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公开(公告)号：US06280971B1
公开(公告)日：2001-08-28
申请号：US09227806
申请日：1999-01-11
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
IPC分类号： C12N1231
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US07176299B2
公开(公告)日：2007-02-13
申请号：US11166905
申请日：2005-06-23
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号：US06171598B2
公开(公告)日：2001-01-09
申请号：US09225967
申请日：1999-01-06
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： A61K3850
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US5891672A
公开(公告)日：1999-04-06
申请号：US977554
申请日：1997-11-25
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Yi Zhong
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/43 , A61K39/085 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/00 , A61P25/00 , A61P27/02 , A61P27/16 , A61P43/00 , C07H21/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/78 , C12N9/86 , C12N15/09 , C12N15/31 , C12P21/02 , C12R1/445 , C07H21/00 , C12N15/63
CPC分类号： C12Y305/04025 , C12N9/78 , C07K2319/00
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06448036B1
公开(公告)日：2002-09-10
申请号：US08977866
申请日：1997-11-25
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： C07H2104
CPC分类号： C12N9/1085 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C12N9/78 , C12Y205/01009 , C12Y305/04025
摘要： The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribB多肽和编码ribB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribB多肽筛选抗菌化合物的方法。
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公开(公告)号：US06280735B1
公开(公告)日：2001-08-28
申请号：US09369700
申请日：1999-08-06
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： A61K3902
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号：US6010881A
公开(公告)日：2000-01-04
申请号：US978456
申请日：1997-11-25
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M Ward , Richard Lloyd Warren
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/395 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/31 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/78 , C12N15/09 , C12N15/52 , C12Q1/68 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0036 , C07K14/31 , C07K16/1275 , C12N15/52 , C12N9/78 , C12Q1/689 , C12Y105/0103 , C12Y305/04025 , A61K38/00 , A61K39/00 , C07K2319/00 , C12Q2600/158
摘要： The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribG多肽和编码ribG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribG多肽筛选抗菌化合物的方法。
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公开(公告)号：US06320036B1
公开(公告)日：2001-11-20
申请号：US09310867
申请日：1999-05-13
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： C07H2104
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了gbpA多肽和编码gbpA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用gbpA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06203800B1
公开(公告)日：2001-03-20
申请号：US09273613
申请日：1999-03-22
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： A61K39085
CPC分类号： C12N9/0006 , A61K38/00 , A61K39/00 , C07K14/31 , C07K2319/00 , C12N9/00 , C12N9/1205 , C12N9/88 , Y10S435/883
摘要： The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了gbpA多肽和编码gbpA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用gbpA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06344540B1
公开(公告)日：2002-02-05
申请号：US09363160
申请日：1999-07-28
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Michael Arthur Lonetto , Patrick Vernon Warren
IPC分类号： A61K3800
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要： The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了pai多肽和编码pai多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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