号：US06346392B1
公开(公告)日：2002-02-12
申请号：US08919573
申请日：1997-07-10
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Phillip N Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Martin Karl Russel Burnham , Robert H Reid, Jr. , Phillip N Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供谷氨酰胺转运ATP结合蛋白多肽和编码谷氨酰胺转运ATP结合蛋白多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用谷氨酰胺转运ATP结合蛋白多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06323336B1
公开(公告)日：2001-11-27
申请号：US09322081
申请日：1999-05-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07H2104
CPC分类号： C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要： The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同源多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06294661B1
公开(公告)日：2001-09-25
申请号：US09155920
申请日：1999-03-05
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Robert King Stodola
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Richard O Nicholas , Robert King Stodola
IPC分类号： C07H2104
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00
摘要： The invention provides RF-1 polypeptides and DNA (RNA) encoding RF-1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RF-1 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了RF-1多肽和编码RF-1多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还提供了利用RF-1多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06287803B1
公开(公告)日：2001-09-11
申请号：US08965130
申请日：1997-11-06
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Robert H. Reid , Martin Rosenberg , Phillip Zarfos
IPC分类号： C12N1531
CPC分类号： G01N33/68 , A61K38/00 , A61K39/00 , C07K14/3156 , C07K2319/00 , G01N2333/315
摘要： The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码时代多肽的时代多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用时代多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06248863B1
公开(公告)日：2001-06-19
申请号：US09343986
申请日：1999-06-29
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07K500
CPC分类号： C07K14/31 , A61K39/00 , C07K16/1275 , C12N9/78 , C12Y305/04025
摘要： The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for anitbacterial compounds.
摘要翻译： 本发明提供phoH同系物多肽和编码phoH同源多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用phoH同系物多肽来筛选脱细菌化合物的方法。
-
公开(公告)号：US06228619B1
公开(公告)日：2001-05-08
申请号：US08948265
申请日：1997-10-09
申请人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
发明人： Simon J Foster , Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard O Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward
IPC分类号： C12N1509
CPC分类号： C12Y302/01096 , A61K39/00 , A61K2039/53 , C07K14/31 , C07K16/1275 , C12N9/2402 , C12N9/78 , C12Y302/01023 , C12Y305/04025
摘要： The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了氨基葡糖苷酶多肽和编码氨基葡糖苷酶多肽的DNA（RNA），以及通过重组技术产生这种多肽的方法。 还提供了利用氨基葡糖苷酶多肽筛选抗菌化合物的方法。
-
公开(公告)号：US6071892A
公开(公告)日：2000-06-06
申请号：US844054
申请日：1997-04-18
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P31/04 , A61P37/02 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12N15/31 , G01N33/15 , C07H12/00
摘要： The invention provides tyrS polypeptides and DNA (RNA) encoding tyrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tyrS polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了tyrS多肽和编码tyrS多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用tyrS多肽筛选抗菌化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
108 条记录 (耗时 0.043 秒)
